公开(公告)号：US10287239B1

公开(公告)日：2019-05-14

申请号：US15981833

申请日：2018-05-16

Applicant: University of Florida Research Foundation, Inc.

Inventor： Alexander James Grenning ,  Sarah Scott

IPC: C07C253/30 ,  C07C255/31 ,  C07C255/47 ,  C07D227/04

Abstract: In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, such as 6/7/5 tricycloalkanes. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to tunably and scalably assemble common terpenoid cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20190270700A1

公开(公告)日：2019-09-05

申请号：US16333728

申请日：2017-09-15

Applicant: University of Florida Research Foundation, Inc.

Inventor： Alexander James Grenning

IPC: C07C253/30 ,  C07C255/31 ,  C07C255/47 ,  C07D221/22 ,  C07D307/94 ,  C07D311/94 ,  C07B37/02

Abstract: In one aspect, the disclosure relates to methods for preparation of terpene and terpene-like molecules. In a further aspect, the disclosure relates to the products of the disclosed methods, i.e., terpene and terpene-like molecules prepared using the disclosed methods. Intermediates for the synthesis of a wide variety of terpenoids are γ-allyl Knoevenagel adducts or quasi γ-allyl Knoevenagel adducts are disclosed. In various aspects, methods of preparing terpenoids through these intermediates are disclosed. The methods can comprise a-alkylation of an allylic electrophile followed by ring-closure metathesis to a polycyclic terpenoid structure. In a further aspect, the disclosure pertains to terpenoid frameworks, and compounds prepared via disclosed oxidation and substitution reactions on the disclosed terpenoid frameworks. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US12098115B2

公开(公告)日：2024-09-24

申请号：US18228192

申请日：2023-07-31

Applicant: University of Florida Research Foundation, Inc.

Inventor： Alexander James Grenning

IPC: C07C255/31 ,  C07B37/02 ,  C07C253/30 ,  C07C255/47 ,  C07C403/18 ,  C07D221/22 ,  C07D307/94 ,  C07D311/94 ,  C07D317/72

CPC classification number: C07C253/30 ,  C07B37/02 ,  C07C255/31 ,  C07C255/47 ,  C07C403/18 ,  C07D221/22 ,  C07D307/94 ,  C07D311/94 ,  C07D317/72 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/30 ,  C07C2602/32 ,  C07C2602/34 ,  C07C2603/30

Abstract: In one aspect, the disclosure relates to methods for preparation of terpene and terpene-like molecules. In a further aspect, the disclosure relates to the products of the disclosed methods, i.e., terpene and terpene-like molecules prepared using the disclosed methods. Intermediates for the synthesis of a wide variety of terpenoids are γ-allyl Knoevenagel adducts or quasi γ-allyl Knoevenagel adducts are disclosed. In various aspects, methods of preparing terpenoids through these intermediates are disclosed. The methods can comprise α-alkylation of an allylic electrophile followed by ring-closure metathesis to a polycyclic terpenoid structure. In a further aspect, the disclosure pertains to terpenoid frameworks, and compounds prepared via disclosed oxidation and substitution reactions on the disclosed terpenoid frameworks. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20210179546A1

公开(公告)日：2021-06-17

申请号：US17183978

申请日：2021-02-24

Applicant: University of Florida Research Foundation, Inc.

Inventor： Alexander James Grenning ,  Sarah Scott

IPC: C07C253/30 ,  C07C255/31 ,  C07C255/47 ,  C07D227/04

Abstract: In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, such as 6/7/5 tricycloalkanes. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to tunably and scalably assemble common terpenoid cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US11485704B2

公开(公告)日：2022-11-01

申请号：US17183978

申请日：2021-02-24

Applicant: University of Florida Research Foundation, Inc.

Inventor： Alexander James Grenning ,  Sarah Scott

IPC: C07C255/31 ,  C07C255/47 ,  C07D227/04 ,  C07C253/30

Abstract: In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, such as 6/7/5 tricycloalkanes. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to tunably and scalably assemble common terpenoid cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US11008283B2

公开(公告)日：2021-05-18

申请号：US17013902

申请日：2020-09-08

Applicant: University of Florida Research Foundation, Inc.

