公开(公告)号：US12240880B2

公开(公告)日：2025-03-04

申请号：US17698553

申请日：2022-03-18

Applicant: UNIVERSITY OF WASHINGTON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Daniel Adriano Silva Manzano ,  Shawn Yu ,  Umut Ulge ,  David Baker ,  Kenan Christopher Garcia ,  Jamie Spangler ,  Carl Walkey

IPC: C07K14/55 ,  A61K38/00 ,  A61K47/60 ,  A61K47/62 ,  C07K14/54

Abstract: De novo designed polypeptides that bind to IL-2 receptor βc heterodimer (IL-2Rβc), IL-4 receptor αc heterodimer (IL-4Rαc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.

公开(公告)号：US20230340071A1

公开(公告)日：2023-10-26

申请号：US17908844

申请日：2021-03-12

Applicant: Neoleukin Therapeutics, Inc. ,  University of Washington

Inventor： Daniel Adriano Silva Manzano ,  Alfredo Quijano Rubio ,  Jesus Renan Vergara Gutierrez ,  Thomas Linsky ,  Jorgen Nelson

IPC: C07K14/715

CPC classification number: C07K14/7155 ,  A61K38/00

Abstract: The present invention is related to, inter alia, de novo IL-2R13 binding polypeptides.

公开(公告)号：US20220056095A1

公开(公告)日：2022-02-24

申请号：US17473731

申请日：2021-09-13

Applicant: UNIVERSITY OF WASHINGTON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Daniel Adriano Silva Manzano ,  Shawn Yu ,  David Baker ,  Kenan Christopher Garcia ,  Jamie Spangler ,  Alfredo Quijano Rubio

IPC: C07K14/55 ,  C07K14/54 ,  A61K47/62 ,  A61K47/60

Abstract: De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγcheterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.

公开(公告)号：US10703791B2

公开(公告)日：2020-07-07

申请号：US16572038

申请日：2019-09-16

Applicant: UNIVERSITY OF WASHINGTON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Daniel Adriano Silva Manzano ,  Shawn Yu ,  Umut Ulge ,  David Baker ,  Kenan Christopher Garcia ,  Jamie Spangler ,  Carl Walkey

IPC: C07K14/55 ,  C07K14/54 ,  A61K38/00

Abstract: De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγc heterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.