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公开(公告)号：US07208954B2
公开(公告)日：2007-04-24
申请号：US10725411
申请日：2003-12-03
IPC分类号： G01V3/00
CPC分类号： G01R33/34046 , G01R33/34053 , G01R33/3806 , G01R33/3815 , G01R33/44 , G01R33/4808
摘要： A first room-temperature space is formed penetrating through a cryostat along a center axis of a split-type multi-layer cylindrical superconducting coil system which has a ratio of the maximum empirical magnetic field to the central magnetic filed of not larger than 1.3 and is horizontally arranged such that the center axis of the coil is in the horizontal direction, a room-temperature shim coil system is arranged in said first room-temperature space to improve the homogeneity of the magnetic field, a second room-temperature space is formed penetrating through the cryostat and passing through the center of said split gap in the vertical direction, and a sample to be measured and an NMR probe having a solenoid-type probe coil are inserted in said second room-temperature space. Further, the NMR analyzer has a new function constituted by a system for irradiating and detecting the electromagnetic waves having wavelengths of shorter than 0.1 mm.
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公开(公告)号：US06975118B2
公开(公告)日：2005-12-13
申请号：US10326085
申请日：2002-12-23
IPC分类号： G01R33/465 , G01R33/30 , G01R33/34 , G01R33/3815 , G01R33/48 , G01R33/56 , G01V3/00
CPC分类号： G01R33/3815 , G01R33/465 , G01R33/5604
摘要： It is possible to grasp the behavior of a protein in a cell by realizing a nuclear magnetic resonance imaging method having spatial resolutions on the scale of a cell, and to provide an industrial measure for developing a high-quality protein utilizing this technology. In order to realize spatial resolutions in the order of one-tenth the size of a cell, a supersensitive measurement is realized by the combination of a solenoid detector coil and a high magnetic field NMR of not less than 14 Tesla, which has not been used so far. It is combined with the magnetic field uniformity of 0.001 ppm, so that the supersensitive NMR imaging of 0.5 μm, which has been impossible heretofore, is realized. The physico-chemical behavior of protein molecules can be easily clarified, and thus the bioinfomatic network or the process of metabolism of the cell can be brought out.
摘要翻译： 通过实现在细胞尺度上具有空间分辨率的核磁共振成像方法，可以掌握细胞中蛋白质的行为，并提供利用该技术开发高质量蛋白质的工业测量方法。 为了实现单元大小十分之一的空间分辨率，通过螺线管检测器线圈和尚未使用的不小于14特斯拉的高磁场NMR的组合来实现超敏感测量 至今。 它与0.001ppm的磁场均匀性相结合，从而实现了迄今为止不可能的0.5mum的超灵敏NMR成像。 蛋白质分子的物理化学性质可以很容易地得到澄清，从而可以推出生物网络或细胞代谢过程。
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公开(公告)号：US20050248349A1
公开(公告)日：2005-11-10
申请号：US11167185
申请日：2005-06-28
IPC分类号： G01R33/465 , G01R33/30 , G01R33/34 , G01R33/3815 , G01R33/48 , G01R33/56 , G01V3/00
CPC分类号： G01R33/3815 , G01R33/465 , G01R33/5604
摘要： A supersensitive nuclear magnetic resonance imaging apparatus includes a superconducting magnet, a gradient magnetic field coil, a high frequency emitting coil, and a receiving coil, wherein a biosample, including at least one of cells, organic tissues, and laboratory small animals, is inserted in a sample chamber of generally 1 to 30 mm in diameter. The superconducting magnet is formed of laterally divided split magnets, and the direction of the magnetic field generated by the magnet is generally horizontal. The receiving coil is in the form of a solenoid coil, and the biosample is inserted from a direction orthogonal to the direction of the magnetic field in a generally vertical direction. The spatial resolution in imaging of the biosample is not more than one-tenth of a cell that forms the biosample.
