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公开(公告)号：US20190316139A1
公开(公告)日：2019-10-17
申请号：US16256933
申请日：2019-01-24
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/113 , C12N15/10 , C12N15/11 , C12N15/82 , A61K31/713
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for F12.
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公开(公告)号：US10421970B2
公开(公告)日：2019-09-24
申请号：US16378629
申请日：2019-04-09
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/113
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for COX-2.
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公开(公告)号：US09839649B2
公开(公告)日：2017-12-12
申请号：US14936395
申请日：2015-11-09
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/113 , C07H21/02 , A61K31/713 , C12N15/10 , C12N15/11 , C12N15/82
CPC分类号： A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N15/8218 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12N2320/13 , C12N2330/31 , C12Y113/12007 , C12Y502/01008
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for AAT.
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公开(公告)号：US09777270B2
公开(公告)日：2017-10-03
申请号：US14965816
申请日：2015-12-10
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C07H21/02 , C12N15/113 , A61K31/713 , C07H21/04 , C12N15/10 , C12N15/11
CPC分类号： C12N15/113 , A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12Y113/12007 , C12Y502/01008
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
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公开(公告)号：US20160369278A1
公开(公告)日：2016-12-22
申请号：US15255829
申请日：2016-09-02
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/713 , C12N2310/14
摘要： Efficient sequence specific gene silencing is possible through the use of RNAi technology. By selecting particular RNAi molecules by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of RNAi molecules are disclosed including those directed to nucleotide sequences for CNTD2.
摘要翻译： 通过使用RNAi技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的RNAi分子，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。 公开了通过RNAi分子的合理设计产生的方法，组合物和试剂盒，包括针对CNTD2的核苷酸序列的那些。
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16.发明申请公开(公告)号：US20160193242A1
公开(公告)日：2016-07-07
申请号：US14936395
申请日：2015-11-09
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： A61K31/713 , C12N15/113
CPC分类号： A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N15/8218 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12N2320/13 , C12N2330/31 , C12Y113/12007 , C12Y502/01008
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for AAT.
摘要翻译： 通过使用siRNA技术，有效的序列特异性基因沉默是可能的。 通过合理设计选择特定的siRNA，可以最大限度地发挥有效的基因沉默试剂的产生，以及沉默基因的方法。 公开了通过合理设计siRNA产生的方法组合物和试剂盒，包括针对AAT的核苷酸序列的组合物和试剂盒。
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公开(公告)号：US20190106699A1
公开(公告)日：2019-04-11
申请号：US16171166
申请日：2018-10-25
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/113
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for LDHA.
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公开(公告)号：US20180214474A1
公开(公告)日：2018-08-02
申请号：US15823415
申请日：2017-11-27
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： A61K31/713 , C12N15/11 , C12N15/113 , C12N15/82 , C12N15/10
CPC分类号： A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N15/8218 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12N2320/13 , C12N2330/31 , C12Y113/12007 , C12Y502/01008
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for AAT.
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公开(公告)号：US20180119144A1
公开(公告)日：2018-05-03
申请号：US15705650
申请日：2017-09-15
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/113 , A61K31/713 , C12N15/10 , C12N15/11
CPC分类号： C12N15/113 , A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12Y113/12007 , C12Y502/01008
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
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公开(公告)号：US09879266B2
公开(公告)日：2018-01-30
申请号：US14937607
申请日：2015-11-10
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C12N15/11 , C12N15/113 , A61K31/713 , C12N15/10 , C12N15/82
CPC分类号： C12N15/1137 , A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1136 , C12N15/1138 , C12N15/8218 , C12N2310/14 , C12N2310/31 , C12N2310/322 , C12N2320/10 , C12N2320/11 , C12N2320/13 , C12Y113/12007 , C12Y502/01008
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for HAO1.
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