公开(公告)号：US20240350636A1

公开(公告)日：2024-10-24

申请号：US18757097

申请日：2024-06-27

申请人： AIM Targeted Therapies, Inc.

发明人： Glenn ABRAHMSOHN

IPC分类号： A61K47/02 ,  A61K8/19 ,  A61K8/20 ,  A61K8/22 ,  A61K8/40 ,  A61K8/43 ,  A61K8/46 ,  A61K8/49 ,  A61K8/86 ,  A61K9/00 ,  A61K9/06 ,  A61K31/155 ,  A61K31/18 ,  A61K33/40 ,  A61K47/16 ,  A61K47/26 ,  A61K47/32 ,  A61K47/42 ,  A61L15/18 ,  A61L15/20 ,  A61L15/44 ,  A61L29/08 ,  A61L29/10 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16 ,  A61Q11/00 ,  A61Q17/00

CPC分类号： A61K47/02 ,  A61K8/19 ,  A61K8/20 ,  A61K8/22 ,  A61K8/40 ,  A61K8/43 ,  A61K8/466 ,  A61K8/498 ,  A61K8/86 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/06 ,  A61K31/155 ,  A61K31/18 ,  A61K33/40 ,  A61K47/16 ,  A61K47/26 ,  A61K47/32 ,  A61K47/42 ,  A61L15/18 ,  A61L15/20 ,  A61L15/44 ,  A61L29/08 ,  A61L29/106 ,  A61L29/16 ,  A61L31/08 ,  A61L31/088 ,  A61L31/16 ,  A61Q11/00 ,  A61Q17/005 ,  A61L2300/202 ,  A61L2300/206 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2420/00

摘要： Therapeutic compositions, primarily for topical application, and methods of making and using the composition. Pharmaceutical compositions formulated for specific forms of administration are also provided.

公开(公告)号：US12115179B2

公开(公告)日：2024-10-15

申请号：US18320462

申请日：2023-05-19

申请人： Boehringer Ingelheim International GmbH

发明人： Peter Eickelmann ,  Michael Mark ,  Leo John Seman ,  Leo Thomas ,  Uli Christian Broedl ,  Rolf Grempler

IPC分类号： A61K31/7048 ,  A61K31/00 ,  A61K31/155 ,  A61K31/198 ,  A61K31/341 ,  A61K31/351 ,  A61K31/39 ,  A61K31/403 ,  A61K31/4439 ,  A61K31/522 ,  A61K31/70 ,  A61K31/7004 ,  A61K31/7008 ,  A61K45/06

CPC分类号： A61K31/7048 ,  A61K31/00 ,  A61K31/155 ,  A61K31/198 ,  A61K31/341 ,  A61K31/351 ,  A61K31/39 ,  A61K31/403 ,  A61K31/4439 ,  A61K31/522 ,  A61K31/70 ,  A61K31/7004 ,  A61K31/7008 ,  A61K45/06 ,  A61K31/00 ,  A61K2300/00 ,  A61K31/155 ,  A61K2300/00 ,  A61K31/198 ,  A61K2300/00 ,  A61K31/341 ,  A61K2300/00 ,  A61K31/351 ,  A61K2300/00 ,  A61K31/39 ,  A61K2300/00 ,  A61K31/403 ,  A61K2300/00 ,  A61K31/4439 ,  A61K2300/00 ,  A61K31/70 ,  A61K2300/00 ,  A61K31/7004 ,  A61K2300/00 ,  A61K31/7008 ,  A61K2300/00

摘要： The invention relates to a pharmaceutical composition comprising an SGLT2 inhibitor, a DPPIV inhibitor and a third antidiabetic agent which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.

公开(公告)号：US12109180B2

公开(公告)日：2024-10-08

申请号：US17660515

申请日：2022-04-25

申请人： Avery Dennison Corporation

发明人： Anna Andrews ,  Rachel Shi ,  Anne Marie Wibaux ,  Emily Berlin

IPC分类号： A61K31/155 ,  A61K9/70

CPC分类号： A61K31/155 ,  A61K9/7007 ,  A61K9/7084

摘要： Compositions and methods to produce adhesive articles with active agents concentrated at the substrate contacting surface. The active agents are applied in powder form, or in combination with a liquid or gel vehicle, to the substrate contacting surface of an adhesive layer of an adhesive article. The active agent compositions are directly applied to the adhesive layer, or are first applied to a release liner, which is then brought into contact with the adhesive layer to dispose the active agent compositions to the substrate contacting surface of the adhesive layer. Upon application of the adhesive article to a substrate, the active agent is delivered to a region of interest on the substrate.

