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公开(公告)号：US09259470B2
公开(公告)日：2016-02-16
申请号：US14181418
申请日：2014-02-14
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： James F. Blake , Mark Joseph Chicarelli , Rustam Ferdinand Garrey , John Gaudino , Jonas Grina , David A. Moreno , Peter J. Mohr , Li Ren , Jacob Schwarz , Huifen Chen , Kirk Robarge , Aihe Zhou
IPC: A61K45/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D409/14 , C07D417/14 , C07D471/04 , A61K31/506 , C07F9/6558 , C07D403/04 , A61K31/513 , A61K31/53 , A61K31/444
CPC classification number: C07D401/04 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586
Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 提供式I化合物或其立体异构体，互变异构体，前药或其药学上可接受的盐，其可用于治疗过度增生，疼痛和炎性疾病。 公开了使用式I化合物或其立体异构体，互变异构体，前药或其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US10154995B2
公开(公告)日：2018-12-18
申请号：US15684733
申请日：2017-08-23
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： James F. Blake , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Tony P. Tang , Allen A. Thomas , Jacob Schwarz , Jane Schmidt , Lewis Gazzard , Huifen Chen
IPC: A61K31/506 , C07D417/14 , C07D405/14 , C07D403/04 , C07D401/14 , C07D471/04 , C07D403/14 , A61K31/4439 , A61K31/444 , A61K45/06
Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：US09763942B2
公开(公告)日：2017-09-19
申请号：US15197479
申请日：2016-06-29
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： James F. Blake , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Tony P. Tang , Allen A. Thomas , Jacob Schwarz , Jane Schmidt , Lewis Gazzard , Huifen Chen
IPC: C07D403/14 , C07D471/04 , C07D417/14 , C07D403/04 , C07D401/14 , A61K31/506 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D405/14
CPC classification number: A61K31/506 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：US20160368916A1
公开(公告)日：2016-12-22
申请号：US14988521
申请日：2016-01-05
Applicant: Array BioPharma Inc.
Inventor： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC: C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , C07D401/06 , C07D519/00
Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：US20170348310A1
公开(公告)日：2017-12-07
申请号：US15684733
申请日：2017-08-23
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： James F. Blake , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Tony P. Tang , Allen A. Thomas , Jacob Schwarz , Jane Schmidt , Lewis Gazzard , Huifen Chen
IPC: A61K31/506 , C07D417/14 , C07D405/14 , C07D403/04 , A61K31/4439 , C07D401/14 , A61K45/06 , A61K31/444 , C07D471/04 , C07D403/14
CPC classification number: A61K31/506 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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Patent Agency Ranking
公开(公告)号：US09670208B2
公开(公告)日：2017-06-06
申请号：US15197445
申请日：2016-06-29
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： James F. Blake , Adam Cook , John Gaudino , Indrani W. Gunawardana , Erik James Hicken , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Jacob Schwarz , Huifen Chen , Lewis Gazzard , Jane Schmidt , Steve Do
IPC: C07D471/04 , A61K45/06 , A61K31/5377 , A61K31/506 , A61K31/444 , C07D487/04 , C07D519/00 , A61K31/55
CPC classification number: C07D471/04 , A61K31/444 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04 , C07D519/00
Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.
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公开(公告)号：US08981085B2
公开(公告)日：2015-03-17
申请号：US14271129
申请日：2014-05-06
Applicant: Array BioPharma Inc.
Inventor： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D401/06 , C07D519/00
Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 式I的化合物可用于抑制CHK1和/或CHK2。 公开了使用式I化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US20140249127A1
公开(公告)日：2014-09-04
申请号：US14181418
申请日：2014-02-14
Applicant: Genentech, Inc. , Array BioPharma Inc.
Inventor： James F. Blake , Mark Joseph Chicarelli , Rustam Ferdinand Garrey , John Gaudino , Jonas Grina , David A. Moreno , Peter J. Mohr , Li Ren , Jacob Schwarz , Huifen Chen , Kirk Robarge , Aihe Zhou
IPC: C07D417/14 , C07D409/14 , C07D401/14 , C07D413/14 , C07D405/14 , C07D401/04
CPC classification number: C07D401/04 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586
Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 提供式I化合物或其立体异构体，互变异构体，前药或其药学上可接受的盐，其可用于治疗过度增生，疼痛和炎性疾病。 公开了使用式I化合物或其立体异构体，互变异构体，前药或其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US08697715B2
公开(公告)日：2014-04-15
申请号：US13782513
申请日：2013-03-01
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： James F. Blake , Mark Joseph Chicarelli , Rustam Ferdinand Garrey , John Gaudino , Jonas Grina , David A. Moreno , Peter J. Mohr , Li Ren , Jacob Schwarz , Huifen Chen , Kirk Robarge , Aihe Zhou
IPC: A01N43/54 , A61K31/505
CPC classification number: C07D401/04 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586
Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 提供式I化合物或其立体异构体，互变异构体，前药或其药学上可接受的盐，其可用于治疗过度增生，疼痛和炎性疾病。 公开了使用式I化合物或其立体异构体，互变异构体，前药或其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US10519126B2
公开(公告)日：2019-12-31
申请号：US15625297
申请日：2017-06-16
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： James F. Blake , Mark Joseph Chicarelli , Rustam Ferdinand Garrey , John Gaudino , Jonas Grina , David A. Moreno , Peter J. Mohr , Li Ren , Jacob Schwarz , Huifen Chen , Kirk Robarge , Aihe Zhou
IPC: C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D409/14 , C07D417/14 , C07D471/04 , A61K31/506 , A61K45/06 , C07F9/6558 , C07D403/04 , A61K31/513 , A61K31/53 , A61K31/444
Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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