公开(公告)号：US20230416290A1

公开(公告)日：2023-12-28

申请号：US18335136

申请日：2023-06-15

Applicant: West China Hospital, Sichuan University

Inventor： Zhiyao He ,  Yuquan Wei

IPC: C07H15/18 ,  C08B37/00 ,  C07H15/10 ,  C07H15/04 ,  C07C269/06

CPC classification number: C07H15/18 ,  C08B37/0087 ,  C07H15/10 ,  C07H15/04 ,  C07C269/06

Abstract: Disclosed is a method for preparing an N-acetyl-D-galactosamine tripolymer precursor. In the preparation of the tripolymer precursor, a compound 4 is prepared by the following steps: adding a compound 3, a 4Å molecular sieve powder, and a reaction solvent into a reactor; inflating and changing protective gas for 3 times; stirring; firstly adding an enol, followed by slowly dropping trimethylsilyl trifluoromethanesulfonate; after a reaction, quenching the reaction with an alkali solution; and performing extraction, separating liquid, washing, drying, filtration, etc., so as to obtain the compound 4. According to the present disclosure, the problems of various production processes, more times of column chromatography for purification of products accompanied by lower yields in the prior art are solved.

公开(公告)号：US20230183284A1

公开(公告)日：2023-06-15

申请号：US17798397

申请日：2021-02-10

Applicant: GLYCOSCIENCE, S.L.

Inventor： Peter William SUTTON

IPC: C07H15/207 ,  C07H15/10 ,  C07H15/26 ,  C07H15/18 ,  C07H15/203 ,  A01N33/22 ,  A01N31/16 ,  A01N31/08 ,  A01N31/02 ,  A01N43/40 ,  A01N31/04 ,  A01P17/00

CPC classification number: C07H15/207 ,  C07H15/10 ,  C07H15/26 ,  C07H15/18 ,  C07H15/203 ,  A01N33/22 ,  A01N31/16 ,  A01N31/08 ,  A01N31/02 ,  A01N43/40 ,  A01N31/04 ,  A01P17/00

Abstract: The present invention relates to a 3′-ketoglycoside compound defined by formula (I) and its use for controlled release of alcohols, in particular alcohols showing an insect repellent effect. It relates also to a process for preparing the 3′-ketoglycoside compound of formula (I). It further relates to a composition comprising a 3′-ketoglycoside compound of formula (I). It relates also to the use of a 3′-ketoglycoside compound of formula (I) for the controlled release of alcohols. It related also to a method of use of such composition.

公开(公告)号：US09873713B2

公开(公告)日：2018-01-23

申请号：US14405092

申请日：2014-10-10

Applicant: Zhejiang University

Inventor： Shengming Ma ,  Xin Huang ,  Chunling Fu

IPC: C07H15/18 ,  C07H15/10 ,  C07C29/46 ,  C07C2/86 ,  C07C303/40 ,  C07C231/12 ,  C07C269/06 ,  C07C67/30 ,  C07H1/00 ,  C07C37/14 ,  C07H15/14 ,  C07C29/32 ,  C07C67/343

CPC classification number: C07H15/18 ,  C07B2200/07 ,  C07C2/867 ,  C07C29/32 ,  C07C29/46 ,  C07C37/14 ,  C07C67/30 ,  C07C67/343 ,  C07C231/12 ,  C07C269/06 ,  C07C303/40 ,  C07C2527/122 ,  C07C2601/14 ,  C07H1/00 ,  C07H15/10 ,  C07H15/14 ,  C07C33/02 ,  C07C33/30 ,  C07C33/14 ,  C07C33/38 ,  C07C69/602 ,  C07C69/608 ,  C07C311/16 ,  C07C233/65 ,  C07C271/12 ,  C07C15/44

Abstract: The present invention relates to a process for efficiently synthesizing highly optically active 1,3-disubstituted allenes, i.e., a one-step process for preparing highly optically active 1,3-disubstituted allenes by using a functionalized terminal alkyne, an aldehyde and a chiral α,α-diphenyl prolinol as reactants under the catalysis of a divalent copper salt. The operation of the process is simple, and the raw materials and reagents are readily available. The process has a broad-spectrum of substrates and a good compatibility for a wide variety of functional groups such as glycosidic units, primary alcohols, secondary alcohols, tertiary alcohols, amides, malonates, etc., and does not require the protection for the functional groups. The obtained axially chiral allene has a moderate to high yield and a good diastereoselectivity or enantioselectivity.

