公开(公告)号：US20210032221A1

公开(公告)日：2021-02-04

申请号：US17046255

申请日：2019-04-11

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Donna M. Huryn ,  Peter Wipf

IPC分类号： C07D401/14

摘要： The present technology is directed to methods of inhibiting or modulating p97 and compounds and compositions useful in such methods. Diseases and conditions that can be treated with the compounds and compositions of the present technology include, but are not limited to, antibacterial infection, antiviral infection, cancer and neurodegenerative disorders susceptible to treatment by modulation of p97.

公开(公告)号：US11214560B2

公开(公告)日：2022-01-04

申请号：US16612342

申请日：2018-05-10

申请人： UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Donna M. Huryn ,  Peter Wipf ,  Matthew G. LaPorte

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  A61P35/00 ,  A61P31/18

摘要： The present technology is directed to methods of inhibiting or modulating p97 and compounds and compositions useful in such methods Diseases and conditions that can be treated with the compounds and compositions of the present technology include, but are not limited to, antibacterial infection, antiviral infection, cancer and neurodegenerative disorders susceptible to treatment by inhibition or modulation of p97.

公开(公告)号：US10894782B2

公开(公告)日：2021-01-19

申请号：US16301080

申请日：2017-05-11

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Donna M. Huryn ,  Peter Wipf ,  Matthew G. LaPorte

IPC分类号： C07D401/04 ,  A61K31/4196 ,  A61K45/06 ,  A61K31/44 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention is directed to methods of inhibiting or modulating p97 and compounds and compositions useful in such methods. Diseases and conditions that can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by modulation or inhibition of p97.

公开(公告)号：US20200157082A1

公开(公告)日：2020-05-21

申请号：US16748654

申请日：2020-01-21

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education ,  National Institutes of Health, A Component of the U.S. Department of Health and Human Services ,  The Regents of the University of California

发明人： Donna M. Huryn ,  Peter Wipf ,  Matthew G. LaPorte ,  Raffaele Colombo ,  Marina Kovaliov ,  Chaemin Lim ,  Celeste Natalie Alverez ,  Zhizhou Yue ,  Lalith Palitha Samankumara ,  Alexander Julian Chatterley ,  Yongzhao Yan ,  Mary Liang ,  Neal J. Green ,  Eric T. Baldwin ,  William J. Moore ,  Michelle Arkin ,  R. Jeffrey Neitz ,  Kean-Hooi Ang ,  Clifford Bryant ,  Stacie Bulfer

IPC分类号： C07D405/14 ,  C07D417/14 ,  C07D413/14 ,  A61P35/00 ,  A61P25/28 ,  C07D401/10 ,  C07D401/14

摘要： The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.

公开(公告)号：US20240051931A1

公开(公告)日：2024-02-15

申请号：US18039941

申请日：2021-12-02

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Peter Wipf ,  Donna M. Huryn ,  Matthew G. LaPorte ,  Leila Terrab ,  Michael James Houghton ,  Andrea Topacio ,  Taber Sarah Maskrey ,  Tyler Kristufek ,  Uygar Sozer ,  Desirae Lynn Crocker ,  Sipak Joyasawal ,  Alyssa Thornton ,  Shikha Singh Chauhan ,  Mary Liang ,  Prema Iyer ,  Jagannath Panda

IPC分类号： C07D311/66 ,  C07D405/12 ,  C07D265/36 ,  C07D405/04

CPC分类号： C07D311/66 ,  C07D405/12 ,  C07D265/36 ,  C07D405/04

摘要： The present disclosure is directed to chromane compounds, chromane compounds demonstrating HDAC inhibition, and pharmaceutical compositions thereof. Additional embodiments include methods of using the chromane compounds. For example, the disclosure includes methods of inhibiting histone acetylation in a cell, comprising contacting the cell with a chromane compound of the disclosure. Additional embodiments include methods of treating a disease capable of treatment by inhibition of histone acetylation in a patient in need thereof, comprising administering a chromane compound of the disclosure.

