公开(公告)号：US10851410B2

公开(公告)日：2020-12-01

申请号：US15862566

申请日：2018-01-04

Applicant: MGI Tech Co., Ltd. ,  BGI Shenzhen

Inventor： Radoje Drmanac ,  Snezana Drmanac ,  Handong Li ,  Xun Xu ,  Matthew J. Callow ,  Leon Eckhardt ,  Naibo Yang

IPC: C12P19/34 ,  C12Q1/6874 ,  C12Q1/6876 ,  C07K16/44 ,  C12Q1/6804 ,  A61K47/00 ,  C12Q1/6869 ,  C07K16/28

Abstract: The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.