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    Novel method of inducing antigen-specific t cells
    2.
    发明申请
    Novel method of inducing antigen-specific t cells 审中-公开
    诱导抗原特异性T细胞的新方法

    公开(公告)号：US20050002951A1

    公开(公告)日：2005-01-06

    申请号：US10490865

    申请日：2002-09-27

    Applicant: Haruo Sugiyama ,  Ichiro Azuma

    Inventor： Haruo Sugiyama ,  Ichiro Azuma

    IPC: A61K39/00 ,  A61P35/00 ,  A61K39/02

    CPC classification number: A61K39/0011 ,  A61K2039/545 ,  A61K2039/55594

    Abstract: The present invention provides a novel method for inducing antigen-specific T cells. A method for inducing antigen-specific T cells in a patient comprising administering to said patient in need thereof composition (a) which comprises a therapeutically effective amount of an antigen protein or an antigen peptide as an active ingredient, and composition (b) which comprises a therapeutically effective amount of a cell wall skeleton integrant of the BCG strain of Mycobacterium bovis as an active ingredient, wherein composition (b) is administered in advance and then composition (a) is administered, and related pharmaceutical compositions are provided.

    Abstract translation: 本发明提供了诱导抗原特异性T细胞的新方法。 一种用于在患者中诱导抗原特异性T细胞的方法，包括向所述需要的患者施用组合物（a），其包含治疗有效量的作为活性成分的抗原蛋白或抗原肽，以及组合物（b），其包含 治疗有效量的牛分枝杆菌BCG菌株的细胞壁骨架组合物作为活性成分，其中组合物（b）预先施用，然后施用组合物（a），并提供相关的药物组合物。

    Glucosamine peptide derivatives, their production and use
    3.
    发明授权
    Glucosamine peptide derivatives, their production and use 失效
    葡萄糖胺衍生物，其生产和使用

    公开(公告)号：US4369178A

    公开(公告)日：1983-01-18

    申请号：US123401

    申请日：1980-02-21

    Applicant: Yuichi Yamamura ,  Ichiro Azuma ,  Shigeru Kobayashi

    Inventor： Yuichi Yamamura ,  Ichiro Azuma ,  Shigeru Kobayashi

    IPC: A61K31/70 ,  A61K31/7024 ,  A61K31/7028 ,  A61K38/00 ,  A61K39/39 ,  A61P35/00 ,  A61P37/00 ,  A61P37/04 ,  C07H13/04 ,  C07H13/08 ,  C07H15/04 ,  C07H15/18 ,  C07K1/113 ,  C07K9/00 ,  A61K37/00 ,  C07C103/52

    CPC classification number: C07K9/005

    Abstract: Novel glucosamine-peptide derivatives of the formula: ##STR1## wherein m is 0 or 1;n is 0 or an integer of 1 to 9;R is lower alkyl which may be substituted with hydroxyl, or aryl;R.sup.1 is hydrogen or acyl having an acyclic hydrocarbon group, the terminal of which may be substituted with a cyclic hydrocarbon group directly, via a carbonyl group or via an oxygen atom;provided that when R.sup.1 is hydrogen m is 1;R.sup.2 is hydrogen or lower alkyl which may form a ring by connecting its terminal with the .alpha.-nitrogen atom whenn is 0, or hydrogen when n is an integer of 1 to 9;R.sup.3 is hydrogen or lower alkyl;R.sup.4 and R.sup.5 are each hydrogen or lower alkyl which may be substituted with hydroxyl or benzyloxyl;R.sup.6 is hydrogen or lower alkyl;R.sup.7 is alkyl which may be substituted with lower alkoxyl or aralkyl;R.sup.8 and R.sup.9 are each hydrogen, lower alkyl or aralkyl; and(D) and (L) each indicate configurations if their respective carbon atoms are asymmetric;or an acid addition salt thereof, have immunostimulatory activity.

    Abstract translation: 下式的新型葡糖胺肽衍生物：其中m为0或1; n为0或1〜9的整数。 R是可被羟基或芳基取代的低级烷基; R1是氢或具有非环状烃基的酰基，其末端可以被环状烃基直接经由羰基或氧原子取代; 条件是当R1为氢时m为1; R2为氢或低级烷基，当n为0时，可通过将其末端与α-氮原子连接而形成环，或当n为1〜9的整数时为氢; R3是氢或低级烷基; R4和R5各自为氢或可被羟基或苄氧基取代的低级烷基; R6是氢或低级烷基; R7是可被低级烷氧基或芳烷基取代的烷基; R8和R9各自为氢，低级烷基或芳烷基; 和（D）和（L）各自表示构型，如果它们各自的碳原子是不对称的; 或其酸加成盐具有免疫刺激活性。

    Aqueous immunoregulatory agent
    4.
    发明授权
    Aqueous immunoregulatory agent 失效
    水性免疫调节剂

    公开(公告)号：US4191778A

    公开(公告)日：1980-03-04

    申请号：US766505

    申请日：1977-02-07

    Applicant: Yuichi Yamamura ,  Ichiro Azuma ,  Kazuhisa Sugimura ,  Hiroshi Morimoto ,  Isuke Imada ,  Masazumi Watanabe

