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75 条记录 (耗时 0.034 秒)

    NMR analyzer
    16.
    发明授权
    NMR analyzer 失效

    公开(公告)号：US07208954B2

    公开(公告)日：2007-04-24

    申请号：US10725411

    申请日：2003-12-03

    申请人： Katsuzou Aihara ,  Michiya Okada ,  Shigeru Kakugawa ,  Hiroshi Morita ,  Tsuyoshi Wakuda

    发明人： Katsuzou Aihara ,  Michiya Okada ,  Shigeru Kakugawa ,  Hiroshi Morita ,  Tsuyoshi Wakuda

    IPC分类号： G01V3/00

    CPC分类号： G01R33/34046 ,  G01R33/34053 ,  G01R33/3806 ,  G01R33/3815 ,  G01R33/44 ,  G01R33/4808

    摘要： A first room-temperature space is formed penetrating through a cryostat along a center axis of a split-type multi-layer cylindrical superconducting coil system which has a ratio of the maximum empirical magnetic field to the central magnetic filed of not larger than 1.3 and is horizontally arranged such that the center axis of the coil is in the horizontal direction, a room-temperature shim coil system is arranged in said first room-temperature space to improve the homogeneity of the magnetic field, a second room-temperature space is formed penetrating through the cryostat and passing through the center of said split gap in the vertical direction, and a sample to be measured and an NMR probe having a solenoid-type probe coil are inserted in said second room-temperature space. Further, the NMR analyzer has a new function constituted by a system for irradiating and detecting the electromagnetic waves having wavelengths of shorter than 0.1 mm.

    Supersensitive nuclear magnetic resonance micro imaging apparatus
    17.
    发明授权
    Supersensitive nuclear magnetic resonance micro imaging apparatus 失效
    超敏核磁共振微成像装置

    公开(公告)号：US06975118B2

    公开(公告)日：2005-12-13

    申请号：US10326085

    申请日：2002-12-23

    申请人： Michiya Okada ,  Tsuyoshi Wakuda ,  Shigeru Kakugawa ,  Hiroshi Morita ,  Katsuzou Aihara

    发明人： Michiya Okada ,  Tsuyoshi Wakuda ,  Shigeru Kakugawa ,  Hiroshi Morita ,  Katsuzou Aihara

    IPC分类号： G01R33/465 ,  G01R33/30 ,  G01R33/34 ,  G01R33/3815 ,  G01R33/48 ,  G01R33/56 ,  G01V3/00

    CPC分类号： G01R33/3815 ,  G01R33/465 ,  G01R33/5604

    摘要： It is possible to grasp the behavior of a protein in a cell by realizing a nuclear magnetic resonance imaging method having spatial resolutions on the scale of a cell, and to provide an industrial measure for developing a high-quality protein utilizing this technology. In order to realize spatial resolutions in the order of one-tenth the size of a cell, a supersensitive measurement is realized by the combination of a solenoid detector coil and a high magnetic field NMR of not less than 14 Tesla, which has not been used so far. It is combined with the magnetic field uniformity of 0.001 ppm, so that the supersensitive NMR imaging of 0.5 μm, which has been impossible heretofore, is realized. The physico-chemical behavior of protein molecules can be easily clarified, and thus the bioinfomatic network or the process of metabolism of the cell can be brought out.

    摘要翻译： 通过实现在细胞尺度上具有空间分辨率的核磁共振成像方法，可以掌握细胞中蛋白质的行为，并提供利用该技术开发高质量蛋白质的工业测量方法。 为了实现单元大小十分之一的空间分辨率，通过螺线管检测器线圈和尚未使用的不小于14特斯拉的高磁场NMR的组合来实现超敏感测量 至今。 它与0.001ppm的磁场均匀性相结合，从而实现了迄今为止不可能的0.5mum的超灵敏NMR成像。 蛋白质分子的物理化学性质可以很容易地得到澄清，从而可以推出生物网络或细胞代谢过程。

    Supersensitive nuclear magnetic resonance imaging apparatus
    18.
    发明申请
    Supersensitive nuclear magnetic resonance imaging apparatus 审中-公开
    超敏核磁共振成像装置

