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21.发明申请Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives 失效通过6-氰基顺式3,5-二羟基己酸衍生物制备7-氨基顺式3,5-二羟基庚酸衍生物的方法公开(公告)号：US20070142662A1
公开(公告)日：2007-06-21
申请号：US11657808
申请日：2007-01-24
Applicant: Reinhold Ohrlein , Gabriele Baisch , Hans Jurg Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
Inventor： Reinhold Ohrlein , Gabriele Baisch , Hans Jurg Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
IPC: C07C227/04
CPC classification number: C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C07C235/74 , C12P7/62 , Y02P20/55
Abstract: The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group, and Rb is a carboxy-protective group.
Abstract translation: 本发明涉及用于制备适于制备他汀类衍生物的中间体的新型合成方法，特别涉及式VI中间体的新型合成方法，其中R a a， C 1各自独立地为另一个氢或羟基保护基团，或者一起是桥接羟基保护基团，并且R b是羧基保护基团，该方法进行 通过其中R a a和R c C分别独立于另一个氢或羟基保护基的式XIX的中间体的转化，并且R b' SUB>是羧基保护基。
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22.发明授权Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives 失效通过6-氰基顺式3,5-二羟基己酸衍生物制备7-氨基顺式3,5-二羟基庚酸衍生物的方法公开(公告)号：US07199261B2
公开(公告)日：2007-04-03
申请号：US10481704
申请日：2002-07-02
Applicant: Reinhold Öhrlein , Gabriele Baisch , Hans Jürg Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
Inventor： Reinhold Öhrlein , Gabriele Baisch , Hans Jürg Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
IPC: C07C229/00
CPC classification number: C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C07C235/74 , C12P7/62 , Y02P20/55
Abstract: The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group, and Rb is a carboxy-protective group
Abstract translation: 本发明涉及用于制备适于制备他汀类衍生物的中间体的新型合成方法，特别涉及式VI中间体的新型合成方法，其中R a a， C 1各自独立地为另一个氢或羟基保护基团，或者一起是桥接羟基保护基团，并且R b是羧基保护基团，该方法进行 通过其中R a a和R c C分别独立于另一个氢或羟基保护基的式XIX的中间体的转化，并且R b' SUB>是羧基保护基
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