公开(公告)号：US11718600B2

公开(公告)日：2023-08-08

申请号：US17046255

申请日：2019-04-11

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Donna M. Huryn ,  Peter Wipf

IPC分类号： C07D401/14

CPC分类号： C07D401/14 ,  C07B2200/05

摘要： The present technology is directed to methods of inhibiting or modulating p97 and compounds and compositions useful in such methods. Diseases and conditions that can be treated with the compounds and compositions of the present technology include, but are not limited to, antibacterial infection, antiviral infection, cancer and neurodegenerative disorders susceptible to treatment by modulation of p97.

公开(公告)号：US11247985B2

公开(公告)日：2022-02-15

申请号：US16748654

申请日：2020-01-21

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education ,  National Institutes of Health, A Component of the United States Department of Health and Human Services ,  The Regents of the University of California

发明人： Donna M. Huryn ,  Peter Wipf ,  Matthew G. LaPorte ,  Raffaele Colombo ,  Marina Kovaliov ,  Chaemin Lim ,  Celeste Natalie Alverez ,  Zhizhou Yue ,  Lalith Palitha Samankumara ,  Alexander Julian Chatterley ,  Yongzhao Yan ,  Mary Liang ,  Neal J. Green ,  Eric T. Baldwin ,  William J. Moore ,  Michelle Arkin ,  R. Jeffrey Neitz ,  Kean-Hooi Ang ,  Clifford Bryant ,  Stacie Bulfer

IPC分类号： C07D401/10 ,  A61P35/00 ,  C07D405/14 ,  C07D401/14 ,  A61P25/28 ,  C07D413/14 ,  C07D417/14

摘要： The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.

公开(公告)号：US11773075B2

公开(公告)日：2023-10-03

申请号：US17544863

申请日：2021-12-07

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Donna M. Huryn ,  Peter Wipf ,  Matthew G. LaPorte

IPC分类号： C07D401/04 ,  C07D401/14 ,  A61P31/18 ,  A61P31/00 ,  A61P35/00 ,  C07D405/14

CPC分类号： C07D401/04 ,  C07D401/14

摘要： The present technology is directed to methods of inhibiting or modulating p97 and compounds and compositions useful in such methods. Diseases and conditions that can be treated with the compounds and compositions of the present technology include, but are not limited to, antibacterial infection, antiviral infection, cancer and neurodegenerative disorders susceptible to treatment by inhibition or modulation of p97.

公开(公告)号：US20220112179A1

公开(公告)日：2022-04-14

申请号：US17556147

申请日：2021-12-20

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education ,  National Institutes of Health, A component of the United States Department of Health and Human Servi ,  The Regents of the University of California

发明人： Donna M. Huryn ,  Peter Wipf ,  Matthew G. LaPorte ,  Raffaele Colombo ,  Marina Kovaliov ,  Chaemin Lim ,  Celeste Natalie Alverez ,  Zhizhou Yue ,  Lalith Palitha Samankumara ,  Alexander Julian Chatterley ,  Yongzhao Yan ,  Mary Liang ,  Neal J. Green ,  Eric T. Baldwin ,  William J. Moore ,  Michelle Arkin ,  R. Jeffrey Neitz ,  Kean-Hooi Ang ,  Clifford Bryant ,  Stacie Bulfer

IPC分类号： C07D405/14 ,  A61P35/00 ,  C07D401/10 ,  C07D413/14 ,  C07D401/14 ,  C07D417/14 ,  A61P25/28

摘要： The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.

公开(公告)号：US20220089565A1

公开(公告)日：2022-03-24

申请号：US17544863

申请日：2021-12-07

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Donna M. Huryn ,  Peter Wipf ,  Matthew G. LaPorte

IPC分类号： C07D401/04 ,  C07D401/14

摘要： The present technology is directed to methods of inhibiting or modulating p97 and compounds and compositions useful in such methods. Diseases and conditions that can be treated with the compounds and compositions of the present technology include, but are not limited to, antibacterial infection, antiviral infection, cancer and neurodegenerative disorders susceptible to treatment by inhibition or modulation of p97.