Inventor： Alexander James Grenning ,  Sarah Scott

IPC: C07C255/31 ,  C07C253/30 ,  C07D227/04 ,  C07C255/47

Abstract: In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, such as 6/7/5 tricycloalkanes. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to tunably and scalably assemble common terpenoid cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20200002272A1

公开(公告)日：2020-01-02

申请号：US16567643

申请日：2019-09-11

Applicant: University of Florida Research Foundation, Inc.

Inventor： Alexander James Grenning ,  Sarah Scott

IPC: C07C253/30 ,  C07C255/31 ,  C07C255/47 ,  C07D227/04

Abstract: In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, such as 6/7/5 tricycloalkanes. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to tunably and scalably assemble common terpenoid cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20190352254A1

公开(公告)日：2019-11-21

申请号：US16383425

申请日：2019-04-12

Applicant: University of Florida Research Foundation, Inc.

Inventor： Alexander James Grenning ,  Sarah Scott

IPC: C07C253/30 ,  C07C255/47 ,  C07D227/04 ,  C07C255/31

Abstract: In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, such as 6/7/5 tricycloalkanes. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to tunably and scalably assemble common terpenoid cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20240376041A1

公开(公告)日：2024-11-14

申请号：US18782144

申请日：2024-07-24

Applicant: University of Florida Research Foundation, Inc.

Inventor： Alexander James Grenning

IPC: C07C253/30 ,  C07B37/02 ,  C07C255/31 ,  C07C255/47 ,  C07C403/18 ,  C07D221/22 ,  C07D307/94 ,  C07D311/94 ,  C07D317/72

Abstract: In one aspect, the disclosure relates to methods for preparation of terpene and terpene-like molecules. In a further aspect, the disclosure relates to the products of the disclosed methods, i.e., terpene and terpene-like molecules prepared using the disclosed methods. Intermediates for the synthesis of a wide variety of terpenoids are γ-allyl Knoevenagel adducts or quasi γ-allyl Knoevenagel adducts are disclosed. In various aspects, methods of preparing terpenoids through these intermediates are disclosed. The methods can comprise α-alkylation of an allylic electrophile followed by ring-closure metathesis to a polycyclic terpenoid structure. In a further aspect, the disclosure pertains to terpenoid frameworks, and compounds prepared via disclosed oxidation and substitution reactions on the disclosed terpenoid frameworks. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US11952327B2

公开(公告)日：2024-04-09

申请号：US16333728

申请日：2017-09-15

Applicant: University of Florida Research Foundation, Inc.

Inventor： Alexander James Grenning

IPC: C07C253/30 ,  C07B37/02 ,  C07C255/31 ,  C07C255/47 ,  C07C403/18 ,  C07D221/22 ,  C07D307/94 ,  C07D311/94 ,  C07D317/72

CPC classification number: C07C253/30 ,  C07B37/02 ,  C07C255/31 ,  C07C255/47 ,  C07C403/18 ,  C07D221/22 ,  C07D307/94 ,  C07D311/94 ,  C07D317/72 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/30 ,  C07C2602/32 ,  C07C2602/34 ,  C07C2603/30

Abstract: In one aspect, the disclosure relates to methods for preparation of terpene and terpene-like molecules. In a further aspect, the disclosure relates to the products of the disclosed methods, i.e., terpene and terpene-like molecules prepared using the disclosed methods. Intermediates for the synthesis of a wide variety of terpenoids are γ-allyl Knoevenagel adducts or quasi γ-allyl Knoevenagel adducts are disclosed. In various aspects, methods of preparing terpenoids through these intermediates are disclosed. The methods can comprise α-alkylation of an allylic electrophile followed by ring-closure metathesis to a polycyclic terpenoid structure. In a further aspect, the disclosure pertains to terpenoid frameworks, and compounds prepared via disclosed oxidation and substitution reactions on the disclosed terpenoid frameworks. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.