摘要翻译： 超灵敏核磁共振成像装置包括超导磁体，梯度磁场线圈，高频发射线圈和接收线圈，其中包括细胞，有机组织和实验室小动物中的至少一个的生物样本被插入 在通常为1至30mm直径的样品室中。 超导磁体由横向分开的分割磁体形成，并且由磁体产生的磁场的方向大致水平。 接收线圈是螺线管线圈的形式，并且生物样本沿着与大致垂直方向的磁场方向正交的方向插入。 生物样品成像中的空间分辨率不超过形成生物样品的细胞的十分之一。
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4.发明授权Split type NMR Superconductive magnet device and NMR apparatus for solution analysis with a permanent current switch holding the split type superconducting magnet in a permanent current mode 失效分离式NMR超导磁体装置和用于溶液分析的NMR装置，其中永磁电流开关将分体式超导磁体保持在永久电流模式公开(公告)号：US07154271B2
公开(公告)日：2006-12-26
申请号：US11348347
申请日：2006-02-07
IPC分类号： G01V3/00
CPC分类号： G01R33/381 , G01R33/3815
摘要： A superconducting magnet device configured for an NMR spectrometer includes a split type superconducting magnet having left and right solenoid superconducting magnets, wherein the split type superconducting magnet has a center space around a vertical center axis between the left and right solenoid superconducting magnets, a sample tube placed in the center space in order to enable placement of a sample therein, which is energized by the magnetic field generated by the split type superconducting magnet, a solenoid coil configured for detecting signals due to magnetic resonance from the energized sample, and a permanent current switch for holding the split type superconducting magnet to a permanent current mode.
摘要翻译： 配置用于NMR光谱仪的超导磁体装置包括具有左，右螺线管超导磁体的分体式超导磁体，其中分型超导磁体具有围绕左右螺线管超导磁体之间的垂直中心轴的中心空间，样品管 放置在中心空间中，以便能够通过由分体式超导磁体产生的磁场激励的样品放置在其中，螺线管线圈被配置成用于检测来自通电样品的磁共振的信号，以及永久电流 用于将分离型超导磁体保持在永久电流模式。
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5.发明授权Split type NMR magnet device and NMR apparatus for solution analysis with at least an 11 T static magnetic field and different energizing directions of the NMR magnets 有权分离型NMR磁体装置和用于溶液分析的NMR装置，其具有至少11T静磁场和NMR磁体的不同激励方向公开(公告)号：US07053621B2
公开(公告)日：2006-05-30
申请号：US11078360
申请日：2005-03-14
IPC分类号： G01V3/00
CPC分类号： G01R33/381 , G01R33/3815
摘要： A split type magnet device configured for a high-sensitivity NMR apparatus and used for solution analysis generates a uniform magnetic field at the center portion of the magnet device of at least 11 T, which is used for determining a sample. The NMR magnet device has left and right solenoid superconducting magnets, which face each other with a predetermined distance being provided therebetween. The left solenoid superconducting magnets and the right solenoid superconducting magnets are substantially coaxial to a central axis, and constituted respectively by a plurality of outermost magnets and a separate plurality of innermost magnets. When a sample energizing current generates a main magnetic NMR detection field in the vicinity of a center portion of the apparatus the current direction in at least one of the plurality of innermost magnets is minus while the current direction in at least one of the plurality of outermost magnets is plus.
