专利检索 ap:("UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION") AND inv:"Donna M. Huryn" 第 2 页

11.

发明授权
6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity 有权

公开(公告)号：US11111253B2

公开(公告)日：2021-09-07

申请号：US16846089

申请日：2020-04-10

申请人： UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Donna M. Huryn , Peter Wipf , Jennifer Rubin Grandis , Matthew G. LaPorte , Paul A. Johnston , Mark E. Schurdak , Raffaele Colombo

IPC分类号： C07D513/04 , A61P35/00

摘要： Compounds that selectivity inhibit the STAT3 pathway and not the STAT1 pathway and exhibit anti-proliferative activity are disclosed. Also disclosed are methods of treatment of cancers that are characterized by overexpression of STAT3, which are safer that other therapies.

12.

发明申请
6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as Inhibitors of the STAT3 Pathway with Anti-Proliferative Activity 审中-公开

公开(公告)号：US20200339602A1

公开(公告)日：2020-10-29

申请号：US16846089

申请日：2020-04-10

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Donna M. Huryn , Peter Wipf , Jennifer Rubin Grandis , Matthew G. LaPorte , Paul A. Johnston , Mark E. Schurdak , Raffaele Colombo

IPC分类号： C07D513/04 , A61P35/00

摘要： Compounds that selectivity inhibit the STAT3 pathway and not the STAT1 pathway and exhibit anti-proliferative activity are disclosed. Also disclosed are methods of treatment of cancers that are characterized by overexpression of STAT3, which are safer that other therapies.

13.

发明申请
MODULATORS OF P97 AAA ATPASE ACTIVITY 审中-公开

公开(公告)号：US20200216410A1

公开(公告)日：2020-07-09

申请号：US16612342

申请日：2018-05-10

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Donna M. Huryn , Peter Wipf , Matthew G. LaPorte

IPC分类号： C07D401/04 , C07D401/14

摘要： The present technology is directed to methods of inhibiting or modulating p97 and compounds and compositions useful in such methods Diseases and conditions that can be treated with the compounds and compositions of the present technology include, but are not limited to, antibacterial infection, antiviral infection, cancer and neurodegenerative disorders susceptible to treatment by inhibition or modulation of p97.

14.

发明申请
6-ARYL-7-SUBSTITUTED-3-(1H-PYRAZOL-5-YL)-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZINES AS INHIBITORS OF THE STAT3 PATHWAY WITH ANTI-PROLIFERATIVE ACTIVITY 审中-公开

公开(公告)号：US20190100535A1

公开(公告)日：2019-04-04

申请号：US15543573

申请日：2016-01-15

申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Donna M. Huryn , Peter Wipf , Jennifer Rubin Grandis , Matthew G. LaPorte , Paul A. Johnston , Mark E. Schurdak , Raffaele Colombo

IPC分类号： C07D513/04 , A61P35/00

摘要： Compounds that selectivity inhibit the STAT3 pathway and not the STAT1 pathway and exhibit anti-proliferative activity are disclosed. Also disclosed are methods of treatment of cancers that are characterized by overexpression of STAT3, which are safer that other therapies.