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21 条记录 (耗时 0.069 秒)

    14189, a novel human kinase and uses thereof
    1.
    发明授权
    14189, a novel human kinase and uses thereof 失效
    14189，一种新的人类激酶及其用途

    公开(公告)号：US07759085B2

    公开(公告)日：2010-07-20

    申请号：US10685081

    申请日：2003-10-14

    申请人： Martin R. Hodge

    发明人： Martin R. Hodge

    IPC分类号： C12Q1/60 ,  C12N9/12

    CPC分类号： C12N9/12

    摘要： A novel human kinase protein and nucleic acid molecule is disclosed. In addition to the isolated kinase protein, the invention further provides isolated kinase fusion proteins, antigenic peptides, and anti-kinase antibodies. The invention also provides kinase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了一种新的人激酶蛋白和核酸分子。 除了分离的激酶蛋白之外，本发明还提供了分离的激酶融合蛋白，抗原肽和抗激酶抗体。 本发明还提供了激酶核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及已经导入或破坏了激酶基因的非人类转基因动物。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

    Antibodies for NF-AT interacting protein, NIP45
    3.
    发明授权
    Antibodies for NF-AT interacting protein, NIP45 失效
    NF-AT相互作用蛋白抗体，NIP45

    公开(公告)号：US06573365B1

    公开(公告)日：2003-06-03

    申请号：US09617923

    申请日：2000-07-17

    申请人： Laurie H. Glimcher ,  Martin R. Hodge

    发明人： Laurie H. Glimcher ,  Martin R. Hodge

    IPC分类号： C07K1624

    CPC分类号： C07K14/5406 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/4702 ,  C07K14/52 ,  C07K14/82 ,  C07K2319/00

    摘要： Isolated nucleic acid molecules encoding a novel protein, NIP45, that interacts with members of the Nuclear Factor of Activated T cell (NF-AT) family of proteins, are disclosed. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a NIP45 transgene. The invention further provides isolated NIP45 proteins and peptides, NIP45 fusion proteins and anti-NIP45 antibodies. Methods of using the NIP45 compositions of the invention are also disclosed, including methods for detecting NIP45 protein or mRNA in a biological sample, methods of modulating NIP45 activity in a cell, and methods for identifying agents that modulate an interaction between NIP45 and an NF-AT family protein.

    摘要翻译： 公开了编码与蛋白质的活化T细胞（NF-AT）核因子的成员相互作用的新蛋白质NIP45的分离的核酸分子。 本发明进一步提供反义核酸分子，含有本发明的核酸分子的重组表达载体，其中已导入表达载体的宿主细胞和携带NIP45转基因的非人转基因动物。 本发明进一步提供分离的NIP45蛋白和肽，NIP45融合蛋白和抗NIP45抗体。 还公开了使用本发明的NIP45组合物的方法，包括用于检测生物样品中NIP45蛋白或mRNA的方法，调节细胞中NIP45活性的方法，以及鉴定调节NIP45与NF- AT家族蛋白。

    14189, a novel human kinase and uses thereof
    4.
    发明授权
    14189, a novel human kinase and uses thereof 失效
    14189，一种新的人类激酶及其用途

    公开(公告)号：US06759221B1

    公开(公告)日：2004-07-06

    申请号：US09641690

    申请日：2000-08-18

    申请人： Martin R. Hodge

    发明人： Martin R. Hodge

    IPC分类号： C12N912

    CPC分类号： C12N9/12

    摘要： A novel human kinase protein and nucleic acid molecule is disclosed. In addition to the isolated kinase protein, the invention further provides isolated kinase fusion proteins, antigenic peptides, and anti-kinase antibodies. The invention also provides kinase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了一种新的人激酶蛋白和核酸分子。 除了分离的激酶蛋白之外，本发明还提供了分离的激酶融合蛋白，抗原肽和抗激酶抗体。 本发明还提供了激酶核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及已经导入或破坏了激酶基因的非人类转基因动物。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

    RGS-containing molecules and uses thereof
    5.
    发明授权
    RGS-containing molecules and uses thereof 失效
    含RGS的分子及其用途

    公开(公告)号：US06410240B1

    公开(公告)日：2002-06-25

    申请号：US09498959

    申请日：2000-02-04

    申请人： Martin R. Hodge ,  David Yowe

    发明人： Martin R. Hodge ,  David Yowe

    IPC分类号： C12Q168

    CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K2319/00 ,  Y02A50/411

    摘要： Novel RGS polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length RGS proteins, the invention further provides isolated RGS fusion proteins, antigenic peptides, and anti-RGS antibodies. The invention also provides RGS nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an RGS gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了新的RGS多肽，蛋白质和核酸分子。 除了分离的全长RGS蛋白之外，本发明还提供了分离的RGS融合蛋白，抗原肽和抗RGS抗体。 本发明还提供了RGS核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及RGS基因导入或破坏的非人类转基因动物。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

    14189, A NOVEL HUMAN KINASE AND USES THEREOF
    8.
    发明申请
    14189, A NOVEL HUMAN KINASE AND USES THEREOF 审中-公开
    14189，一种新的人类激素及其用途

    公开(公告)号：US20110110915A1

    公开(公告)日：2011-05-12

    申请号：US12788803

    申请日：2010-05-27

    申请人： Martin R. Hodge

    发明人： Martin R. Hodge

    IPC分类号： A61K38/45 ,  A61P37/00 ,  A61P29/00 ,  A61P7/00 ,  A61P11/00 ,  A61P1/16 ,  A61P35/02 ,  A61P11/06 ,  A61P31/18 ,  A61P37/06 ,  A61P1/04 ,  C12N9/12

    CPC分类号： C12N9/12

    摘要： A novel human kinase protein and nucleic acid molecule are disclosed. In addition to the isolated kinase protein, the invention further provides isolated kinase fusion proteins, antigenic peptides, and anti-kinase antibodies. The invention also provides kinase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了一种新的人激酶蛋白和核酸分子。 除了分离的激酶蛋白之外，本发明还提供了分离的激酶融合蛋白，抗原肽和抗激酶抗体。 本发明还提供了激酶核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中已引入或破坏了激酶基因的非人类转基因动物。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

    Kinases and uses thereof
    9.
    发明授权
    Kinases and uses thereof 失效
    激酶及其用途

    公开(公告)号：US07655432B2

    公开(公告)日：2010-02-02

    申请号：US12151520

    申请日：2008-05-07

    申请人： Martin R. Hodge

    发明人： Martin R. Hodge

    IPC分类号： C12Q1/48

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  A61K48/00 ,  C07K16/40 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

    摘要： Novel kinase polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length kinase proteins, the invention further provides isolated kinase fusion proteins, antigenic peptides, and anti-kinase antibodies. The invention also provides kinase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了新型激酶多肽，蛋白质和核酸分子。 除了分离的全长激酶蛋白之外，本发明还提供分离的激酶融合蛋白，抗原肽和抗激酶抗体。 本发明还提供了激酶核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及已经导入或破坏了激酶基因的非人类转基因动物。 还提供了利用本发明组合物的诊断，筛选和治疗方法。