公开(公告)号：US4314998A

公开(公告)日：1982-02-09

申请号：US123812

申请日：1980-02-22

Applicant: Yuichi Yamamura ,  Akira Hasegawa ,  Ichiro Azuma ,  Shigeru Kobayashi

Inventor： Yuichi Yamamura ,  Akira Hasegawa ,  Ichiro Azuma ,  Shigeru Kobayashi

IPC: C07H15/04 ,  C07K9/00 ,  A61K37/00 ,  A61K37/02 ,  C07C103/52

CPC classification number: C07H15/04 ,  C07K9/005

Abstract: Novel 6-deoxyglucosamine-peptide derivatives of the formula ##STR1## wherein R is hydrogen or an organic acid residue or alkoxycarbonyl;R.sup.1 is hydrogen or acyl;R.sup.2 is hydrogen or lower alkyl;R.sup.3 and R.sup.4 are each hydrogen or lower alkyl which may be substituted with hydroxyl;R.sup.5 and R.sup.6 are each carboxyl which may be esterified or amidated;R.sup.7 is hydrogen or aralkyl; and(D) and (L) each indicate configurations if theirrespective carbon atoms are asymmetric or a salt thereof having immunostimulatory activity.

Abstract translation: 新颖的6-脱氧葡糖胺肽衍生物，其中R为氢或有机酸残基或烷氧基羰基; R1是氢或酰基; R2是氢或低级烷基; R3和R4各自为氢或可被羟基取代的低级烷基; R5和R6各自为可被酯化或酰胺化的羧基; R7是氢或芳烷基; 和（D）和（L）各自表示各自的碳原子不对称的构型或其具有免疫刺激活性的盐。

公开(公告)号：US4243663A

公开(公告)日：1981-01-06

申请号：US931050

申请日：1978-08-04

Applicant: Ichiro Azuma ,  Yuichi Yamamura

Inventor： Ichiro Azuma ,  Yuichi Yamamura

IPC: A61K31/70 ,  A61K35/74 ,  A61K39/00 ,  A61K39/39 ,  C07H13/06 ,  C12P19/00 ,  C07H13/02 ,  A61K31/71 ,  A61K31/72

CPC classification number: C07H13/06 ,  A61K31/70 ,  A61K35/74 ,  A61K39/39 ,  C12P19/00 ,  A61K2039/55511 ,  A61K2039/55572

Abstract: A composition which is capable of specifically inducing an immunity when administered into the body of a host in association with a tumor antigen, or which is capable of non-specifically enhancing an immunizing function when administered into the body of a tumor-carrying host, comprising a glycolipid as active ingredient in association with a pharmaceutically acceptable carrier, wherein the saccharide moiety of the glycolipid is selected from the group consisting of fructose, glucose and sucrose.

Abstract translation: 当与肿瘤抗原结合施用于宿主体内时能够特异性诱导免疫的组合物，或当被施用于携带肿瘤的宿主的体内能够非特异性增强免疫功能的组合物，其包含 糖脂作为活性成分与药学上可接受的载体结合，其中糖脂的糖部分选自果糖，葡萄糖和蔗糖。

公开(公告)号：US4101536A

公开(公告)日：1978-07-18

申请号：US809245

申请日：1977-06-23

Applicant: Yuichi Yamamura ,  Tetsuo Shiba ,  Ichiro Azuma ,  Shoichi Kusumoto ,  Tadamasa Hirayama ,  Tsuneo Kusama

Inventor： Yuichi Yamamura ,  Tetsuo Shiba ,  Ichiro Azuma ,  Shoichi Kusumoto ,  Tadamasa Hirayama ,  Tsuneo Kusama

IPC: A61K38/14 ,  C07K9/00 ,  A61K37/00 ,  C07G7/00

CPC classification number: C07K9/005

Abstract: Muramyldipeptide derivatives of the formula: ##STR1## wherein Y represents a mycoloyl group or a synthetic higher acyl group having total carbon number of C30-C90 and having at least a branched chain of long alkyl group on the .alpha.-position thereof,Q represents an -L-alanyl-D-isoglutamine group, a -glycyl-D-isoglutamine group or an -L-seryl-D-isoglutamine group;Salts of such derivatives; the method of preparing such derivatives and their salts; the derivatives and their salts having potent immunoadjuvant activities and antitumor activity and being applicable as the agent for the immunotherapy of cancer for humans and animals.

Abstract translation: 其中Y表示总碳数为C30-C90并且在其α-位上具有至少一个长烷基的支链的合成的较高级酰基，其中Y代表一个或多个烷基， -L-丙氨酰-D-异谷氨酰胺基，α-甘氨酰-D-异谷氨酸胺基或-L-丝氨酰-D-异谷氨酰胺基; 这些衍生物的销售; 制备这些衍生物及其盐的方法; 衍生物及其具有免疫功能活动和抗肿瘤活性的药物，适用于人类和动物免疫球蛋白的代理。