公开(公告)号：US20240245620A1

公开(公告)日：2024-07-25

申请号：US18590737

申请日：2024-02-28

Applicant: The Board of Regents of The University of Texas System

Inventor： Qiang CHENG ,  Tuo WEI ,  Daniel J. SIEGWART

IPC: A61K9/51 ,  A61K48/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113

CPC classification number: A61K9/5123 ,  A61K48/0033 ,  C12N9/22 ,  C12N15/11 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/20 ,  C12N2320/32

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

公开(公告)号：US20240148666A1

公开(公告)日：2024-05-09

申请号：US18534974

申请日：2023-12-11

Applicant: The Board of Regents of The University of Texas System

Inventor： Qiang CHENG ,  Tuo WEI ,  Daniel J. SIEGWART

IPC: A61K9/51 ,  A61K48/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113

CPC classification number: A61K9/5123 ,  A61K48/0033 ,  C12N9/22 ,  C12N15/11 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/20 ,  C12N2320/32

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

公开(公告)号：US20220233460A1

公开(公告)日：2022-07-28

申请号：US17711911

申请日：2022-04-01

Applicant: The Board of Regents of The University of Texas System

Inventor： Qiang CHENG ,  Tuo WEI ,  Daniel J. SIEGWART

IPC: A61K9/51 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113 ,  A61K48/00

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

公开(公告)号：US20210259980A1

公开(公告)日：2021-08-26

申请号：US17191895

申请日：2021-03-04

Applicant: The Board of Regents of the University of Texas System

Inventor： Qiang CHENG ,  Tuo WEI ,  Daniel J. SIEGWART

IPC: A61K9/51 ,  C12N9/22 ,  C12N15/11 ,  A61K48/00

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

公开(公告)号：US20240325315A1

公开(公告)日：2024-10-03

申请号：US18744370

申请日：2024-06-14

Applicant: The Board of Regents of The University of Texas System

Inventor： Daniel J. SIEGWART ,  Qiang CHENG

IPC: A61K9/51 ,  A61K48/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113

CPC classification number: A61K9/5123 ,  A61K48/0033 ,  C12N9/22 ,  C12N15/11 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/20 ,  C12N2320/32

Abstract: In some aspects, the present disclosure provides compositions of lipid nanoparticles useful for the delivery of large RNAs including mRNAs. These compositions may include a cationic ionizable lipid, a phospholipid, a PEGylated lipid, and a steroid including using less of a cationic ionizable lipid than compositions with shorter nucleic acids. These compositions may be used to treat a disease or disorder for which the delivery of an mRNA is therapeutically effective.

公开(公告)号：US20240261440A1

公开(公告)日：2024-08-08

申请号：US18419370

申请日：2024-01-22

Applicant: The Board of Regents of The University of Texas System

Inventor： Tuo WEI ,  Yehui SUN ,  Qiang CHENG ,  Daniel SIEGWART

IPC: A61K48/00 ,  A61K31/7088 ,  A61K38/46 ,  A61K47/24 ,  A61K47/54 ,  C07K14/705 ,  C12N9/22 ,  C12N15/11 ,  C12N15/88 ,  C12N15/90

CPC classification number: A61K48/0066 ,  A61K31/7088 ,  A61K38/465 ,  A61K47/24 ,  A61K47/543 ,  C07K14/705 ,  C12N9/22 ,  C12N15/11 ,  C12N15/88 ,  C12N15/907 ,  C12N2310/20 ,  C12N2800/80

Abstract: Described herein are compositions, kits, and methods for potent delivery to a cell of a subject. The cell can be of a particular cell type, such as a basal cell, a ciliated cell, or a secretory cell. In some cases, the cell can be a lung cell of a particular cell type. Also described herein are pharmaceutical compositions comprising a therapeutic or prophylactic agent assembled with a lipid composition. The lipid composition can comprise an ionizable cationic lipid, a phospholipid, and a selective organ targeting lipid. Further described herein are high-potency dosage forms of a therapeutic or prophylactic agent formulated with a lipid composition.

公开(公告)号：US20220387337A1

公开(公告)日：2022-12-08

申请号：US17839699

申请日：2022-06-14

Applicant: The Board of Regents of The University of Texas System

Inventor： Qiang CHENG ,  Tuo WEI ,  Daniel J. SIEGWART

IPC: A61K9/51 ,  A61K48/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

公开(公告)号：US20220133637A1

公开(公告)日：2022-05-05

申请号：US17572615

申请日：2022-01-10

Applicant: The Board of Regents of The University of Texas System

Inventor： Qiang CHENG ,  Tuo WEI ,  Daniel J. SIEGWART

IPC: A61K9/51 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113 ,  A61K48/00

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

公开(公告)号：US20230026843A1

公开(公告)日：2023-01-26

申请号：US17929704

申请日：2022-09-04

Applicant: The Board of Regents of The University of Texas System

Inventor： Qiang CHENG ,  Tuo WEI ,  Daniel J. SIEGWART

IPC: A61K9/51 ,  A61K48/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

公开(公告)号：US20210401762A1

公开(公告)日：2021-12-30

申请号：US17473863

申请日：2021-09-13

Applicant: The Board of Regents of the University of Texas System

Inventor： Qiang CHENG ,  Tuo WEI ,  Daniel J. SIEGWART

IPC: A61K9/51 ,  A61K48/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.