公开(公告)号：US20240025843A1

公开(公告)日：2024-01-25

申请号：US18228192

申请日：2023-07-31

Applicant: University of Florida Research Foundation, Inc.

Inventor： Alexander James Grenning

IPC: C07C253/30 ,  C07B37/02 ,  C07C255/31 ,  C07C255/47 ,  C07D221/22 ,  C07D307/94 ,  C07D311/94 ,  C07D317/72 ,  C07C403/18

CPC classification number: C07C253/30 ,  C07B37/02 ,  C07C255/31 ,  C07C255/47 ,  C07D221/22 ,  C07D307/94 ,  C07D311/94 ,  C07D317/72 ,  C07C403/18 ,  C07C2602/30 ,  C07C2603/30 ,  C07C2602/32 ,  C07C2602/34 ,  C07C2601/16 ,  C07C2601/14

Abstract: In one aspect, the disclosure relates to methods for preparation of terpene and terpene-like molecules. In a further aspect, the disclosure relates to the products of the disclosed methods, i.e., terpene and terpene-like molecules prepared using the disclosed methods. Intermediates for the synthesis of a wide variety of terpenoids are γ-allyl Knoevenagel adducts or quasi γ-allyl Knoevenagel adducts are disclosed. In various aspects, methods of preparing terpenoids through these intermediates are disclosed. The methods can comprise α-alkylation of an allylic electrophile followed by ring-closure metathesis to a polycyclic terpenoid structure. In a further aspect, the disclosure pertains to terpenoid frameworks, and compounds prepared via disclosed oxidation and substitution reactions on the disclosed terpenoid frameworks. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20230064185A1

公开(公告)日：2023-03-02

申请号：US17950772

申请日：2022-09-22

Applicant: University of Florida Research Foundation, Inc.

Inventor： Alexander James Grenning ,  Sarah Scott

IPC: C07C253/30 ,  C07C255/31 ,  C07C255/47 ,  C07D227/04

Abstract: In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, such as 6/7/5 tricycloalkanes. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to tunably and scalably assemble common terpenoid cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US10894763B2

公开(公告)日：2021-01-19

申请号：US16567643

申请日：2019-09-11

Applicant: University of Florida Research Foundation, Inc.

Inventor： Alexander James Grenning ,  Sarah Scott

IPC: C07C253/30 ,  C07C255/47 ,  C07C255/31 ,  C07D227/04

Abstract: In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, such as 6/7/5 tricycloalkanes. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to tunably and scalably assemble common terpenoid cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.