公开(公告)号：US20070123494A1

公开(公告)日：2007-05-31

申请号：US11558493

申请日：2006-11-10

Applicant: Irene SEIPELT ,  Eckhard Claus ,  Eckhard Guenther ,  Tilmann Schuster ,  Michael Czech ,  Emmanuel Polymeropoulos

Inventor： Irene SEIPELT ,  Eckhard Claus ,  Eckhard Guenther ,  Tilmann Schuster ,  Michael Czech ,  Emmanuel Polymeropoulos

IPC: A61K31/5415 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/501 ,  A61K31/498 ,  C07D487/02

CPC classification number: A61K45/06 ,  A61K31/4985 ,  C07D471/04

Abstract: The present invention provides new pyridopyrazine compounds which are suitable for the treatment or prevention of physiological and/or pathophysiological states mediated and/or modulated by signal transduction pathways and/or enzymes in mammals and in particular in humans.

Abstract translation: 本发明提供了适用于治疗或预防由哺乳动物，特别是人类中的信号转导途径和/或酶介导和/或调节的生理和/或病理生理状态的新的吡啶并吡嗪化合物。

公开(公告)号：US08937068B2

公开(公告)日：2015-01-20

申请号：US11558493

申请日：2006-11-10

Applicant: Irene Seipelt ,  Eckhard Claus ,  Eckhard Guenther ,  Tilmann Schuster ,  Michael Czech ,  Emmanuel Polymeropoulos

Inventor： Irene Seipelt ,  Eckhard Claus ,  Eckhard Guenther ,  Tilmann Schuster ,  Michael Czech ,  Emmanuel Polymeropoulos

IPC: A61K31/4985 ,  C07D471/04 ,  C07D519/00 ,  A61K45/06

CPC classification number: A61K45/06 ,  A61K31/4985 ,  C07D471/04

Abstract: Pyridopyrazine compounds which are suitable for the treatment or prevention of physiological and/or pathophysiological states mediated and/or modulated by signal transduction pathways and/or enzymes in mammals and in particular in humans. A compound according to the general formula (I)

Abstract translation: 吡啶并吡嗪类化合物，其适用于治疗或预防由哺乳动物，特别是人类中的信号转导途径和/或酶介导和/或调节的生理和/或病理生理状态。 根据通式（I）的化合物，

公开(公告)号：US08541462B2

公开(公告)日：2013-09-24

申请号：US13358055

申请日：2012-01-25

Applicant: Tilmann Schuster ,  Klaus Paulini ,  Peter Schmidt ,  Silke Baasner ,  Emmanuel Polymeropoulos ,  Eckhard Guenther ,  Michael Teifel

Inventor： Tilmann Schuster ,  Klaus Paulini ,  Peter Schmidt ,  Silke Baasner ,  Emmanuel Polymeropoulos ,  Eckhard Guenther ,  Michael Teifel

IPC: A61K31/403 ,  C07D209/82

CPC classification number: C07K5/06191 ,  A61K38/00 ,  C07K5/0827

Abstract: The present invention provides novel tetrahydrocarbazole compounds according to formula (I) as ligands of G-protein coupled receptors (GPCR) which are useful in the treatment and/or prophylaxis of physiological and/or pathological conditions in mammals mediated by GPCR or of physiological and/or pathological conditions which can be treated by modulation of these receptors.

Abstract translation: 本发明提供了根据式（I）的新型四氢咔唑化合物作为G蛋白偶联受体（GPCR）的配体，其可用于治疗和/或预防由GPCR介导的哺乳动物的生理和/或病理状况或生理和/ /或可以通过调节这些受体来治疗的病理状况。

公开(公告)号：US20120259151A1

公开(公告)日：2012-10-11

申请号：US13439107

申请日：2012-04-04

Applicant: Matthias GERLACH ,  Irene Seipelt ,  Lars Blumenstein ,  Gilbert Mueller ,  Eckhard Guenther ,  Tilmann Schuster ,  Michael Teifel

