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公开(公告)号：US09102639B2
公开(公告)日：2015-08-11
申请号：US14099276
申请日：2013-12-06
Applicant: ARRAY BIOPHARMA INC.
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07D271/107 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D401/12
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：US10017482B2
公开(公告)日：2018-07-10
申请号：US15357613
申请日：2016-11-21
Applicant: ARRAY BIOPHARMA INC.
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07D417/04 , C07D271/107 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/06 , C07D401/12 , C07D417/12 , C07F9/201 , C07F9/6539
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors.
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公开(公告)号：US09499503B2
公开(公告)日：2016-11-22
申请号：US14679866
申请日：2015-04-06
Applicant: ARRAY BIOPHARMA INC.
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
IPC: C07D271/107 , C07D413/04 , C07D417/04 , C07D285/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D401/12 , C07D417/12 , C07F9/201
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors.
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公开(公告)号：US09365568B2
公开(公告)日：2016-06-14
申请号：US14591691
申请日：2015-01-07
Applicant: Array BioPharma Inc.
Inventor： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC: C07D495/14 , C07D471/04 , C07D401/06
CPC classification number: C07D471/04 , C07D401/06 , C07D519/00
Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：US08758830B2
公开(公告)日：2014-06-24
申请号：US13974895
申请日：2013-08-23
Applicant: Array BioPharma Inc.
Inventor： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC: A61K31/4545 , A61K31/437 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/444 , A61K31/501 , A61K35/00 , A61K33/24
CPC classification number: C07D471/04 , C07D401/06 , C07D519/00
Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 式I的化合物可用于抑制CHK1和/或CHK2。 公开了使用式I化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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Patent Agency Ranking
公开(公告)号：US20140100369A1
公开(公告)日：2014-04-10
申请号：US13974895
申请日：2013-08-23
Applicant: Array BioPharma Inc.
Inventor： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D401/06 , C07D519/00
Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：US09969727B2
公开(公告)日：2018-05-15
申请号：US14988521
申请日：2016-01-05
Applicant: Array BioPharma Inc.
Inventor： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC: C07D471/04 , C07D519/00 , C07D401/06
CPC classification number: C07D471/04 , C07D401/06 , C07D519/00
Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：US20150322061A1
公开(公告)日：2015-11-12
申请号：US14591691
申请日：2015-01-07
Applicant: Array BioPharma Inc.
Inventor： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D401/06 , C07D519/00
Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 式I的化合物可用于抑制CHK1和/或CHK2。 公开了使用式I化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US20150210658A1
公开(公告)日：2015-07-30
申请号：US14679866
申请日：2015-04-06
Applicant: ARRAY BIOPHARMA INC.
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07D417/12 , C07F9/201 , C07D417/06
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：US20150191490A1
公开(公告)日：2015-07-09
申请号：US14663286
申请日：2015-03-19
Applicant: Array BioPharma Inc.
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk Delisle , Walter C. Voegtli
IPC: C07D513/04 , C07D285/12 , C07D417/04 , C07D419/04 , C07D497/04
CPC classification number: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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