公开(公告)号：US06656698B1

公开(公告)日：2003-12-02

申请号：US09562480

申请日：2000-05-01

申请人： Rachel Meyers ,  Martin R. Hodge ,  Mark Williamson

发明人： Rachel Meyers ,  Martin R. Hodge ,  Mark Williamson

IPC分类号： C12Q148

CPC分类号： C12N9/1205 ,  A61K38/00 ,  A61K48/00 ,  C07K16/40 ,  C12Q1/6886 ,  C12Q2600/136

摘要： Novel human kinase-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length kinase-like proteins, the invention further provides isolated kinase-like fusion proteins, antigenic peptides, and anti-kinase-like antibodies. The invention also provides kinase-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 公开了新的人激酶样多肽，蛋白质和核酸分子。 除了分离的全长激酶样蛋白之外，本发明还提供了分离的激酶样融合蛋白，抗原肽和抗激酶样抗体。 本发明还提供激酶样核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中已经引入或破坏了类似激酶的基因的非人类转基因动物 。 还提供了利用本发明组合物的诊断，筛选和治疗方法。