公开(公告)号：US12195472B2

公开(公告)日：2025-01-14

申请号：US17518732

申请日：2021-11-04

Applicant: Vanderbilt University

Inventor： Taekyu Lee ,  Zhiguo Bian ,  Johannes Belmar ,  Plamen P. Christov ,  Nicholas F. Pelz ,  Subrata Shaw ,  Kwangho Kim ,  James C. Tarr ,  Edward T. Olejniczak ,  Bin Zhao ,  Stephen W. Fesik

IPC: C07D487/04 ,  A61K31/381 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/4155 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D209/42 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D471/04

Abstract: The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.

公开(公告)号：US12144816B2

公开(公告)日：2024-11-19

申请号：US18064206

申请日：2022-12-09

Applicant: Vanderbilt University

Inventor： Taekyu Lee ,  James C. Tarr ,  KyuOk Jeon ,  James M. Salovich ,  Subrata Shaw ,  Nagarathanam Veerasamy ,  Kwangho Kim ,  Plamen P. Christov ,  Edward T. Olejniczak ,  Bin Zhao ,  Stephen W. Fesik ,  Zhiguo Bian

IPC: A61K31/551 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  A61K45/06 ,  A61P35/00 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D487/04 ,  C07D519/00

Abstract: The present disclosure provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present disclosure also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.

公开(公告)号：US20230330099A1

公开(公告)日：2023-10-19

申请号：US18064206

申请日：2022-12-09

Applicant: Vanderbilt University

Inventor： Taekyu Lee ,  James C. Tarr ,  KyuOk Jeon ,  James M. Salovich ,  Subrata Shaw ,  Nagarathanam Veerasamy ,  Kwangho Kim ,  Plamen P. Christov ,  Edward T. Olejniczak ,  Bin Zhao ,  Stephen W. Fesik ,  Zhiguo Bian

IPC: A61K31/551 ,  A61P35/00 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D487/04 ,  C07D519/00

CPC classification number: A61K31/551 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  A61K45/06 ,  A61P35/00 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D487/04 ,  C07D519/00

Abstract: The present disclosure provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present disclosure also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.

公开(公告)号：US09949965B2

公开(公告)日：2018-04-24

申请号：US14885181

申请日：2015-10-16

Applicant: Vanderbilt University

Inventor： Taekyu Lee ,  Jason P. Burke ,  Edward T. Olejniczak ,  Johannes Belmar ,  Zhiguo Bian ,  Stephen W. Fesik

IPC: A61K31/554 ,  A61K31/542 ,  A61K31/4745 ,  C07D513/06 ,  C07D471/08 ,  C07D498/06 ,  A61K31/5383 ,  A61K45/06

CPC classification number: A61K31/4745 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/554 ,  A61K45/06 ,  C07D471/08 ,  C07D498/06 ,  C07D513/06

Abstract: The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.