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36 条记录 (耗时 0.035 秒)

    Simultaneously reading different regions of a chemical array
    22.
    发明授权
    Simultaneously reading different regions of a chemical array 失效

    公开(公告)号：US06825929B2

    公开(公告)日：2004-11-30

    申请号：US10261807

    申请日：2002-09-30

    申请人： Andreas N. Dorsel

    发明人： Andreas N. Dorsel

    IPC分类号： G01N2164

    CPC分类号： G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441

    摘要： A method of interrogating an addressable array having a plurality of different chemical features. The method may include simultaneously illuminating different regions of the array with light of different intensities (which, for example, can, but need not be, also of a same waveband). Light emitted from the different regions in response to the illuminating (which light, for example, can, but need not be, of a same waveband) may be simultaneously detected with different detectors. An apparatus, addressable array unit, and related methods are further provided.

    Optical homogenizer
    23.
    发明授权
    Optical homogenizer 失效
    光学均化器

    公开(公告)号：US5973839A

    公开(公告)日：1999-10-26

    申请号：US35369

    申请日：1998-03-05

    申请人： Andreas N. Dorsel

    发明人： Andreas N. Dorsel

    IPC分类号： G02B5/02 ,  G02B6/00 ,  G02B6/42

    CPC分类号： G02B6/00 ,  G02B5/02 ,  G02B6/0001 ,  G02B6/4298

    摘要： An optical homogenizer is disclosed which enables an optical system to obtain the benefits of a high quantum efficiency photon detector without suffering from its non-uniform response. The optical homogenizer has an input end for receiving light emitted from a light source and an output end that produces a relatively uniform distribution of light along a spatial dimension of the photon detector in response to the light source. The optical homogenizer ensures that the photon detector is uniformly illuminated from the output end regardless of where photons from the light source enter the input end.

    摘要翻译： 公开了一种光学均化器，其使光学系统能够获得高量子效率光子检测器的优点，而不会受到其不均匀的响应。 光学均质器具有用于接收从光源发射的光的输入端和响应于光源沿着光子检测器的空间尺寸产生光的相对均匀分布的输出端。 光学均质器确保光子检测器从输出端均匀照明，而不管来自光源的光子是否进入输入端。

    Array scanner control system
    24.
    发明授权
    Array scanner control system 失效
    阵列扫描仪控制系统

    公开(公告)号：US07089123B2

    公开(公告)日：2006-08-08

    申请号：US10261563

    申请日：2002-09-30

    申请人： John F. Corson ,  Andreas N. Dorsel

    发明人： John F. Corson ,  Andreas N. Dorsel

    IPC分类号： G01N33/48

    CPC分类号： G01N21/6452 ,  B01J2219/00659 ,  B01J2219/00693 ,  B01J2219/00702 ,  H04N1/60

    摘要： An optical scanning system adapted to physically adjust scanner settings in response to control feature readings is disclosed. The scanner and methodology finds particular use in reading of biopolymer arrays. The system may operate in any of a number of ways such that optimal data from scans is obtained. It may also be possible to use the system as a tool to aid in manufacture of arrays by providing feedback to a manufacturer regarding the signal produce for a given batch of samples tested.

    摘要翻译： 公开了一种适于物理地调整扫描器设置以响应于控制特征读数的光学扫描系统。 扫描仪和方法在读取生物聚合物阵列时特别有用。 系统可以以多种方式中的任一种操作，从而获得来自扫描的最佳数据。 也可以使用该系统作为工具来帮助制造阵列，通过向制造商提供关于给定批次样品的信号产生的反馈。

    Biopolymer array scanner with real-time saturation detection
    25.
    发明授权
    Biopolymer array scanner with real-time saturation detection 失效
    生物聚合物阵列扫描仪，具有实时饱和度检测

    公开(公告)号：US07013220B2

    公开(公告)日：2006-03-14

    申请号：US10262124

    申请日：2002-09-30

    申请人： Andreas N. Dorsel ,  Jeffrey M. McMillan

    发明人： Andreas N. Dorsel ,  Jeffrey M. McMillan

    IPC分类号： G01N33/50 ,  G01N33/48 ,  G06G7/00 ,  C12Q1/68

    CPC分类号： G01N21/6456 ,  C12Q1/6837 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421

    摘要： Optical scanner system approaches are described in which signal saturation data is produced in real-time. The data generated may be used for tuning a subsequent scan, in protection of optical detector components from damage or otherwise. Approaches for obtaining and storing or expressing the data are also disclosed. Also provided are methods of using the subject system is biopolymer array based application, including genomic and proteomic applications.

