公开(公告)号：US20230192900A1

公开(公告)日：2023-06-22

申请号：US17929028

申请日：2020-02-13

Applicant: UCB BIOPHARMA SRL

Inventor： David Alan COOK ,  Helen Margaret FINNEY ,  Stephen Edward RAPECKI

IPC: C07K16/46

CPC classification number: C07K16/468 ,  C07K2317/31 ,  C07K2317/24 ,  C07K2317/94 ,  C07K2317/565

Abstract: The present invention relates to multispecific antibodies against a novel targets' combination of HVEM and CD9, and their use in the treatment of cancer and infectious diseases.

公开(公告)号：US20230194541A1

公开(公告)日：2023-06-22

申请号：US17823356

申请日：2022-08-30

Applicant: UCB BIOPHARMA SRL

Inventor： James Philip O'CONNELL ,  John Robert PORTER ,  Alastair LAWSON ,  Boris KROEPLIEN ,  Stephen Edward RAPECKI ,  Timothy John NORMAN ,  Graham John WARRELLOW

IPC: G01N33/68 ,  C07D401/14 ,  C07K14/525 ,  C07D471/00 ,  C07K14/705 ,  C07K16/24 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D471/04 ,  A61K47/64 ,  A61P37/00 ,  A61P35/00

CPC classification number: G01N33/6845 ,  C07D401/14 ,  C07K14/525 ,  C07D471/00 ,  C07K14/70575 ,  C07K16/241 ,  G01N33/6863 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D471/04 ,  G01N33/6854 ,  A61K47/6425 ,  A61P37/00 ,  A61P35/00 ,  G01N2500/02 ,  G01N2333/525 ,  C07K2317/55 ,  C07K2317/92

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. Anew assay for identifying compounds with this mechanism of action is also disclosed.

公开(公告)号：US20200157215A1

公开(公告)日：2020-05-21

申请号：US16778523

申请日：2020-01-31

Applicant: UCB Biopharma SRL

Inventor： Helene Margaret FINNEY ,  Stephen Edward RAPECKI ,  Kerry Louise TYSON ,  Michael John WRIGHT

IPC: C07K16/28 ,  A01K67/027

Abstract: The present disclosure relates to antibody molecules comprising a binding domain specific to CD22, said binding domain comprising SEQ ID NO: 1, 2, 3, 4, 5 and 6 or 7. The disclosure also extends to pharmaceutical compositions comprising said antibody molecules and use of the antibody molecules/compositions in treatment.