公开(公告)号：US20240299357A1

公开(公告)日：2024-09-12

申请号：US18610100

申请日：2024-03-19

申请人： HUA Medicine (Shanghai) Ltd.

发明人： Li Chen ,  Yongguo Li ,  Gaosen Wang ,  Huisheng Gao

IPC分类号： A61K31/4155 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K31/155 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/522 ,  A61K31/7034 ,  A61K45/06 ,  A61K47/38 ,  A61P3/10 ,  C07D231/38 ,  C07D403/12

CPC分类号： A61K31/4155 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1694 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2086 ,  A61K9/2095 ,  A61K9/2813 ,  A61K9/284 ,  A61K9/2866 ,  A61K31/155 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/522 ,  A61K31/7034 ,  A61K45/06 ,  A61K47/38 ,  A61P3/10 ,  C07D231/38 ,  C07D403/12

摘要： Disclosed is a pharmaceutical combination comprising a glucokinase activator or a pharmaceutically acceptable salt thereof, an isotopic label thereof, a crystalline form thereof, a hydrate, a solvate, a diastereomeric or enantiomeric form thereof, and a DPP-IV inhibitor. Disclosed are a pharmaceutical composition and a fixed dose of a compound preparation, and the methods for preparing the pharmaceutical composition and the fixed dose of the compound preparation and the uses thereof.

公开(公告)号：US20240299304A1

公开(公告)日：2024-09-12

申请号：US18550382

申请日：2022-03-21

申请人： UNIVERSITA DEGLI STUDI DI GENOVA

发明人： Gabriele CAVIGLIOLI ,  Sara BALDASSARI ,  Guendalina ZUCCARI ,  Giorgia AILUNO

IPC分类号： A61K9/24 ,  A61K9/00 ,  A61K9/20 ,  A61K31/155 ,  A61K31/197 ,  A61K31/554

CPC分类号： A61K9/209 ,  A61K9/0065 ,  A61K9/2009 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2095 ,  A61K31/155 ,  A61K31/197 ,  A61K31/554

摘要： A method of preparing a compact bioadhesive, gastroretentive matrix is disclosed. A homogeneous mixture of powders is first prepared which contains an alkylcellulose or an hydroxyalkylcellulose, a water-insoluble, water-swellable cross-linked polycarboxylic polymer and a pH regulator. The mixture of powders is next made into compressed units by direct compression and then heated at a temperature of between 80 and 250° C. for 1-60 minutes. The mixture of powders may also include an active substance. The compressed units thus obtained are characterized by a prolonged release and have a release kinetics of the active substance of substantially zero order in an aqueous solution at pH 1-8.

公开(公告)号：US20240293289A1

公开(公告)日：2024-09-05

申请号：US18593423

申请日：2024-03-01

申请人： University of Maryland, Baltimore

发明人： Mary Anne S. Melo ,  Michael D. Weir ,  Lamia Sami Mokeem

IPC分类号： A61K6/69 ,  A61K6/30 ,  A61K6/71 ,  A61K6/76 ,  A61K31/155 ,  A61K31/695

CPC分类号： A61K6/69 ,  A61K6/30 ,  A61K6/71 ,  A61K6/76 ,  A61K31/155 ,  A61K31/695

摘要： Provided herein are dental adhesives that contain a dental adhesive material and a multifunctional magnetic platform. The multifunctional magnetic platform has a core-shell structure. The core includes magnetic microparticles and an antibiotic with the core capped by an antibacterial silane coating. Also provided are methods utilizing the dental adhesives for increasing longevity of a dental restoration and for restoring a tooth in a subject.