    摘要翻译： 描述了实时地产生信号饱和数据的光学扫描器系统方法。 生成的数据可用于调整后续扫描，保护光学检测器部件免受损坏或以其他方式。 还公开了获取和存储或表达数据的方法。 还提供了使用主题系统的方法是基于生物聚合物阵列的应用，包括基因组和蛋白质组学应用。

    Background reduction apparatus and method for confocal fluorescence detection systems
    27.
    发明授权
    Background reduction apparatus and method for confocal fluorescence detection systems 失效
    用于共聚焦荧光检测系统的背景减少装置和方法

    公开(公告)号：US06222664B1

    公开(公告)日：2001-04-24

    申请号：US09359631

    申请日：1999-07-22

    申请人： Andreas N. Dorsel

    发明人： Andreas N. Dorsel

    IPC分类号： G02B2602

    CPC分类号： G02B21/0052 ,  G02B21/0076 ,  Y10S359/90

    摘要： The system includes a confocal optical system to illuminate an object at an intended detection plane and to focus light from the object onto a pinhole. An opaque obstacle is disposed within the confocal optical system, the obstacle selected to suppress light originating outside the intended detection plane from passing through the pinhole. It is preferred that the obstacle size and location be selected to achieve a desired level of suppression. A design goal is a 100-fold reduction in background with a 10% or less loss of signal.

    摘要翻译： 该系统包括共焦光学系统，用于照亮预期检测平面处的物体并将来自物体的光聚焦到针孔上。 不透明障碍物设置在共焦光学系统内，所选择的障碍物用于抑制源自预期检测平面外的光通过针孔。 优选地，选择障碍物大小和位置以实现期望的抑制水平。 设计目标是10％或更少的信号损失背景下降100倍。

    Method and apparatus for reducing the formation of spots in laser projection
    28.
    发明授权
    Method and apparatus for reducing the formation of spots in laser projection 失效
    用于减少激光投影中斑点形成的方法和装置

    公开(公告)号：US6092900A

    公开(公告)日：2000-07-25

    申请号：US873209

    申请日：1997-06-11

    申请人： Frank Diedrich ,  Andreas N. Dorsel

    发明人： Frank Diedrich ,  Andreas N. Dorsel

    IPC分类号： G03B21/14 ,  G03B21/56

    CPC分类号： G03B21/14 ,  G03B21/56 ,  G03B21/608

    摘要： A projection surface includes scattering microparticles that are in constant motion in relation to each other and to a source of laser radiation in a laser projection system. The microparticles reduce the formation of spots that normally occur when viewing the contents of images which are uniformly illuminated by means of laser projection and which are reflected off a projection surface. The microparticles are formed in a suspension fluid and move due to Brownian molecular motion. The fluid is warmed to further increase motion of the microparticles or a piezoelectric force or other mixing mechanism is used to cause turbulence that also increases motion and mixing of the microparticles.

    摘要翻译： 投影表面包括在激光投射系统中相对于彼此恒定运动的散射微粒和激光辐射源。 当观察通过激光投影均匀照射并且从投影表面反射的图像的内容物时，微粒减少通常发生的斑点的形成。 微粒由悬浮液形成，由于布朗分子运动而移动。 加热流体以进一步增加微粒的运动，或者使用压电力或其它混合机构引起也会增加微粒的运动和混合的湍流。

    Method and system for operating a laser device employing an integral power-regulation sensor
    29.
    发明授权
    Method and system for operating a laser device employing an integral power-regulation sensor 失效
    用于操作采用集成功率调节传感器的激光装置的方法和系统

    公开(公告)号：US5763870A

    公开(公告)日：1998-06-09

    申请号：US764910

    申请日：1996-12-13

    申请人： John W. Sadler ,  Andreas N. Dorsel ,  J. Robert Mitchell ,  Mark A. Troll

    发明人： John W. Sadler ,  Andreas N. Dorsel ,  J. Robert Mitchell ,  Mark A. Troll

    IPC分类号： G02B5/30 ,  H01S5/0683 ,  G11B7/00

    CPC分类号： G02B5/3083 ,  H01S5/0683

    摘要： A method and system of operating a laser device includes utilizing an integral power-regulation sensor of the laser device to detect energy back reflected from an object of interest and then using the detected signal as a basis for determining a characteristic related to the object of interest. In the preferred embodiment, the determined characteristic is the position of the beam focus relative to a surface of the object. Also in the preferred embodiment, the integral power-regulation sensor is disconnected from power-regulation circuitry during the focusing operation. Interaction of the back reflected energy and the outgoing beam can be reduced by introducing beam rotation, such as by providing a quarter-wave plate along the beam path. Focusing sensitivity can be increased by locating reflective targets over the surface and by executing AC measurements to filter DC components from the signal.

    摘要翻译： 操作激光装置的方法和系统包括利用激光装置的整体功率调节传感器来检测从感兴趣对象反射的能量，然后使用检测到的信号作为确定与感兴趣对象有关的特征的基础 。 在优选实施例中，确定的特性是相对于物体表面的光束聚焦的位置。 同样在优选实施例中，集中功率调节传感器在聚焦操作期间与功率调节电路断开连接。 通过引入光束旋转，例如通过沿光束路径提供四分之一波片，可以减少后反射能量和输出光束的相互作用。 可以通过将反射目标定位在表面上并通过执行AC测量来从信号中滤除直流分量来提高对焦灵敏度。