Inventor： Matthias GERLACH ,  Irene Seipelt ,  Lars Blumenstein ,  Gilbert Mueller ,  Eckhard Guenther ,  Tilmann Schuster ,  Michael Teifel

IPC: A61N5/00 ,  A61K31/4985 ,  A61K31/501 ,  C07F9/6561 ,  A61K31/675 ,  A61K31/5377 ,  C07F7/10 ,  A61K31/695 ,  C07H15/26 ,  A61K31/706 ,  A61K39/395 ,  A61K33/24 ,  A61K38/50 ,  A61K38/14 ,  A61K38/21 ,  A61K31/704 ,  A61K31/7048 ,  A61P35/00 ,  A61P29/00 ,  A61P37/00 ,  A61P19/02 ,  A61P31/18 ,  A61P25/28 ,  A61P17/06 ,  A61P17/02 ,  A61P35/02 ,  A61P3/10 ,  A61P13/12 ,  A61P37/06 ,  A61P1/00 ,  A61P9/10 ,  A61P9/04 ,  A61P9/00 ,  A61P11/02 ,  A61P3/04 ,  A61P7/02 ,  A61P9/12 ,  A61P11/06 ,  A61P37/08 ,  A61P21/00 ,  A61P3/08 ,  A61P9/08 ,  A61P11/00 ,  A61P25/00 ,  A61P15/00 ,  A61P3/00 ,  C07D471/04

CPC classification number: A61K31/4985 ,  A61K31/501 ,  A61K31/5377 ,  C07D471/04

Abstract: The present invention provides new pyridopyrazine compounds which are suitable for the treatment or prevention of physiological and/or pathophysiological states mediated and/or modulated by signal transduction pathways and/or enzymes in mammals and in particular in humans.

公开(公告)号：US20120214768A1

公开(公告)日：2012-08-23

申请号：US13455435

申请日：2012-04-25

Applicant: Matthias Gerlach ,  Irene Seipelt ,  Eckhard Guenther ,  Emmanuel Polymeropoulos ,  Tilmann Schuster ,  Eckhard Claus

Inventor： Matthias Gerlach ,  Irene Seipelt ,  Eckhard Guenther ,  Emmanuel Polymeropoulos ,  Tilmann Schuster ,  Eckhard Claus

IPC: A61K31/4985 ,  C07F9/6561 ,  A61K31/675 ,  A61K31/538 ,  A61P1/16 ,  A61K31/551 ,  A61P35/00 ,  A61P17/06 ,  A61P9/10 ,  C07D471/04 ,  A61K31/541

CPC classification number: C07D471/04

Abstract: The invention relates to pyrido[2,3-b]pyrazine compounds of general formulae (Ia) and (Ib), to their preparation and use, for example, for the treatment of malignant disorders and other disorders based on pathological cell proliferations.

公开(公告)号：US20120209050A1

公开(公告)日：2012-08-16

申请号：US13455187

申请日：2012-04-25

Applicant: Matthias GERLACH ,  Irene Seipelt ,  Eckhard Guenther ,  Emmanuel Polymeropoulos ,  Tilmann Schuster ,  Eckhard Claus

Inventor： Matthias GERLACH ,  Irene Seipelt ,  Eckhard Guenther ,  Emmanuel Polymeropoulos ,  Tilmann Schuster ,  Eckhard Claus

IPC: A61K31/4985 ,  A61P37/00 ,  A61P29/00 ,  A61P19/02 ,  A61P25/28 ,  A61P31/18 ,  A61P17/06 ,  A61P17/02 ,  A61P37/04 ,  A61P3/10 ,  A61P35/02 ,  A61P13/12 ,  A61P27/14 ,  A61P9/10 ,  A61P11/02 ,  A61P9/00 ,  A61P37/06 ,  A61P9/04 ,  A61P1/00 ,  A61P25/00 ,  A61P7/02 ,  A61P21/00 ,  A61P3/08 ,  A61P3/04 ,  A61P11/04 ,  A61P11/00 ,  A61P3/00 ,  A61P9/12 ,  A61N5/06 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: The invention relates to pyrido[2,3-b]pyrazine compounds of general formulae (Ia) and (Ib), to their preparation and use, for example, for the treatment of malignant disorders and other disorders based on pathological cell proliferations.

