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公开(公告)号：US09808436B2
公开(公告)日：2017-11-07
申请号：US15271460
申请日：2016-09-21
Applicant: CymaBay Therapeutics, Inc.
Inventor： Pol Boudes , Charles A. McWherter
IPC: A61K31/19 , A61K31/192 , A61K31/09
CPC classification number: A61K31/192 , A61K31/09
Abstract: Treatment of intrahepatic cholestatic diseases by therapy with MBX-8025 or an MBX-8025 salt.
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公开(公告)号：US20160324811A1
公开(公告)日：2016-11-10
申请号：US14995024
申请日：2016-01-13
Applicant: CymaBay Therapeutics, Inc.
Inventor： David Karpf , Ronald M. Krauss , Yun-Jung Choi , Xueyan Wang , Francine M. Gregoire
IPC: A61K31/192 , A61K31/4015
CPC classification number: A61K31/192 , A61K31/09 , A61K31/4015
Abstract: The present invention provides methods for increasing LDL particle size.
Abstract translation: 本发明提供了增加LDL粒径的方法。
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公开(公告)号：US09486428B2
公开(公告)日：2016-11-08
申请号：US14663027
申请日：2015-03-19
Applicant: CymaBay Therapeutics, Inc.
Inventor： Pol Boudes , Charles A. McWherter
IPC: A61K31/19 , A61K31/192 , A61K31/09
CPC classification number: A61K31/192 , A61K31/09
Abstract: Treatment of intrahepatic cholestatic diseases by therapy with MBX-8025 or an MBX-8025 salt.
Abstract translation: 用MBX-8025或MBX-8025盐治疗肝内胆汁淤积性疾病。
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公开(公告)号：US09233914B2
公开(公告)日：2016-01-12
申请号：US14631629
申请日：2015-02-25
Applicant: CymaBay Therapeutics, Inc. , Diatex, Inc.
Inventor： Edward D. Daugs , Eric J. Hagen , Jason A. Hanko , David H. Louks
IPC: C07C67/02 , C07C233/18 , C07C235/78
CPC classification number: C07C233/18 , A61K9/0053 , A61K31/216 , C07B2200/07 , C07B2200/13 , C07C235/78
Abstract: The present invention provides crystalline solid and amorphous forms of (−)-halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to Type 2 diabetes and hyperlipidemia. The invention also relates to a method for preventing or treating Type 2 diabetes and hyperlipidemia in a mammal comprising the step of administering a therapeutically effective amount of crystalline solid and amorphous forms of (−)-halofenate.
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25.发明授权Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts 有权取代的四唑-1-基 - 苯氧基甲基 - 噻唑-2-基 - 哌啶基 - 嘧啶盐公开(公告)号：US08815886B2
公开(公告)日：2014-08-26
申请号：US13853000
申请日：2013-03-28
Applicant: Jiangao Song , Charles A. McWherter , Fang Ma , Mark Andres , Igor Ivanisevic , Ekaterina Albert , Patricia Andres
Inventor： Jiangao Song , Charles A. McWherter , Fang Ma , Mark Andres , Igor Ivanisevic , Ekaterina Albert , Patricia Andres
IPC: A01N43/54 , A61K31/505
CPC classification number: C07D417/14 , A61K31/506 , A61K45/06 , C07B2200/13 , C07D513/14
Abstract: Crystalline salts of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine, compositions thereof, methods for their preparation, and methods for their use are disclosed.
Abstract translation: 5-乙基-2- {4- [4-（4-四唑-1-基 - 苯氧基甲基） - 噻唑-2-基] - 哌啶-1-基} - 嘧啶的结晶盐，其组合物，其制备方法 ，并公开了其使用方法。
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Patent Agency Ranking
公开(公告)号：US11179359B2
公开(公告)日：2021-11-23
申请号：US16906296
申请日：2020-06-19
Applicant: CymaBay Therapeutics, Inc.
Inventor： Brian Roberts , Xueyan Wang , Yun-Jung Choi , David Karpf , Robert Martin , Charles McWherter
IPC: A61K31/192 , A61K31/33 , A61K9/00
Abstract: Treatment of NAFLD and NASH by therapy with MBX-8025 or an MBX-8025 salt.
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公开(公告)号：US20210145774A1
公开(公告)日：2021-05-20
申请号：US17096217
申请日：2020-11-12
Applicant: CymaBay Therapeutics, Inc.
Inventor： Edward E. Cable
IPC: A61K31/192 , A61P1/16
Abstract: Treatment of alcoholic liver disease with seladelpar or a salt thereof.
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公开(公告)号：US10813896B2
公开(公告)日：2020-10-27
申请号：US16676014
申请日：2019-11-06
Applicant: CymaBay Therapeutics, Inc.
Inventor： Pol Boudes , Charles A. McWherter
IPC: A61K31/192 , A61P1/16 , A61K9/48 , A61K9/00
Abstract: Treatment of intrahepatic cholestatic diseases by therapy with seladelpar or a salt thereof.
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公开(公告)号：US10813895B2
公开(公告)日：2020-10-27
申请号：US16597313
申请日：2019-10-09
Applicant: CymaBay Therapeutics, Inc.
Inventor： Pol Boudes , Charles A. McWherter
IPC: A61K31/192 , A61K9/00
Abstract: Treatment of intrahepatic cholestatic diseases by therapy with seladelpar or a salt thereof.
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公开(公告)号：US10272058B2
公开(公告)日：2019-04-30
申请号：US15496875
申请日：2017-04-25
Applicant: CymaBay Therapeutics, Inc.
Inventor： Pol Boudes , Charles A. McWherter
IPC: A61K31/192 , A61K9/00
Abstract: Treatment of intrahepatic cholestatic diseases by therapy with seladelpar or a salt thereof.
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