公开(公告)号：US20180325899A1

公开(公告)日：2018-11-15

申请号：US15776094

申请日：2016-11-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： David S. Weinstein ,  Ryan M. Moslin ,  Yanlei Zhang ,  Daniel S. Gardner ,  Joseph B. Santella ,  Charles M. Langevine ,  Sylwia Stachura

IPC: A61K31/5025 ,  A61K31/53 ,  A61K31/5377 ,  A61P29/00 ,  A61P37/02

CPC classification number: A61K31/5025 ,  A61K31/53 ,  A61K31/5377 ,  A61P29/00 ,  A61P37/02 ,  C07D487/04

Abstract: Compounds of formula I or a stereoisomer or pharmaceutically-acceptable salt thereof, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.