摘要翻译： 配置用于高灵敏度NMR装置并用于溶液分析的分裂型磁体装置在用于确定样品的至少11T的磁体装置的中心部分处产生均匀的磁场。 NMR磁体装置具有彼此面对的预定距离的左右电磁铁超导磁体。 左电磁铁超导磁体和右螺线管超导磁体基本上与中心轴同轴，并且分别由多个最外面的磁体和分开的多个最内磁体构成。 当样品通电电流在装置的中心部分附近产生主磁NMR检测场时，多个最内磁体中的至少一个磁体中的电流方向为负，而多个最外侧磁体中的至少一个中的电流方向为 磁铁是加号。
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6.发明授权Split type NMR superconductive magnet device and NMR apparatus for solution analysis with different current directions and a permanent current switch 失效分离式NMR超导磁体装置和用于不同电流方向溶液分析的NMR装置和永久电流开关公开(公告)号：US07292040B2
公开(公告)日：2007-11-06
申请号：US11489593
申请日：2006-07-20
IPC分类号： G01V3/00
CPC分类号： G01R33/381 , G01R33/3815
摘要： A superconducting magnet configured for an NMR spectrometer includes a split type superconducting magnet having left solenoid superconducting magnets and right solenoid superconducting magnets with a center space therebetween for receiving a sample tube. A permanent current switch is provided and the left and right solenoid superconducting magnets are arranged symmetrically with respect to a center face of the center space. The left and right solenoid superconducting magnets are constituted by an outermost magnet and a plurality of innermost magnets and are arranged in concentric relation with respect to a vertical axis of the center space. A direction of current in at least one of the plurality of innermost magnets is minus when a direction of current in the outermost magnet is plus.
摘要翻译： 配置用于NMR光谱仪的超导磁体包括具有左螺线管超导磁体和右螺线管超导磁体的分体式超导磁体，其间具有用于接收样品管的中心空间。 提供永久电流开关，左右电磁铁超导磁体相对于中心空间的中心面对称地配置。 左右电磁铁超导磁体由最外侧的磁体和多个最内侧的磁铁构成，并且相对于中心空间的垂直轴以同心的方式配置。 当最外磁体的电流方向为正时，多个最内磁体中的至少一个磁体中的电流方向为负。
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公开(公告)号：US07212003B2
公开(公告)日：2007-05-01
申请号：US11025915
申请日：2005-01-03
IPC分类号： G01V3/00
CPC分类号： G01R33/34046 , G01R33/34053 , G01R33/3806 , G01R33/3815 , G01R33/44 , G01R33/4808
摘要： A first room-temperature space is formed penetrating through a cryostat along a center axis of a split-type multi-layer cylindrical superconducting coil system which has a ratio of the maximum empirical magnetic field to the central magnetic field of not larger than 1.3 and is horizontally arranged such that the center axis of the coil is in the horizontal direction, a room-temperature shim coil system is arranged in said first room-temperature space to improve the homogeneity of the magnetic field, a second room-temperature space is formed penetrating through the cryostat and passing through the center of said split gap in the vertical direction, and a sample to be measured and an NMR probe having a solenoid-type probe coil are inserted in said second room-temperature space. Further, the NMR analyzer has a new function constituted by a system for irradiating and detecting the electromagnetic waves having wavelengths of shorter than 0.1 mm.
摘要翻译： 第一室温空间形成为沿着分离式多层圆柱形超导线圈系统的中心轴穿过低温恒温器，其具有最大经验磁场与中心磁场的比例不大于1.3，并且是 水平排列为使得线圈的中心轴线处于水平方向，在所述第一室温空间内布置室温垫片线圈系统，以改善磁场的均匀性，形成第二室温空间 通过低温恒温器并沿着垂直方向穿过所述分割间隙的中心，并且将待测量样品和具有螺线管型探针线圈的NMR探针插入所述第二室温空间中。 此外，NMR分析仪具有由用于照射和检测波长小于0.1mm的电磁波的系统构成的新功能。
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公开(公告)号：US20060250134A1
公开(公告)日：2006-11-09
申请号：US11489593
申请日：2006-07-20
IPC分类号： G01V3/00
CPC分类号： G01R33/381 , G01R33/3815
摘要： A superconducting magnet configured for an NMR spectrometer includes a split type superconducting magnet having left solenoid superconducting magnets and right solenoid superconducting magnets with a center space therebetween for receiving a sample tube. A permanent current switch is provided and the left and right solenoid superconducting magnets are arranged symmetrically with respect to a center face of the center space. The left and right solenoid superconducting magnets are constituted by an outermost magnet and a plurality of innermost magnets and are arranged in concentric relation with respect to a vertical axis of the center space. A direction of current in at least one of the plurality of innermost magnets is minus when a direction of current in the outermost magnet is plus.
