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    FERRIC ORGANIC COMPOUNDS, USES THEREOF AND METHODS OF MAKING SAME
    22.
    发明申请
    FERRIC ORGANIC COMPOUNDS, USES THEREOF AND METHODS OF MAKING SAME 有权
    有机有机化合物，其用途及其制备方法

    公开(公告)号：US20150232495A1

    公开(公告)日：2015-08-20

    申请号：US14502774

    申请日：2014-09-30

    Applicant: Panion & BF Biotech, Inc.

    Inventor： David W.K. KWOK ,  Nikolay Mintchev Stoynov

    IPC: C07F15/02

    CPC classification number: C07F15/025 ,  A61K31/295 ,  C07C51/41 ,  C07C51/412 ,  C07C51/418 ,  C07C59/265 ,  C07F15/02 ,  C07C55/10 ,  C07C59/255 ,  C07C53/08 ,  C07C59/245 ,  C07C57/15

    Abstract: The present invention discloses a novel form of ferric organic compounds, including a form of ferric citrate, which are soluble over a wider range of pH, and which have a large active surface area. The ferric organic compounds of the present invention can be delivered effectively by oral route with better delivery to treat patients suffering from hyperphosphatemia, metabolic acidosis and other disorders responsive to ferric organic compound therapy.

    Abstract translation: 本发明公开了一种新型的三价铁有机化合物，其包括柠檬酸铁的形式，其可在较宽的pH范围内溶解并具有大的活性表面积。 本发明的铁有机化合物可以通过口服途径有效地递送，具有更好的输送以治疗患有高磷酸盐血症，代谢性酸中毒和对三价铁有机化合物治疗有反应的其它病症的患者。

    PHARMACEUTICAL-GRADE FERRIC ORGANIC COMPOUNDS, USES THEREOF AND METHODS OF MAKING SAME
    23.
    发明申请
    PHARMACEUTICAL-GRADE FERRIC ORGANIC COMPOUNDS, USES THEREOF AND METHODS OF MAKING SAME 有权
    药用级有机化合物，其用途及其制备方法

    公开(公告)号：US20140309298A1

    公开(公告)日：2014-10-16

    申请号：US14306756

    申请日：2014-06-17

    Applicant: Panion & BF Biotech, Inc.

    Inventor： Keith CHAN ,  Winston Town

    IPC: A61K31/295

    CPC classification number: A61K33/26 ,  A61K31/295 ,  C07C51/412 ,  C07C51/418 ,  C07C59/265 ,  C07C55/10 ,  C07C59/255 ,  C07C53/08 ,  C07C59/245 ,  C07C57/15

    Abstract: The present invention discloses a pharmaceutical-grade ferric organic compounds, including ferric citrate, which are soluble over a wider range of pH, and which have a large active surface area. A manufacturing and quality control process for making a pharmaceutical-grade ferric citrate that consistently complies with the established Manufacture Release Specification is also disclosed. The pharmaceutical-grade ferric organic compounds are suitable for treating disorders characterized by elevated serum phosphate levels.

    Abstract translation: 本发明公开了一种药物级三价铁的有机化合物，包括柠檬酸铁，其在较宽的pH范围内是可溶的，并且具有大的活性表面积。 还公开了制造和质量控制过程，用于制造符合既定制造版本规范的药用级柠檬酸铁。 药物级铁有机化合物适用于治疗以血清磷酸盐水平升高为特征的疾病。

    Test Kit For Detecting A Plurality Of Analytes
    29.
    发明申请
    Test Kit For Detecting A Plurality Of Analytes 有权

    公开(公告)号：US20210199652A1

    公开(公告)日：2021-07-01

    申请号：US17140383

    申请日：2021-01-04

    Applicant: Panion & BF Biotech Inc.

    Inventor： Chun-Liang Shih ,  Chia-Hui Liu

    IPC: G01N33/543 ,  G01N33/569

    Abstract: The present disclosure provides a test kit for simultaneously detecting a plurality of analytes, in which the test kit includes a lysis solution and a test strip. The lysis solution includes a salt, a surfactant, a stabilizer, and a buffer solution. The test strip includes a sample pad, a conjugation pad, a cellulose membrane, and a water-absorbing pad sequentially arranged on a support plate. The conjugation pad includes a conjugation pad solution and a plurality of antibody-conjugated microspheres, and the antibody-conjugated microspheres recognize plurality of analytes. The test kit of the present disclosure achieves an effect of simultaneously detecting more than or equal to four analytes even though the conjugation pad has a limited capacity of the antibody by preparing the lysis solution with appropriate ingredients and improving a formulation of the solution contained in the test strip.

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