公开(公告)号：US11154423B2

公开(公告)日：2021-10-26

申请号：US16511500

申请日：2019-07-15

Applicant: Avedro, Inc.

Inventor： Marc D. Friedman ,  Pavel Kamaev ,  Mikhail Smirnov

IPC: A61N5/06 ,  A61F9/007 ,  A61F9/008

Abstract: A system for corneal treatment includes a light source that activates cross-linking in at least one selected region of a cornea treated with a cross-linking agent. The light source delivers photoactivating light to the at least one selected region of the cornea according to a set of parameters. The system includes a controller that receives input relating to the cross-linking agent and the set of parameters. The controller includes computer-readable storage media storing: (A) program instructions for determining cross-linking resulting from reactions involving ROS including at least peroxides, superoxides, and hydroxyl radicals, and (B) program instructions for determining cross-linking from reactions not involving oxygen. The controller executes the program instructions to output a calculated amount of cross-linking in the at least one selected region of the cornea. In response to the calculated amount of cross-linking, the light source adjusts at least one value in the set of parameters.

公开(公告)号：US20190336336A1

公开(公告)日：2019-11-07

申请号：US16511500

申请日：2019-07-15

Applicant: Avedro, Inc.

Inventor： Marc D. Friedman ,  Pavel Kamaev ,  Mikhail Smirnov

IPC: A61F9/007 ,  A61F9/008

Abstract: A system for corneal treatment includes a light source that activates cross-linking in at least one selected region of a cornea treated with a cross-linking agent. The light source delivers photoactivating light to the at least one selected region of the cornea according to a set of parameters. The system includes a controller that receives input relating to the cross-linking agent and the set of parameters. The controller includes computer-readable storage media storing: (A) program instructions for determining cross-linking resulting from reactions involving ROS including at least peroxides, superoxides, and hydroxyl radicals, and (B) program instructions for determining cross-linking from reactions not involving oxygen. The controller executes the program instructions to output a calculated amount of cross-linking in the at least one selected region of the cornea. In response to the calculated amount of cross-linking, the light source adjusts at least one value in the set of parameters.

公开(公告)号：US20160310758A1

公开(公告)日：2016-10-27

申请号：US15137748

申请日：2016-04-25

Applicant: Avedro, Inc.

Inventor： Marc D. Friedman ,  Mikhail Smirnov ,  Pavel Kamaev

IPC: A61N5/06 ,  A61F9/00 ,  A61M35/00

CPC classification number: A61N5/0624 ,  A61F9/0079 ,  A61F9/029 ,  A61M2202/0208 ,  A61M2205/3368 ,  A61M2205/36 ,  A61M2205/52 ,  A61M2210/0612 ,  A61N5/062 ,  A61N2005/0626 ,  A61N2005/0648 ,  A61N2005/0661

Abstract: An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.

Abstract translation: 抗微生物治疗系统包括可佩戴的光活化装置。 可穿戴光激活装置包括被配置为被放置在被摄体的头部上的主体的主体的一个或多个眼睛上。 身体包括允许一只或多只眼睛透过身体观察的一个或多个窗户或开口。 身体包括耦合到身体并被配置为根据照明参数将光激活光引导到一个或多个眼睛的一个或多个光活化光源。 照明参数确定光活化光的剂量，其根据光化学动力学反应激活施加到一个或多个眼睛上的光敏剂，并产生在一个或多个眼睛中提供抗微生物作用的活性氧，而基本上不诱导交联， 在一个或多个眼睛中产生生物力学变化的连接活动。