    Inventor： Yuichi Yamamura ,  Ichiro Azuma ,  Kazuhisa Sugimura ,  Hiroshi Morimoto ,  Isuke Imada ,  Masazumi Watanabe

    IPC: A61K31/12 ,  A61K31/122 ,  A61K31/19 ,  A61K39/39 ,  A61P37/00 ,  A61P37/04

    CPC classification number: A61K31/19 ,  Y10S514/869 ,  Y10S514/87

    Abstract: The aqueous preparation such as an aqueous solution, a water-in-oil emulsion, in which a water-soluble salt of the quinonyl acid derivative of the formula: ##STR1## [wherein each R is a lower alkoxy group having 1 to 4 carbon atoms or the two R's, taken together, represent a group of --CH.dbd.CH--CH.dbd.CH--; --A--COOH means ##STR2## when both R's are lower alkoxy groups, or --(CH.sub.2).sub.n COOH (wherein n is an integer from 1 to 8) when two R's, taken together, represent a group of --CH.dbd.CH--CH.dbd.CH--] is dissolved in aqueous phase, shows an excellent immunoregulatory activity in animals including human being.

    Abstract translation: 水性制剂如水溶液，油包水乳液，其中下式的醌基酸衍生物的水溶性盐：其中每个R是具有1-4个碳原子的低级烷氧基 原子或两个R一起表示-CH = CH-CH = CH-的基团; 当两个R一起表示-CH = CH-CH的基团时，-A-COOH表示两个R均为低级烷氧基或 - （CH 2）n COOH（其中n为1至8的整数） = CH-]溶解在水相中，在包括人的动物中显示出优异的免疫调节活性。

    Printer device and printing paper for the same
    5.
    发明申请
    Printer device and printing paper for the same 审中-公开
    打印机设备和打印纸一样

    公开(公告)号：US20070285453A1

    公开(公告)日：2007-12-13

    申请号：US11717158

    申请日：2007-03-13

    Applicant: Izumi Kariya ,  Ichiro Azuma ,  Hiroshi Katsuno ,  Ryuichi Tagawa

    Inventor： Izumi Kariya ,  Ichiro Azuma ,  Hiroshi Katsuno ,  Ryuichi Tagawa

    IPC: B41J29/38

    CPC classification number: B41J29/02 ,  B41J11/46 ,  B41J29/38

    Abstract: A sublimation printer device using a cut-sheet printing paper, including: a data processing section in charge of data processing for generating printing data; a printing processing section that performs image printing to the printing paper based on the printing data provided by the data processing section; a paper feed and eject section that feeds the printing paper to the printing processing section, and ejects the printing paper through with the image printing by the printing processing section; aperture detection means for detecting an aperture formed to a margin portion of the printing paper provided to the printing processing section by the paper feed and eject section; and a control section that exercises control over the other components in terms of operation.

    Abstract translation: 一种使用片状打印纸的升华打印机装置，包括：负责生成打印数据的数据处理的数据处理部; 打印处理部，其基于由所述数据处理部提供的打印数据，向所述打印纸执行图像打印; 将打印纸馈送到打印处理部分的进纸和退出部分，并且通过打印处理部分的图像打印来弹出打印纸; 孔径检测装置，用于检测通过供纸和喷射部分形成到设置到打印处理部分的打印纸的边缘部分的孔; 以及在操作方面对其他组件进行控制的控制部分。

    Muramyldipeptide derivatives
    7.
    发明授权
    Muramyldipeptide derivatives 失效
    胞壁酰二肽衍生物

    公开(公告)号：US4606857A

    公开(公告)日：1986-08-19

    申请号：US517551

    申请日：1983-07-27

    Applicant: Akira Hasegawa ,  Ichiro Azuma ,  Yuichi Yamamura

    Inventor： Akira Hasegawa ,  Ichiro Azuma ,  Yuichi Yamamura

    IPC: A61K38/00 ,  A61K39/39 ,  A61P37/04 ,  C07H15/04 ,  C07H15/14 ,  C07K9/00

    CPC classification number: C07K9/005

    Abstract: Muramyldipeptide derivatives represented by the formula: ##STR1## wherein Ala represents alanine; Acyl represents an acyl group; R.sub.1 and R.sub.2 each represents a hydrogen atom or, when taken together, may form an alkylidene group; R.sub.3 represents a hydrogen atom, an acyl group or an alkyl group; and R.sub.4 represents a hydrogen atom or an alkyl group. These compounds have excellent immunoadjuvant activity, prophylactic and therapeutic effects against microbial infections, and antitumor activity.

    Abstract translation: 由下式表示的乳糖基二肽衍生物：其中Ala表示丙氨酸; 酰基表示酰基; R 1和R 2各自表示氢原子，或者一起可以形成亚烷基; R3表示氢原子，酰基或烷基; R4表示氢原子或烷基。 这些化合物具有优异的免疫佐剂活性，对微生物感染的预防和治疗作用以及抗肿瘤活性。

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