公开(公告)号：US08703718B2

公开(公告)日：2014-04-22

申请号：US13795545

申请日：2013-03-12

Applicant: Bristol-Myers Squibb Company

Inventor： Robert Cohen ,  Suzette Belder-Carr ,  David Hagerty ,  Robert James Peach ,  Jean-Claude Becker

IPC: A61K38/16

CPC classification number: A61K38/1774 ,  A61K38/00 ,  A61K39/0008 ,  A61K39/395 ,  A61K47/6811 ,  C07K14/70521 ,  C07K2319/00

Abstract: The present invention relates to compositions and methods for treating autoimmune diseases, such as juvenile rheumatoid arthritis, by administering to a subject a CTLA4 molecule that block endogenous B7 molecules from binding their ligands.

Abstract translation: 本发明涉及通过向受试者施用阻断内源性B7分子结合其配体的CTLA4分子来治疗自身免疫性疾病如青少年类风湿性关节炎的组合物和方法。

公开(公告)号：US08674076B2

公开(公告)日：2014-03-18

申请号：US13711855

申请日：2012-12-12

Applicant: Bristol-Myers Squibb Company

Inventor： Glen Eugene Mikesell ,  Han Chang ,  Robert James Peach

IPC: C07K14/00 ,  C07K16/46

CPC classification number: C07K14/70532 ,  A61K38/00 ,  A61K38/1774 ,  A61K39/39533 ,  A61K2039/505 ,  C07K16/2827 ,  C07K19/00 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/10 ,  C07K2319/30 ,  C07K2319/40 ,  G01N33/5005 ,  Y02A50/396

Abstract: The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

Abstract translation: 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。