    公开(公告)号：US20050248349A1

    公开(公告)日：2005-11-10

    申请号：US11167185

    申请日：2005-06-28

    申请人： Michiya Okada ,  Tsuyoshi Wakuda ,  Shigeru Kakugawa ,  Hiroshi Morita ,  Katsuzou Aihara

    发明人： Michiya Okada ,  Tsuyoshi Wakuda ,  Shigeru Kakugawa ,  Hiroshi Morita ,  Katsuzou Aihara

    IPC分类号： G01R33/465 ,  G01R33/30 ,  G01R33/34 ,  G01R33/3815 ,  G01R33/48 ,  G01R33/56 ,  G01V3/00

    CPC分类号： G01R33/3815 ,  G01R33/465 ,  G01R33/5604

    摘要： A supersensitive nuclear magnetic resonance imaging apparatus includes a superconducting magnet, a gradient magnetic field coil, a high frequency emitting coil, and a receiving coil, wherein a biosample, including at least one of cells, organic tissues, and laboratory small animals, is inserted in a sample chamber of generally 1 to 30 mm in diameter. The superconducting magnet is formed of laterally divided split magnets, and the direction of the magnetic field generated by the magnet is generally horizontal. The receiving coil is in the form of a solenoid coil, and the biosample is inserted from a direction orthogonal to the direction of the magnetic field in a generally vertical direction. The spatial resolution in imaging of the biosample is not more than one-tenth of a cell that forms the biosample.

    摘要翻译： 超灵敏核磁共振成像装置包括超导磁体，梯度磁场线圈，高频发射线圈和接收线圈，其中包括细胞，有机组织和实验室小动物中的至少一个的生物样本被插入 在通常为1至30mm直径的样品室中。 超导磁体由横向分开的分割磁体形成，并且由磁体产生的磁场的方向大致水平。 接收线圈是螺线管线圈的形式，并且生物样本沿着与大致垂直方向的磁场方向正交的方向插入。 生物样品成像中的空间分辨率不超过形成生物样品的细胞的十分之一。

    Split type NMR Superconductive magnet device and NMR apparatus for solution analysis with a permanent current switch holding the split type superconducting magnet in a permanent current mode
    20.
    发明授权
    Split type NMR Superconductive magnet device and NMR apparatus for solution analysis with a permanent current switch holding the split type superconducting magnet in a permanent current mode 失效
    分离式NMR超导磁体装置和用于溶液分析的NMR装置，其中永磁电流开关将分体式超导磁体保持在永久电流模式

    公开(公告)号：US07154271B2

    公开(公告)日：2006-12-26

    申请号：US11348347

    申请日：2006-02-07

    申请人： Shigeru Kakugawa ,  Michiya Okada ,  Katsuzou Aihara ,  Hiroshi Morita ,  Tsuyoshi Wakuda

    发明人： Shigeru Kakugawa ,  Michiya Okada ,  Katsuzou Aihara ,  Hiroshi Morita ,  Tsuyoshi Wakuda

    IPC分类号： G01V3/00

    CPC分类号： G01R33/381 ,  G01R33/3815

    摘要： A superconducting magnet device configured for an NMR spectrometer includes a split type superconducting magnet having left and right solenoid superconducting magnets, wherein the split type superconducting magnet has a center space around a vertical center axis between the left and right solenoid superconducting magnets, a sample tube placed in the center space in order to enable placement of a sample therein, which is energized by the magnetic field generated by the split type superconducting magnet, a solenoid coil configured for detecting signals due to magnetic resonance from the energized sample, and a permanent current switch for holding the split type superconducting magnet to a permanent current mode.

    摘要翻译： 配置用于NMR光谱仪的超导磁体装置包括具有左，右螺线管超导磁体的分体式超导磁体，其中分型超导磁体具有围绕左右螺线管超导磁体之间的垂直中心轴的中心空间，样品管 放置在中心空间中，以便能够通过由分体式超导磁体产生的磁场激励的样品放置在其中，螺线管线圈被配置成用于检测来自通电样品的磁共振的信号，以及永久电流 用于将分离型超导磁体保持在永久电流模式。