公开(公告)号：US09556282B2

公开(公告)日：2017-01-31

申请号：US14965264

申请日：2015-12-10

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Yu-Ying Hsu ,  Te-Yi Chang ,  Ju-Feng Liao ,  Sheng-Ju Liao ,  Yao-Jheng Huang

IPC: C08B3/10 ,  C08G81/02 ,  C08B3/12 ,  C08L1/10 ,  C08L23/10 ,  C07H15/20 ,  C08L23/12 ,  C07H15/10 ,  C07H15/04

CPC classification number: C08B3/10 ,  C07H15/04 ,  C07H15/10 ,  C07H15/20 ,  C08B3/12 ,  C08G81/02 ,  C08G81/024 ,  C08L1/10 ,  C08L23/10 ,  C08L23/12

Abstract: A modified cellulose is provided. The modified cellulose is represented by the chemical formula (1): wherein n is between 60 and 2500, at least one R is selected from one of the group consisting of R1 is C11 to C32 alkyl group or C11 to C32 alkenyl group, R2 is hydrogen, C3 to C29 alkyl group or C3 to C29 alkenyl group, R3 is C3 to C29 alkyl group or C3 to C29 alkenyl group, R4 is C4 to C8 cycloalkyl group or C4 to C8 cycloalkenyl group, n2 is between 15 and 33, n4 is between 20 and 40.

Abstract translation: 提供了改性纤维素。 改性纤维素由化学式（1）表示：其中n为60至2500，至少一个R选自R1为C11至C32烷基或C11至C32烯基，R2为 氢，C3至C29烷基或C3至C29烯基，R3为C3至C29烷基或C3至C29烯基，R4为C4至C8环烷基或C4至C8环烯基，n2为15至33，n4 在20到40之间。

公开(公告)号：US09498490B2

公开(公告)日：2016-11-22

申请号：US14136347

申请日：2013-12-20

Applicant: LABORATOIRE MEDIDOM SA

Inventor： Stefano Carlino ,  René-Pierre Bunter

IPC: A61K31/7032 ,  A61P25/00 ,  C07H1/06 ,  C07H15/10

CPC classification number: A61K31/7032 ,  C07H15/10

Abstract: A process for preparing pure monosialoganglioside GM1 in the form of its sodium salt. There is provided a process for the isolation and purification of monosialoganglioside GM1 comprising (a) separation of GM1 from a lipidic mixture containing the monosialoganglioside GM1 as the main ganglioside component by ion exchange column-chromatography using an eluent comprising potassium or caesium ions, (b) recovery of the solute from the eluted solution, (c) diafiltration of an aqueous solution of the recovered solute, and (d) second diafiltration after the addition of 1 M NaCl, and recovering GM1. The purity level of GM1 obtained is higher than 99.0%.

Abstract translation: 一种以其钠盐形式制备纯唾液酸神经节苷脂GM1的方法。 提供了一种用于分离和纯化单唾液酸神经节苷脂GM1的方法，其包括（a）通过使用包含钾或铯离子的洗脱液的离子交换柱色谱法分离GM1从含有单唾液酸神经节苷脂GM1作为主要神经节苷脂组分的脂质混合物（b ）从洗脱的溶液中回收溶质，（c）渗滤回收的溶质的水溶液，和（d）在加入1M NaCl后进行第二次渗滤，并回收GM1。 获得的GM1纯度高于99.0％。

公开(公告)号：US20160200756A1

公开(公告)日：2016-07-14

申请号：US14995064

申请日：2016-01-13

Applicant: Elevance Renewable Sciences, Inc.

