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    Nicotine lozenge
    22.
    发明授权
    Nicotine lozenge 有权

    公开(公告)号：US11116758B2

    公开(公告)日：2021-09-14

    申请号：US16897966

    申请日：2020-06-10

    Applicant: Altria Client Services LLC

    Inventor： Feng Gao ,  Diane L. Gee ,  Phillip M. Hulan ,  Shuzhong Zhuang ,  William J. Burke

    IPC: A61K31/465 ,  A61K9/20 ,  A61K9/00 ,  B29C48/00 ,  A61K45/06 ,  B29C48/285

    Abstract: A nicotine lozenge provided herein includes a body that is partially or wholly receivable in an oral cavity. The body includes a soluble-fiber matrix and nicotine or a derivative thereof dispersed in the soluble-fiber matrix. In some cases, a nicotine lozenge provided herein includes at least 40 weight percent of soluble fiber. In some cases, soluble fiber in a nicotine lozenge provided herein can include maltodextrin. The nicotine lozenge is adapted to release the nicotine or a derivative thereof from the body when the body is received within the oral cavity of an adult consumer and exposed to saliva. A method of making nicotine lozenges provided herein includes forming a molten mixture of at least 40 weight percent soluble fiber, nicotine, and less than 15 weight percent water while maintaining a mixture temperature of less than 150° C. and portioning the molten mixture into a plurality of nicotine lozenges. In some cases, the ingredients can be mixed to form the molten mixture in an extruder.

    Nicotine lozenge
    27.
    发明授权
    Nicotine lozenge 有权
    尼古丁锭

    公开(公告)号：US09351936B2

    公开(公告)日：2016-05-31

    申请号：US14506093

    申请日：2014-10-03

    Applicant: ALTRIA CLIENT SERVICES LLC

    Inventor： Feng Gao ,  Diane L. Gee ,  Phillip M. Hulan ,  Shuzhong Zhuang ,  William J. Burke

    IPC: A61K9/20 ,  A61K31/465 ,  A61K9/00 ,  B29C47/00 ,  B29C47/10

    CPC classification number: A61K31/465 ,  A61K9/0056 ,  A61K9/2059 ,  A61K9/2095 ,  A61K45/06 ,  B29C47/0066 ,  B29C47/1081 ,  B29C2793/0009 ,  B29C2793/009

    Abstract: A nicotine lozenge provided herein includes a body that is partially or wholly receivable in an oral cavity. The body includes a soluble-fiber matrix and nicotine or a derivative thereof dispersed in the soluble-fiber matrix. In some cases, a nicotine lozenge provided herein includes at least 40 weight percent of soluble fiber. In some cases, soluble fiber in a nicotine lozenge provided herein can include maltodextrin. The nicotine lozenge is adapted to release the nicotine or a derivative thereof from the body when the body is received within the oral cavity of an adult consumer and exposed to saliva. A method of making nicotine lozenges provided herein includes forming a molten mixture of at least 40 weight percent soluble fiber, nicotine, and less than 15 weight percent water while maintaining a mixture temperature of less than 150° C. and portioning the molten mixture into a plurality of nicotine lozenges. In some cases, the ingredients can be mixed to form the molten mixture in an extruder.

    Abstract translation: 本文提供的尼古丁锭剂包括部分或全部可接收在口腔中的身体。 身体包括分散在可溶性纤维基质中的可溶性纤维基质和尼古丁或其衍生物。 在一些情况下，本文提供的尼古丁锭剂包含至少40重量％的可溶性纤维。 在一些情况下，本文提供的尼古丁锭剂中的可溶性纤维可以包括麦芽糖糊精。 当身体被接收在成人消费者的口腔内并暴露于唾液时，尼古丁锭剂适于将尼古丁或其衍生物从身体释放出来。 本文提供的制备尼古丁锭剂的方法包括形成至少40重量％的可溶性纤维，尼古丁和小于15重量％的水的熔融混合物，同时保持低于150℃的混合物温度，并将熔融混合物分配成 多种尼古丁锭剂。 在一些情况下，可以将这些成分混合以在挤出机中形成熔融混合物。

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