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31 条记录 (耗时 0.038 秒)

    Exendins and Exendin Agonist Analogs to Regulate Gastrointestinal Motility
    21.
    发明申请
    Exendins and Exendin Agonist Analogs to Regulate Gastrointestinal Motility 有权
    Exendins和Exendin激动剂类似物调节胃肠蠕动

    公开(公告)号：US20090163423A1

    公开(公告)日：2009-06-25

    申请号：US12353861

    申请日：2009-01-14

    申请人： Andrew A. Young ,  Bronislava Gedulin

    发明人： Andrew A. Young ,  Bronislava Gedulin

    IPC分类号： A61K38/17

    CPC分类号： C07K14/605 ,  A61K38/00 ,  A61K38/22 ,  A61K38/26 ,  C07K14/57563 ,  A61K2300/00

    摘要： Methods for reducing gastric motility and delaying gastric emptying for therapeutic and diagnostic purposes are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist. Methods for treating conditions associated with elevated, inappropriate, or undesired post-prandial blood glucose levels are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist alone or in conjunction with other anti-gastric emptying agents.

    摘要翻译： 公开了减少胃动力和延迟胃排空用于治疗和诊断目的的方法，其包括施用有效量的毒蜥外泌肽或毒蜥外泌肽激动剂。 公开了治疗与升高的，不适当的或不期望的餐后血糖水平相关的病症的方法，其包括单独施用有效量的毒蜥外泌肽或毒蜥外泌肽激素，或与其他抗胃排空剂联合施用。

    Exendin pharmaceutical compositions
    22.
    发明授权
    Exendin pharmaceutical compositions 有权
    毒蜥外泌肽药物组合物

    公开(公告)号：US07521423B2

    公开(公告)日：2009-04-21

    申请号：US10896244

    申请日：2004-07-20

    申请人： Andrew A. Young ,  Bronislava Gedulin

    发明人： Andrew A. Young ,  Bronislava Gedulin

    IPC分类号： A61K38/00 ,  C07K5/00

    CPC分类号： C07K14/605 ,  A61K38/00 ,  A61K38/22 ,  A61K38/26 ,  C07K14/57563 ,  A61K2300/00

    摘要： Methods for reducing gastric motility and delaying gastric emptying for therapeutic and diagnostic purposes are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist. Methods for treating conditions associated with elevated, inappropriate, or undesired post-prandial blood glucose levels are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist alone or in conjunction with other anti-gastric emptying agents.

    摘要翻译： 公开了减少胃动力和延迟胃排空用于治疗和诊断目的的方法，其包括施用有效量的毒蜥外泌肽或毒蜥外泌肽激动剂。 公开了治疗与升高的，不适当的或不期望的餐后血糖水平相关的病症的方法，其包括单独施用有效量的毒蜥外泌肽或毒蜥外泌肽激素，或与其他抗胃排空剂联合施用。

    Methods for glucagon suppression using modified exendins
    23.
    发明授权
    Methods for glucagon suppression using modified exendins 有权
    使用改良的毒蜥外泌肽抑制胰高血糖素的方法

    公开(公告)号：US07407932B2

    公开(公告)日：2008-08-05

    申请号：US11584114

    申请日：2006-10-19

    申请人： Andrew A. Young ,  Bronislava Gedulin

    发明人： Andrew A. Young ,  Bronislava Gedulin

    IPC分类号： A61K38/22 ,  A61K38/00

    CPC分类号： C07K14/57563 ,  A61K38/00 ,  A61K47/60

    摘要： Methods for use of an exendin, an exendin agonist, or a modified exendin or exendin agonist having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, for lowering glucagon levels and/or suppressing glucagon secretion in a subject are provided. These methods are useful in treating hyperglucagonemia and other conditions that would be benefited by lowering plasma glucgon or suppressing glucagon secretion.