Inventor： Ryan A. Littich ,  Jonathan Brekan ,  Timothy Montavon

IPC: C07H15/10

CPC classification number: C07H15/10 ,  C07H1/00

Abstract: An alkenyl glycoside is prepared by reacting a metathesis-derived unsaturated fatty alcohol containing 10 to 30 carbon atoms with either (1) a reducible monosaccharide or composition hydrolyzable to a reducible monosaccharide, or (2) a hydrocarbyl glycoside produced by reacting an alcohol containing up to 6 carbon atoms with a reducible monosaccharide or composition hydrolyzable to a reducible monosaccharide. Each of these reactions is performed in the presence of an acid catalyst and under conditions sufficient to form the alkenyl glycoside or hydrocarbyl glycoside. The preferred alkenyl glycosides are 9-decen-1-yl glycoside; 9-dodecen-1-yl glycoside; 9-tridecen-1-yl glycoside; 9-pentadecen-1-yl glycoside; 9-octadecen-yl glycoside; or 9-octadecen-1,18-diyl glycoside.

Abstract translation: 通过使含有10〜30个碳原子的复分解衍生的不饱和脂肪醇与（1）可还原的单糖或可还原的单糖可水解的组合物反应来制备烯基糖苷，或（2）通过使含有酒精的醇反应生成的烃基糖苷 至6个碳原子，可还原的单糖或组合物可水解成可还原的单糖。 这些反应都是在酸催化剂存在下和足以形成烯基糖苷或烃基糖苷的条件下进行的。 优选的烯基糖苷是9-癸烯-1-基苷; 9-十二碳烯-1-基苷; 9-十三碳烯-1-基苷; 9-十五碳烯-1-基苷; 9-十八烯酸苷; 或9-十八碳烯-1,18-二基糖苷。

公开(公告)号：US20160193310A1

公开(公告)日：2016-07-07

申请号：US14392341

申请日：2014-06-26

Applicant: Chi-Huey WONG ,  Chung-Yi WU ,  Hong-Yang CHUANG ,  Chien-Tai REN ,  ACADEMIA SINICA

Inventor： Chi-Huey WONG ,  Chung-Yi WU ,  Hong-Yang CHUANG ,  Chien-Tai REN

IPC: A61K39/00 ,  A61K49/00 ,  C07H15/14 ,  C07H15/10

CPC classification number: A61K39/0011 ,  A61K31/7028 ,  A61K39/385 ,  A61K49/00 ,  A61K2039/575 ,  A61K2039/585 ,  A61K2039/6037 ,  A61K2039/627 ,  C07H15/04 ,  C07H15/10 ,  C07H15/14 ,  C07K14/4748

Abstract: Described herein are synthetic glycan conjugates, immmunogenic compositions thereof, vaccines thereof, and kits thereof. The present invention further provides methods of using the synthetic glycan conjugates, immunogenic compositions, or vaccines thereof to treat and/or prevent and/or diagnose proliferative diseases such as cancer. The provided glycan conjugate comprises a carrier and a glycan moiety of Formula (I-i) or Formula (I-ii): (structurally represented).

Abstract translation: 本文描述的是合成聚糖缀合物，其免疫原性组合物，其疫苗及其试剂盒。 本发明还提供了使用合成聚糖缀合物，免疫原性组合物或其疫苗来治疗和/或预防和/或诊断增殖性疾病如癌症的方法。 所提供的聚糖缀合物包含式（I-i）或式（I-ii）的载体和聚糖部分：（结构上表示）。

公开(公告)号：US09382566B1

公开(公告)日：2016-07-05

申请号：US14041786

申请日：2013-09-30

Applicant: The United States of America, as represented by the Secretary of Agriculture

Inventor： Cletus P. Kurtzman ,  Neil P. Price ,  Karen J. Ray ,  Tsung Min Kuo

IPC: C12P19/44 ,  C12R1/72 ,  C07H15/10 ,  C07H15/06 ,  C07H15/04 ,  C12R1/22

CPC classification number: C12P19/44 ,  C07H1/00 ,  C07H15/04 ,  C07H15/06 ,  C07H15/10 ,  C12R1/22 ,  C12R1/72