Abstract translation: 本发明涉及通式（Ia）和（Ib）的吡啶并[2,3-b]吡嗪化合物及其制备和用途，例如用于治疗基于病理细胞增殖的恶性病症和其它病症。

公开(公告)号：US20100266538A1

公开(公告)日：2010-10-21

申请号：US12731243

申请日：2010-03-25

Applicant: Matthias Gerlach ,  Irene Seipelt ,  Eckhard Guenther ,  Tilmann Schuster ,  Emmanuel Polymeropoulos ,  Michael Czech ,  Eckhard Claus

Inventor： Matthias Gerlach ,  Irene Seipelt ,  Eckhard Guenther ,  Tilmann Schuster ,  Emmanuel Polymeropoulos ,  Michael Czech ,  Eckhard Claus

IPC: A61K38/21 ,  C07D241/44 ,  A61K31/498 ,  A61K38/46 ,  A61K38/14 ,  A61K33/24 ,  A61K31/573 ,  A61P35/00 ,  A61P35/04

CPC classification number: C07D241/44 ,  C07D401/12 ,  C07D403/04 ,  C07D409/12 ,  C07D413/12

Abstract: The invention provides quinoxalines of the general formula I which are used as medicaments preferably for treating tumour disorders, in particular in cases of drug resistance to other active compounds and in cases of metastasic carcinoma. The possible applications are not limited to tumour disorders.

Abstract translation: 本发明提供了通式I的喹喔啉，其用作优选用于治疗肿瘤病症的药物，特别是在对其它活性化合物的耐药性和转移性癌症的情况下。 可能的应用不限于肿瘤病症。

公开(公告)号：US07205299B2

公开(公告)日：2007-04-17

申请号：US10858751

申请日：2004-06-02

Applicant: Matthias Gerlach ,  Tilmann Schuster ,  Peter Ernig ,  Peter Schmidt ,  Silke Baasner ,  Eckhard Günther

Inventor： Matthias Gerlach ,  Tilmann Schuster ,  Peter Ernig ,  Peter Schmidt ,  Silke Baasner ,  Eckhard Günther

IPC: A61K31/5025 ,  A61K31/4709 ,  A61K31/4427 ,  C07D487/02 ,  C07D215/38

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D471/04

Abstract: The invention relates to indole derivatives which are used as drugs for treating tumor diseases, in particular when there is drug resistance against other active compounds and where there is a metastasizing carcinoma.

Abstract translation: 本发明涉及用作治疗肿瘤疾病的药物的吲哚衍生物，特别是当存在耐其他活性化合物的耐药性以及存在转移性癌时。

公开(公告)号：US20050020636A1

公开(公告)日：2005-01-27

申请号：US10892040

申请日：2004-07-15

Applicant: Matthias Gerlach ,  Tilmann Schuster ,  Peter Schmidt ,  Silke Baasner ,  Eckhard Gunther

Inventor： Matthias Gerlach ,  Tilmann Schuster ,  Peter Schmidt ,  Silke Baasner ,  Eckhard Gunther

IPC: A61K31/405 ,  A61K31/4439 ,  C07D401/12 ,  C07

CPC classification number: C07D401/12 ,  C04B35/632

Abstract: The invention relates to novel N-substituted indolyl-3-glyoxylamides of the general formula I, their preparation and use as medicaments, in particular for the treatment of tumors.

Abstract translation: 本发明涉及通式I的新型N-取代的吲哚基-3-乙醛酰胺，其制备和用作药物，特别是用于治疗肿瘤。