公开(公告)号：US12121746B2

公开(公告)日：2024-10-22

申请号：US17433890

申请日：2020-01-30

申请人： IMMUNOLIGHT, LLC

发明人： Frederic A. Bourke, Jr. ,  Harold Walder ,  Zakaryae Fathi ,  Wayne F. Beyer ,  Ronald A. Rudder ,  Joseph H. Simmons

IPC分类号： A61N5/06 ,  A61K35/12 ,  A61K41/00 ,  A61N5/067 ,  C09J133/08 ,  C09K11/02 ,  C09K11/59 ,  C09K11/76 ,  C09K11/77 ,  C12N15/01 ,  F21K2/00 ,  F21S11/00 ,  F21V9/40 ,  H01J45/00 ,  H01L23/00 ,  H01L31/0352 ,  H01L31/054 ,  H01L31/06 ,  H01L31/055

CPC分类号： A61N5/0625 ,  A61K35/12 ,  A61K41/00 ,  A61K41/0057 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/067 ,  C09J133/08 ,  C09K11/025 ,  C09K11/595 ,  C09K11/76 ,  C09K11/7701 ,  C09K11/7792 ,  C12N15/01 ,  F21K2/00 ,  F21S11/007 ,  F21V9/40 ,  H01J45/00 ,  H01L24/29 ,  H01L24/83 ,  H01L31/035281 ,  H01L31/054 ,  H01L31/06 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/0663 ,  H01L31/055 ,  H01L2224/2919 ,  H01L2224/29393 ,  H01L2224/8322 ,  H01L2224/83855

摘要： An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, particularly medical uses for treatment of cell proliferation disorders.

公开(公告)号：US20240325777A1

公开(公告)日：2024-10-03

申请号：US18705350

申请日：2022-10-26

申请人： David PON

发明人： David PON

IPC分类号： A61N5/06 ,  A61N5/067

CPC分类号： A61N5/062 ,  A61N5/067 ,  A61N2005/0627 ,  A61N2005/0642 ,  A61N2005/0651 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/0663

摘要： A process that provides preventative, protective and therapeutic treatment for non-ocular biological tissues or fluids includes applying a pulsed energy source to an ocular tissue or a target fluid to therapeutically or prophylactically treat the non-ocular tissue or fluid. A pulsed energy source having selected energy parameters may be applied to one or more ocular blood vessel of an individual who has a non-ocular disease/disorder. In accordance with one aspect of the present disclosure, it is determined that an individual has one or more non-ocular disease/disorder or other degenerative disease or is at a risk of developing such a disease, and pulsed electromagnetic energy is applied to an ocular tissue of the individual to therapeutically or prophylactically treat the non-ocular disease/disorder.

公开(公告)号：US12083355B1

公开(公告)日：2024-09-10

申请号：US18400131

申请日：2023-12-29

申请人： Sichuan Cancer Hospital

发明人： Meihua Chen ,  Pingjin Zou ,  Xinyu Xue ,  Jinyi Lang ,  Lili Xing ,  Rui Lin

IPC分类号： A61N5/06 ,  A61K41/00 ,  C12N5/09 ,  C12N13/00 ,  G01N33/50 ,  H05B45/30

CPC分类号： A61N5/062 ,  A61K41/0071 ,  C12N5/0693 ,  C12N13/00 ,  G01N33/5091 ,  H05B45/30 ,  A61N2005/0652

摘要： A photodynamic therapy tablet and corresponding preparation method, as well as a construction method and system specifically designed for anti-tumor models, are disclosed. The tablet includes a wireless power supply unit, a circuit unit, micrometer-level LED array, and a flexible transparent biocompatible encapsulation. It can be surgically implanted in close proximity to tumor cells within the human body, enabling precise irradiation of the targeted tumor cells. By harnessing light of a specific wavelength, the tablet facilitates the generation of lipid peroxides, which, in conjunction with a ferroptosis inducer, effectively triggers ferroptotic cell death in tumor cells. The ultrasound wireless self-powering photodynamic therapy tablet is utilized for the treatment of tumor cells through photodynamic therapy (PDT). By combining the ferroptosis inducer with PDT, the present invention effectively addresses the issue of limited efficacy observed when using the ferroptosis inducer alone.