摘要翻译： 配置用于NMR光谱仪的超导磁体包括具有左螺线管超导磁体和右螺线管超导磁体的分体式超导磁体，其间具有用于接收样品管的中心空间。 提供永久电流开关，左右电磁铁超导磁体相对于中心空间的中心面对称地配置。 左右电磁铁超导磁体由最外侧的磁体和多个最内侧的磁铁构成，并且相对于中心空间的垂直轴以同心的方式配置。 当最外磁体的电流方向为正时，多个最内磁体中的至少一个磁体中的电流方向为负。
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公开(公告)号：US20060125478A1
公开(公告)日：2006-06-15
申请号：US11348347
申请日：2006-02-07
IPC分类号： G01V3/00
CPC分类号： G01R33/381 , G01R33/3815
摘要： A superconducting magnet device configured for an NMR spectrometer includes a split type superconducting magnet having left and right solenoid superconducting magnets, wherein the split type superconducting magnet has a center space around a vertical center axis between the left and right solenoid superconducting magnets, a sample tube placed in the center space in order to enable placement of a sample therein, which is energized by the magnetic field generated by the split type superconducting magnet, a solenoid coil configured for detecting signals due to magnetic resonance from the energized sample, and a permanent current switch for holding the split type superconducting magnet to a permanent current mode.
摘要翻译： 配置用于NMR光谱仪的超导磁体装置包括具有左，右螺线管超导磁体的分体式超导磁体，其中分型超导磁体具有围绕左右螺线管超导磁体之间的垂直中心轴的中心空间，样品管 放置在中心空间中，以便能够通过由分体式超导磁体产生的磁场激励的样品放置在其中，螺线管线圈被配置成用于检测来自通电样品的磁共振的信号，以及永久电流 用于将分离型超导磁体保持在永久电流模式。
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公开(公告)号：US20070279059A1
公开(公告)日：2007-12-06
申请号：US11717138
申请日：2007-03-13
IPC分类号： G01R33/44
CPC分类号： G01R33/34046 , G01R33/34053 , G01R33/3806 , G01R33/3815 , G01R33/44 , G01R33/4808
摘要： A first room-temperature space is formed penetrating through a cryostat along a center axis of a split-type multi-layer cylindrical superconducting coil system which has a ratio of the maximum empirical magnetic field to the central magnetic filed of not larger than 1.3 and is horizontally arranged such that the center axis of the coil is in the horizontal direction, a room-temperature shim coil system is arranged in said first room-temperature space to improve the homogeneity of the magnetic field, a second room-temperature space is formed penetrating through the cryostat and passing through the center of said split gap in the vertical direction, and a sample to be measured and an NMR probe having a solenoid-type probe coil are inserted in said second room-temperature space. Further, the NMR analyzer has a new function constituted by a system for irradiating and detecting the electromagnetic waves having wavelengths of shorter than 0.1 mm.
摘要翻译： 第一室温空间形成为沿分离型多层圆柱形超导线圈系统的中心轴穿过低温恒温器，该分离型多层圆柱形超导线圈系统的最大经验磁场与中心磁场的比值不大于1.3， 水平排列为使得线圈的中心轴线处于水平方向，在所述第一室温空间内布置室温垫片线圈系统，以改善磁场的均匀性，形成第二室温空间 通过低温恒温器并沿着垂直方向穿过所述分割间隙的中心，并且将待测量样品和具有螺线管型探针线圈的NMR探针插入所述第二室温空间中。 此外，NMR分析仪具有由用于照射和检测波长小于0.1mm的电磁波的系统构成的新功能。
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