公开(公告)号：US20230065921A1

公开(公告)日：2023-03-02

申请号：US17821688

申请日：2022-08-23

申请人： UCB Biopharma SRL

发明人： Helene Margaret FINNEY ,  Stephen Edward RAPECKI ,  Kerry Louise TYSON ,  Michael John WRIGHT

IPC分类号： C07K16/28 ,  A01K67/027

摘要： The present disclosure relates to antibody molecules comprising a binding domain specific to CD22, said binding domain comprising SEQ ID NO: 1, 2, 3, 4, 5 and 6 or 7. The disclosure also extends to pharmaceutical compositions comprising said antibody molecules and use of the antibody molecules/compositions in treatment.

公开(公告)号：US20230287134A1

公开(公告)日：2023-09-14

申请号：US18153181

申请日：2023-01-11

申请人： UCB BIOPHARMA SRL

发明人： Helene Margaret FINNEY ,  Stephen Edward RAPECKI ,  Kerry Louise TYSON ,  Michael John WRIGHT

IPC分类号： C07K16/28 ,  C07K16/18

CPC分类号： C07K16/289 ,  C07K16/18 ,  C07K16/2803 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/35 ,  C07K2317/64 ,  C07K2317/624

摘要： The present disclosure relates to constructs, such as antibody molecules comprising a binding domain specific to CD45, said binding domain comprising SEQ ID NO: 1, 2, 3 and/or SEQ ID NO: 4, 5 and 6. The disclosure also extends to pharmaceutical compositions comprising said constructs and use of the constructs/compositions in treatment.

公开(公告)号：US20210262024A1

公开(公告)日：2021-08-26

申请号：US17255316

申请日：2019-07-03

申请人： UCB BIOPHARMA SRL

发明人： Daniel John LIGHTWOOD ,  Michael John WRIGHT

IPC分类号： C12Q1/6869 ,  C12Q1/6806

摘要： The present disclosure relates to a duplex probe molecule comprising: i) a double-stranded-core (the core) comprising a first polynucleotide strand (first-strand) and a second polynucleotide strand (second-strand), wherein the first and second strands are complementary to each other, ii) a single stranded first polynucleotide probe (first probe) sequence extending in the 5′ to 3′ direction from the first-strand of the core; and iii) single stranded second polynucleotide probe (second probe) sequence extending in the 5′ to 3′ direction from the second strand of the core; wherein the first and second probes extend outwards from the double stranded core in opposing directions on different polynucleotide strands and each terminate in a 3′ end. The disclosure also extends to methods of making the molecule and use of the molecule, for example to capture variable domains sequence information from antibodies.

公开(公告)号：US20200157215A1

公开(公告)日：2020-05-21

申请号：US16778523

申请日：2020-01-31

申请人： UCB Biopharma SRL

发明人： Helene Margaret FINNEY ,  Stephen Edward RAPECKI ,  Kerry Louise TYSON ,  Michael John WRIGHT

IPC分类号： C07K16/28 ,  A01K67/027

摘要： The present disclosure relates to antibody molecules comprising a binding domain specific to CD22, said binding domain comprising SEQ ID NO: 1, 2, 3, 4, 5 and 6 or 7. The disclosure also extends to pharmaceutical compositions comprising said antibody molecules and use of the antibody molecules/compositions in treatment.