Abstract: Open chain sophorolipids may be produced by fermentation with Candida sp. NRRL Y-27208 or C. riodocensis. Dimers and trimers of sophorolipids are also produced. The sophorolipds are produced by inoculating a fermentation medium comprising a carbon source and a lipid, with Candida riodocensis or Candida species NRRL Y-27208, and incubating under aerobic conditions and for a period of time effective to produce an open chain sophorolipid in the medium. The sophorolipids may be subsequently recovered from the fermentation medium.

Abstract translation: 开放链槐糖可以通过用念珠菌sp。 NRRL Y-27208或C. riodocensis。 还生产了槐糖脂的二聚体和三聚体。 通过将含有碳源和脂质的发酵培养基与假丝酵母或假丝酵母属NRRL Y-27208接种，并在需氧条件下孵育一段时间以有效地在培养基中产生开链槐糖脂来制备槐果胶。 随后可以从发酵培养基中回收槐糖脂。

公开(公告)号：US20160160163A1

公开(公告)日：2016-06-09

申请号：US15041396

申请日：2016-02-11

Applicant: WAKAYAMA UNIVERSITY

Inventor： Masanori YAMAGUCHI

IPC: C12M1/40 ,  C12M1/00

CPC classification number: C12M21/18 ,  C07H13/04 ,  C07H15/10 ,  C07H15/26 ,  C07H17/02 ,  C12M47/12 ,  C12P19/26

Abstract: The present invention provides a novel sialo-sugar chain, a process for producing the sialo-sugar chain, and a device for producing the sialo-sugar chain. A sialo-sugar chain can be easily and efficiently mass-produced by reacting a sugar wherein a hydroxy groups is substituted with an alkynyl group (herein sometimes referred to as “alkynylated sugar”) with a specific sialic acid donor in the presence of a sialic acid-introducing enzyme.

Abstract translation: 本发明提供了一种新的唾液糖链，唾液糖链的制备方法和唾液糖链的制备装置。 唾液糖链可以通过在唾液酸存在下，使羟基被炔基（有时称为“炔化糖”）与特定的唾液酸供体反应的糖反应而大量生产 酸引入酶。

公开(公告)号：US20160129029A1

公开(公告)日：2016-05-12

申请号：US14934888

申请日：2015-11-06

Applicant: BMB Patent Holding Corporation

Inventor： Barry Miles Belgorod

IPC: A61K31/7016

CPC classification number: A61K31/7016 ,  A61K31/70 ,  A61K31/7028 ,  A61K36/81 ,  A61K45/06 ,  C07H3/04 ,  C07H15/10

Abstract: The present invention discloses the use of certain compounds as therapeutic agents, and in particular as analgesics and anti-inflammatory agents. Such compounds include, for example, certain diterpene monoglycosides and diterpene diglycosides. The compounds of the present invention may be synthesized or isolated from the fruit of the genus Capsicum, and in particular may be isolated from sweet bell peppers (C. annuum). Pharmaceutically-acceptable salts, enantiomers, diasteriomers, racemic mixtures, enantomerically-enriched mixtures, solvates, and prodrug s of such compounds are also disclosed. Pharmaceutical compositions and methods of using such compounds, including pharmaceutical compositions and methods of using such compounds in combination with one or more active ingredients, are also disclosed.

Abstract translation: 本发明公开了某些化合物作为治疗剂，特别是镇痛药和抗炎剂的用途。 这些化合物包括例如某些二萜单糖苷和二萜二糖苷。 本发明的化合物可以从辣椒属的果实中合成或分离，并且特别可以与甜甜椒（C. annuum）分离。 还公开了药学上可接受的盐，对映异构体，非对映异构体，外消旋混合物，富集烯醇的混合物，溶剂合物和这些化合物的前药。 还公开了使用这些化合物的药物组合物和方法，包括药物组合物和使用这些化合物与一种或多种活性成分组合的方法。