公开(公告)号：US12071673B2

公开(公告)日：2024-08-27

申请号：US16694845

申请日：2019-11-25

申请人： Cedars-Sinai Medical Center

发明人： Mark Pimentel ,  Ruchi Mathur ,  Christopher Chang

IPC分类号： C12Q1/689 ,  A61K31/137 ,  A61K31/155 ,  A61K31/22 ,  A61K31/337 ,  A61K31/351 ,  A61K31/357 ,  A61K31/366 ,  A61K31/40 ,  A61K31/404 ,  A61K31/4164 ,  A61K31/437 ,  A61K31/454 ,  A61K31/47 ,  A61K31/505 ,  A61K31/55 ,  A61K31/7036 ,  A61K31/7048 ,  A61K35/741 ,  A61K45/06

CPC分类号： C12Q1/689 ,  A61K31/137 ,  A61K31/155 ,  A61K31/22 ,  A61K31/337 ,  A61K31/351 ,  A61K31/357 ,  A61K31/366 ,  A61K31/40 ,  A61K31/404 ,  A61K31/4164 ,  A61K31/437 ,  A61K31/454 ,  A61K31/47 ,  A61K31/505 ,  A61K31/55 ,  A61K31/7036 ,  A61K31/7048 ,  A61K35/741 ,  A61K45/06 ,  C12Q2600/106 ,  A61K35/741 ,  A61K2300/00 ,  A61K31/155 ,  A61K2300/00 ,  A61K31/437 ,  A61K2300/00 ,  A61K31/7036 ,  A61K2300/00 ,  A61K31/4164 ,  A61K2300/00 ,  A61K31/40 ,  A61K2300/00 ,  A61K31/404 ,  A61K2300/00 ,  A61K31/366 ,  A61K2300/00 ,  A61K31/47 ,  A61K2300/00 ,  A61K31/22 ,  A61K2300/00 ,  A61K31/505 ,  A61K2300/00 ,  A61K31/137 ,  A61K2300/00 ,  A61K31/7048 ,  A61K2300/00 ,  A61K31/454 ,  A61K2300/00

摘要： The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.

公开(公告)号：US12048770B2

公开(公告)日：2024-07-30

申请号：US16755048

申请日：2018-10-11

申请人： LTS LOHMANN THERAPIE-SYSTEME AG ,  DDP Specialty Electronic Materials US 9, LLC

发明人： Marco Emgenbroich ,  Eva-Marie Prinz ,  Elke Klein ,  Heike Kluth ,  Xavier Thomas ,  Linda Sue Nartker

IPC分类号： A61K9/70 ,  A61K31/155

CPC分类号： A61K9/7084 ,  A61K9/7069 ,  A61K31/155

摘要： The present invention relates to a transdermal therapeutic system for the transdermal administration of guanfacine comprising a guanfacine-containing layer structure, said guanfacine-containing layer structure comprising: A) a backing layer; and B) a guanfacine-containing layer; wherein the transdermal therapeutic system comprises at least one silicone acrylic hybrid polymer.

公开(公告)号：US20240245629A1

公开(公告)日：2024-07-25

申请号：US18444031

申请日：2024-02-16

申请人： Elevaid Therapeutics, Inc.

发明人： Joseph David

IPC分类号： A61K31/122 ,  A61K31/155 ,  A61K45/06 ,  A61P1/00

CPC分类号： A61K31/122 ,  A61K45/06 ,  A61P1/00 ,  A61K31/155

摘要： This disclosure provides a method of reducing steroid use, all-cause hospitalization, and/or advanced therapy use in a subject diagnosed inflammatory bowel disease, Crohn's disease, or ulcerative colitis. In some embodiments, the method comprises administering to the subject a therapeutically effective amount of atovaquone or a salt thereof in combination with proguanil or a salt thereof.

公开(公告)号：US12036236B2

公开(公告)日：2024-07-16

申请号：US17507170

申请日：2021-10-21

申请人： International Business Machines Corporation ,  Agency for Science, Technology and Research

发明人： James L. Hedrick ,  Yi Yan Yang ,  Nathaniel H. Park ,  Victoria A. Piunova ,  Zhi Xiang Voo

IPC分类号： A61K31/765 ,  A61K31/155 ,  C08K5/31 ,  C08L69/00

CPC分类号： A61K31/765 ,  A61K31/155 ,  C08K5/31 ,  C08L69/00

摘要： Compositions and methods regarding antimicrobial guanidinium macromolecules with one or more targeting moieties for selectively targeting bacteria are provided. According to an embodiment, an antimicrobial macromolecule is provided that comprises a polymer backbone and one or more guanidinium moieties that extend from the polymer backbone. The antimicrobial macromolecule further comprises a targeting moiety that extends from the polymer backbone. The targeting moiety can comprise a substance favored for consumption by bacteria, such as a monosaccharide.