公开(公告)号：US12083354B2

公开(公告)日：2024-09-10

申请号：US17495297

申请日：2021-10-06

申请人： SHIMADZU CORPORATION

发明人： Akihiro Ishikawa

IPC分类号： A61N5/06 ,  A61N5/067

CPC分类号： A61N5/062 ,  A61N5/067 ,  A61N2005/0652 ,  A61N2005/0662

摘要： A treatment support device is provided with an irradiation unit, a fluorescence detection unit, and a change acquisition unit for acquiring a change degree of a fluorescence signal detected within a first time range within a treatment time. The treatment support device is provided with: a determination unit for determining whether or not the progress of the treatment is in a steady state based on the fact that the change degree of the fluorescence signal within the first time range falls within a predetermined range of the change degree; and an operation control unit for performing predetermined operation control when the progress of the treatment is determined to be in the steady state by the determination unit.

公开(公告)号：US12083177B2

公开(公告)日：2024-09-10

申请号：US17557205

申请日：2021-12-21

申请人： FLE INTERNATIONAL S.R.L.

发明人： Remigio Piergallini ,  Nikolaos Loupis ,  David Ohayon ,  Kevin Wilkinson ,  Giovanni Scapagnini

IPC分类号： A61K41/00 ,  A61K9/00 ,  A61K31/365 ,  A61N5/06 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10

CPC分类号： A61K41/00 ,  A61K9/0014 ,  A61K31/365 ,  A61N5/06 ,  A61N5/0624 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  A61N5/062 ,  A61N2005/0661

摘要： The present document describes methods of using compositions for inhibiting biofilm formation, or disrupting existing or developing biofilms in a subject, which composition comprises at least one chromophore and a pharmacologically acceptable carrier.

公开(公告)号：US12076197B2

公开(公告)日：2024-09-03

申请号：US17115446

申请日：2020-12-08

申请人： Rejuvatek Medical Inc.

发明人： Timothy N. Turner ,  Jack H. Savage ,  Jazz J. L. Wilkey ,  Julie Gramyk ,  Jillian Marty

IPC分类号： A61B90/00 ,  A61B17/00 ,  A61F7/00 ,  A61N5/06 ,  A61N5/10 ,  A61N7/00

CPC分类号： A61B90/39 ,  A61B17/00 ,  A61F7/00 ,  A61B2017/00769 ,  A61B2090/395 ,  A61N5/062 ,  A61N5/10 ,  A61N7/00

摘要： Embodiments of a method for removing a tattoo through patterned trans-epidermal pigment release includes determining first treatment area of skin of a patient through a primary template including primary apertures, marking the first treatment area of skin of the patient along borders of the primary apertures to outline a grid of primary tegulae, and delivering a tattoo removal fluid to the marked first exposed skin. In an alternate embodiment, a template, which may be adhered to the skin, is used during a disruption process to create a structured, patterned procedure to remove skin irregularities. The template has a plurality of needle apertures, an adhesive layer, and a release liner. The release liner may be removed, exposing the adhesive layer, so that the template, with the plurality of needle apertures, may be positioned over the skin irregularity.

公开(公告)号：US20240269286A1

公开(公告)日：2024-08-15

申请号：US18454275

申请日：2023-08-23

申请人： EOS Neuroscience, Inc.

发明人： Alan Horsager ,  Kenneth Greenberg ,  Benjamin C. Matteo ,  Edward S. Boyden ,  Douglas G. Ririe ,  James C. Eisenach ,  Christian Wentz

IPC分类号： A61K41/00 ,  A61K31/7088 ,  A61N5/06 ,  C07K14/195 ,  C07K14/215 ,  C07K14/37

CPC分类号： A61K41/00 ,  A61K31/7088 ,  A61N5/062 ,  C07K14/195 ,  C07K14/215 ,  C07K14/37 ,  C07K2319/60 ,  C12N2750/14143 ,  C12N2810/6027

摘要： Provided are compositions and methods for the selective silencing of neurons in pain pathway by using a combination of inhibitory light-sensitive protein gene transfer and wavelength specific illumination.