    摘要翻译： 使用与一种或多种聚乙二醇聚合物连接的毒蜥外泌肽或毒蜥外泌激素，例如降低胰高血糖素水平和/或抑制受试者中胰高血糖素分泌的毒蜥外泌肽，毒蜥外泌肽激动剂或经修饰的毒蜥外泌肽或毒蜥外泌肽激素的方法是： 提供。 这些方法可用于治疗通过降低血浆胰高血糖素或抑制胰高血糖素分泌而受益的高胰高血糖素血症和其它病症。

    Method for treating or preventing gastritis using amylin or amylin agonists
    24.
    发明授权
    Method for treating or preventing gastritis using amylin or amylin agonists 失效
    使用胰岛淀粉样多肽或胰岛淀粉样多肽激动剂治疗或预防胃炎的方法

    公开(公告)号：US07101853B2

    公开(公告)日：2006-09-05

    申请号：US08851965

    申请日：1997-05-06

    申请人： Andrew A. Young ,  Bronislava Gedulin ,  Gareth Wyn Beynon

    发明人： Andrew A. Young ,  Bronislava Gedulin ,  Gareth Wyn Beynon

    IPC分类号： A61K38/00

    CPC分类号： A61K38/22

    摘要： Methods for treating or preventing gastritis or gastric injury are disclosed, comprising administering a therapeutically effective amount of an amylin or an amylin agonist. Methods are also disclosed for the treatment of pain, fever, inflammation, arthritis, hypercoagulability, or other conditions for which a non-steroidal anti-inflammatory drug would be indicated, comprising administering an amylin or amylin agonist in conjunction with administering a therapeutically effective amount of a non-steroidal anti-inflammatory agent. Pharmaceutical compositions comprising an amylin or amylin agonist and a non-steroidal anti-inflammatory drug are also disclosed.

    摘要翻译： 公开了治疗或预防胃炎或胃损伤的方法，包括施用治疗有效量的胰岛淀粉样多肽或胰岛淀粉样多肽激动剂。 还公开了用于治疗疼痛，发烧，炎症，关节炎，高凝状态或其中将表示非甾体抗炎药物的其它条件的方法，包括施用胰岛淀粉样多肽或胰岛淀粉样多肽激动剂，连同给予治疗有效量 的非甾体抗炎剂。 还公开了包含胰岛淀粉样多肽或胰岛淀粉样多肽激动剂和非甾体抗炎药物的药物组合物。

    Exendins and exendin agonists for weight reduction and obesity
    30.
    发明授权
    Exendins and exendin agonists for weight reduction and obesity 有权
    毒蜥外泌肽和毒蜥外泌激素用于减轻体重和肥胖

    公开(公告)号：US07741269B2

    公开(公告)日：2010-06-22

    申请号：US10895909

    申请日：2004-07-20

    申请人： Andrew A. Young ,  Sunil Bhavsar ,  Bronislava Gedulin

    发明人： Andrew A. Young ,  Sunil Bhavsar ,  Bronislava Gedulin

    IPC分类号： A61K38/28 ,  A61K38/38 ,  A61K38/00

    CPC分类号： A61K9/0019 ,  A61K38/00 ,  A61K38/22 ,  A61K38/2207 ,  A61K38/2264 ,  A61K38/23 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26 ,  A61K47/44 ,  C07K14/57563 ,  Y10S514/866 ,  A61K2300/00

    摘要： Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.

    摘要翻译： 公开了通过减少食物摄入可以缓解的病症或病症的方法，其包括单独施用有效量的毒蜥外泌肽或毒蜥外泌肽激素，或与影响饱腹感的其它化合物或组合物联合施用。 该方法可用于治疗条件或障碍，包括肥胖，II型糖尿病，进食障碍和胰岛素抵抗综合征。 该方法对于降低血浆葡萄糖水平，降低血浆脂质水平，降低心脏风险，降低食欲和降低受试者的体重也是有用的。 还公开了用于本发明方法的药物组合物。