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Patent Agency Ranking
公开(公告)号：US20120322762A1
公开(公告)日：2012-12-20
申请号：US13592228
申请日：2012-08-22
Applicant: Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
Inventor： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
IPC: A61K31/69
CPC classification number: A61K9/08 , A61K9/0019 , A61K9/19 , A61K31/4965 , A61K31/69 , A61K47/10 , C07B63/04
Abstract: Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.
Abstract translation: 硼替佐米的多剂量制剂被提出，其中硼替佐米具有显着改善的稳定性。 特别优选的制剂包括硼替佐米是适合注射的液体形式的制剂，其中溶剂体系主要包含丙二醇。 在其他优选方面，硼替佐米作为具有异双功能路易斯碱的路易斯供体 - 受体复合物存在。
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公开(公告)号：US08263578B2
公开(公告)日：2012-09-11
申请号：US13431313
申请日：2012-03-27
Applicant: Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
Inventor： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
IPC: A01N55/08 , A61K31/69 , A61K31/4965 , C07F5/02 , C07F5/04 , C07F7/02 , C07D241/00 , C07D241/02
CPC classification number: A61K9/08 , A61K9/0019 , A61K9/19 , A61K31/4965 , A61K31/69 , A61K47/10 , C07B63/04
Abstract: Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.
Abstract translation: 硼替佐米的多剂量制剂被提出，其中硼替佐米具有显着改善的稳定性。 特别优选的制剂包括硼替佐米是适合注射的液体形式的制剂，其中溶剂体系主要包含丙二醇。 在其他优选方面，硼替佐米作为具有异双功能路易斯碱的路易斯供体 - 受体复合物存在。
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公开(公告)号：US09968614B2
公开(公告)日：2018-05-15
申请号：US15419191
申请日：2017-01-30
Applicant: InnoPharma, Inc.
Inventor： Tushar Hingorani , Kumaresh Soppimath , Satish Pejaver , Navneet Puri
IPC: A61K31/5377 , A61K9/00 , A61K47/26 , A61K9/08 , A61K47/10
CPC classification number: A61K31/5377 , A61K9/0019 , A61K9/08 , A61K47/10 , A61K47/18 , A61K47/24 , A61K47/26 , A61K47/44
Abstract: An aqueous stable and ready-to-use formulation of aprepitant is prepared. Especially preferred formulations comprise a synergistic combination of a co-solvent and a surfactant and may further include a secondary co-solvent. Among other advantages of contemplated formulations, aprepitant is dissolved at high concentrations and remains dissolved and stable, even over prolonged periods of time.
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公开(公告)号：US20170202901A1
公开(公告)日：2017-07-20
申请号：US15478472
申请日：2017-04-04
Applicant: InnoPharma, Inc.
Inventor： Ketan Hippalgaonkar , Kumaresh Soppimath , Satish Pejaver , Navneet Puri
Abstract: The invention relates to pharmaceutical compositions that provide improved solubility and stability for peptide epoxy ketones. More specifically, the invention relates to pharmaceutical compositions comprising the peptide epoxy ketone proteasome inhibitor carfilzomib.
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公开(公告)号：US09636376B2
公开(公告)日：2017-05-02
申请号：US14023247
申请日：2013-09-10
Applicant: InnoPharma, Inc.
Inventor： Ketan Hippalgaonkar , Kumaresh Soppimath , Satish Pejaver , Navneet Puri
Abstract: The invention relates to pharmaceutical compositions that provide improved solubility and stability for peptide epoxy ketones. More specifically, the invention relates to pharmaceutical compositions comprising the peptide epoxy ketone proteasome inhibitor carfilzomib.
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