公开(公告)号：US12059385B2

公开(公告)日：2024-08-13

申请号：US16932772

申请日：2020-07-19

申请人： Ismail Mohammed Yousif Musallam

发明人： Ismail Mohammed Yousif Musallam

IPC分类号： A61H5/00 ,  A61H21/00 ,  A61H23/00 ,  A61K9/00 ,  A61K31/375 ,  A61K35/16 ,  A61K35/19 ,  A61K38/17 ,  A61N1/04 ,  A61N1/05 ,  A61N1/36 ,  A61N5/06 ,  A61N7/00 ,  A61P27/02

CPC分类号： A61H5/00 ,  A61H21/00 ,  A61H23/006 ,  A61K9/0048 ,  A61K31/375 ,  A61K35/16 ,  A61K35/19 ,  A61K38/17 ,  A61N1/0456 ,  A61N1/36014 ,  A61N1/36034 ,  A61N1/36046 ,  A61N1/36053 ,  A61N5/062 ,  A61N5/0622 ,  A61N7/00 ,  A61P27/02 ,  A61H2201/105 ,  A61N1/0546 ,  A61N2005/0663 ,  A61N2007/0026 ,  A61N2007/0043

摘要： A method and/or device for treatment of dysregulated reduced blood (e.g., reduced ocular blood flow) and, more particularly, but not exclusively, to methods and/or devices for treatment retinal, choroidal and optic nerve disorders. The treatment includes application of an effective amount of ONS ophthalmic nerve stimulation alone and/or in combination with peri-ocular administration of substance Neuropeptides/Platelet Rich Plasma (N/PRP) and/or ascorbic acid as a sympatholytic agent.

公开(公告)号：US20240261589A1

公开(公告)日：2024-08-08

申请号：US18565568

申请日：2023-03-16

申请人： TOHOKU UNIVERSITY

发明人： Yoshio YAHATA ,  Masahiro SAITO ,  Hitoshi SOYAMA

IPC分类号： A61N5/06 ,  A61C5/50 ,  A61N5/067

CPC分类号： A61N5/062 ,  A61C5/50 ,  A61N5/067 ,  A61N2005/0644

摘要： A liquid drug delivery device 5 for delivering a liquid drug to a target site 2a in a living tissue 2 by irradiating the liquid drug with laser light L at a location 1a near the target site 2a.

公开(公告)号：US20240261023A1

公开(公告)日：2024-08-08

申请号：US18563823

申请日：2022-03-25

申请人： Universite de Bordeaux ,  INSERM (Institut National de la Santé et de la Recherche Medicale) ,  Fondation Bordeaux Universite

发明人： Bruno Quesson

IPC分类号： A61B18/22 ,  A61B5/01 ,  A61B5/055 ,  A61B18/00 ,  A61B18/20 ,  A61N5/00 ,  A61N5/06 ,  A61N5/067 ,  G01K11/32

CPC分类号： A61B18/22 ,  A61B5/015 ,  A61B5/055 ,  A61N5/062 ,  A61N5/067 ,  G01K11/32 ,  A61B2018/00023 ,  A61B2018/00351 ,  A61B2018/00702 ,  A61B2018/00714 ,  A61B2018/00791 ,  A61B2018/2065 ,  A61B2018/2211 ,  A61N2005/005 ,  A61N2005/0626 ,  A61N2005/063

摘要： A laser device for treating a target region of biological tissue comprises: a sheath; at least two optical fibers in the sheath, each configured to guide a laser beam to the target region, distal ends of at least two of the optical fibers configured so that each emits a laser beam in a different direction; a system of laser sources configured to generate at least two laser beams, the two laser beams having different or identical wavelengths with adjustable power; and a laser-beam control unit configured to control the system of laser sources so as to select the wavelength, the power, the duration of the deposition of laser energy, and the moment of emission of each of the laser beams in the direction of the target region so as to dynamically generate and adjust a 3D thermal distribution having a geometric shape matching a geometric shape of the target region.