公开(公告)号：US08147880B2

公开(公告)日：2012-04-03

申请号：US12766895

申请日：2010-04-25

Applicant: Wen-Chin Yang

Inventor： Wen-Chin Yang

IPC: A61K36/00

CPC classification number: A61K36/28 ,  A61K31/7034 ,  Y10S514/866

Abstract: This invention relates to a method of treating type II diabetes with a polyacetylenic compound of the following formula: in which R1 is H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C1-C20 heterocycloalkyl, C1-C20 heterocycloalkenyl, aryl, or heteroaryl; R2 is H or a monosaccharide residue; R3 is H or C1-C10 alkyl; m is 2, 3, or 4; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, or 4; and p is 1, 2, 3, or 4.

Abstract translation: 本发明涉及用下式的聚乙炔化合物治疗II型糖尿病的方法：其中R1是H，C1-C10烷基，C2-C10链烯基，C2-C10炔基，C3-C20环烷基，C3-C20环烯基 ，C 1 -C 20杂环烷基，C 1 -C 20杂环烯基，芳基或杂芳基; R2是H或单糖残基; R3是H或C1-C10烷基; m为2,3或4; n为0,1,2或3; o为0,1,2,3或4; 而p为1,2,3或4。

公开(公告)号：US20090062216A1

公开(公告)日：2009-03-05

申请号：US12263896

申请日：2008-11-03

Applicant: Wen-Chin Yang ,  Shu-Lin Chang ,  Lee-Tian Chang ,  Yi-Ming Chiang ,  Lie-Fen Shyur

Inventor： Wen-Chin Yang ,  Shu-Lin Chang ,  Lee-Tian Chang ,  Yi-Ming Chiang ,  Lie-Fen Shyur

IPC: A61K31/7028 ,  A61P37/00

CPC classification number: A61K36/28 ,  C07H15/10

Abstract: A method of treating a Th1-mediated disorder includes administering to a subject in need of the treatment an effective amount of a compound of the formula I: wherein R1 is H, alkyl, aryl, or cyclyl; R2 is pyranose; R3 is H or alkyl; m is 2, 3, 4, 5, or 6; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, 4; p is 1, 2, 3, or 4; and the Th1-mediated disorder is non-obese diabetes, Crohn's colitis, autoimmune hemolytic anemia, rheumatoid arthritis, autoimmune encephalitis, multiple sclerosis, or autoimmune myocarditis. Also disclosed is a pharmaceutical composition including a compound of formula I above and a pharmaceutically acceptable carrier.

Abstract translation: 治疗Th1介导的病症的方法包括向需要治疗的受试者施用有效量的式I化合物：其中R 1是H，烷基，芳基或环基; R2是吡喃糖; R3是H或烷基; m为2,3,4,5或6; n为0,1,2或3; o是0，1，2，3，4; p是1,2,3或4; 并且Th1介导的病症是非肥胖性糖尿病，克罗恩病的结肠炎，自身免疫性溶血性贫血，类风湿性关节炎，自身免疫性脑炎，多发性硬化或自身免疫性心肌炎。 还公开了包含上述式I化合物和药学上可接受的载体的药物组合物。

公开(公告)号：US20080193568A1

公开(公告)日：2008-08-14

申请号：US11674105

申请日：2007-02-12

Applicant: Wen-Chin Yang ,  Lee-Tian Chang

Inventor： Wen-Chin Yang ,  Lee-Tian Chang

IPC: A61K36/185 ,  C07H15/04 ,  A61K31/70

CPC classification number: A61K36/28 ,  A61K31/7034 ,  Y10S514/866

Abstract: This invention relates to a method of treating type II diabetes with a polyacetylenic compound of the following formula: in which R1 is H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C1-C20 heterocycloalkyl, C1-C20 heterocycloalkenyl, aryl, or heteroaryl; R2 is H or a monosaccharide residue; R3 is H or C1-C10alkyl; m is 2, 3, or 4; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, or 4; and p is 1, 2, 3, or 4.

Abstract translation: 本发明涉及用下式的聚乙炔化合物治疗II型糖尿病的方法：其中R 1是H，C 1 -C 10烷基， C 1 -C 12烷基，C 2 -C 10链烯基，C 2 -C 10炔基，C <亚<！ - SIPO < C 3 -C 20环烷基，C 3 -C 20环烯基，C 1 -C 20个杂环烷基，C 1 -C 20杂环烯基，芳基或杂芳基; R 2是H或单糖残基; R 3是H或C 1 -C 10烷基; m为2,3或4; n为0,1,2或3; o为0,1,2,3或4; 而p为1,2,3或4。

公开(公告)号：US20070048395A1

公开(公告)日：2007-03-01

申请号：US11215765

申请日：2005-08-30

Applicant: Wen-Chin Yang ,  Shu-Lin Chang

Inventor： Wen-Chin Yang ,  Shu-Lin Chang

IPC: A61K36/28 ,  A61K31/7048

CPC classification number: A61K36/28 ,  A61K31/7048 ,  Y02A50/478 ,  A61K2300/00

Abstract: A method for treating a bacterial infection in a subject by administration of an effective amount of centaurein alone or in combination with a bacteriocide. Also described is a composition containing an effective combined amount of centaurein and a bacteriocide useful for treating a bacterial infection in a subject.

Abstract translation: 通过单独施用有效量的百吗百醇或与杀细菌剂组合来治疗受试者的细菌感染的方法。 还描述了含有有效组合量的百里灵素和可用于治疗受试者细菌感染的杀菌剂的组合物。

公开(公告)号：US06184652B2

公开(公告)日：2001-02-06

申请号：US09552009

申请日：2000-04-19

Applicant: Wen-Chin Yang

Inventor： Wen-Chin Yang

IPC: H01M1046

CPC classification number: H02J7/0052 ,  H02J2007/006

Abstract: This invention relates to a Mobile phone battery charger with USB interface which is composed of a compatible plug, an DC converter and a Mobile phone battery charging plug. The compatible plug can be inserted into the USB interface socket of computer or any environmental equipment so as to get electric power from computer, furthermore, the DC converter can convert computer USB interface into necessary charging voltage and transmit to different type Mobile phone by means of the Mobile phone battery charging plug for charging Mobile phone battery. In addition, the Mobile phone battery charger with USB interface also can be connected to various Mobile phone battery charging seat for charging.

Abstract translation: 本发明涉及具有USB接口的手机电池充电器，其由兼容插头，DC转换器和手机电池充电插头组成。 兼容插头可插入计算机或任何环境设备的USB接口插座，以便从计算机获取电力，此外，DC转换器可将计算机USB接口转换为必要的充电电压，并通过 手机电池充电插头用于充电手机电池。 另外手机电池充电器带USB接口也可以连接各种手机充电座充电。