公开(公告)号：US20230320994A1

公开(公告)日：2023-10-12

申请号：US18042390

申请日：2021-08-23

Applicant: The Board of Regents of The University of Texas System

Inventor： Daniel J. SIEGWART ,  Shuai LIU ,  Xueliang YU ,  Qiang CHENG ,  Tuo WEI

IPC: A61K9/51 ,  C07F9/10 ,  A61K47/54

CPC classification number: A61K9/5123 ,  A61K47/544 ,  C07F9/106

Abstract: Ionizable phospholipids and compositions and methods relating thereof are provided herein. In some aspects, the ionizable phospholipids provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.

公开(公告)号：US20220071916A1

公开(公告)日：2022-03-10

申请号：US17191975

申请日：2021-03-04

Applicant: The Board of Regents of the University of Texas System

Inventor： Qiang CHENG ,  Tuo WEI ,  Daniel J. SIEGWART

IPC: A61K9/51 ,  A61K31/7105 ,  A61K38/46 ,  A61K31/713

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.