公开(公告)号：US20240352151A1

公开(公告)日：2024-10-24

申请号：US18594693

申请日：2024-03-04

申请人： CRISPR Therapeutics AG

发明人： Jason Sagert ,  Jui Dutta-Simmons ,  Jonathan Alexander Terrett

IPC分类号： C07K16/40 ,  A61K35/17 ,  A61K38/00 ,  A61K39/00 ,  A61P35/00 ,  C07K7/08 ,  C07K14/47 ,  C07K14/705 ,  C07K14/725 ,  C12N5/0783

CPC分类号： C07K16/40 ,  A61K35/17 ,  A61P35/00 ,  C07K7/08 ,  C07K14/47 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70578 ,  C12N5/0636 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/5158 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/50 ,  C12N2510/00

摘要： Masked chimeric antigen receptor (CAR) constructs comprising an extracellular antigen binding domain specific tyrosine-protein kinase-like 7 (PTK7), which is linked to a mask peptide that blocks binding of masked CAR from binding to PTK7. Also provided herein are genetically engineered T cells expressing a masked CAR specific to PTK7 and therapeutic uses thereof.

公开(公告)号：US12122820B2

公开(公告)日：2024-10-22

申请号：US16988415

申请日：2020-08-07

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： James L. Riley ,  Rachel Leibman ,  Aimee S. Payne ,  Christoph T. Ellebrecht ,  Michael C. Milone

IPC分类号： C07H21/04 ,  A61K35/17 ,  A61K38/17 ,  A61K39/42 ,  A61K45/06 ,  A61K48/00 ,  A61P31/18 ,  C07K14/705 ,  C07K14/725 ,  C07K14/73 ,  C07K16/10 ,  C12N15/63 ,  A01K67/00 ,  A61K39/00

CPC分类号： C07K14/70514 ,  A61K35/17 ,  A61K38/1774 ,  A61K39/42 ,  A61K45/06 ,  A61P31/18 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70578 ,  C07K16/1045 ,  A61K2039/505 ,  A61K2039/5158 ,  A61K2039/572 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/33

摘要： The present invention relates to compositions and methods for treating of a HIV infected mammal using a CD4 membrane-bound chimeric receptor or a HIV specific scFvs CARs. One aspect includes a modified T cell and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with HIV infection.

公开(公告)号：US20240343776A1

公开(公告)日：2024-10-17

申请号：US18620255

申请日：2024-03-28

申请人： Kashiv BioSciences, LLC

发明人： Om Narayan ,  Kishor Galani ,  Rupen Bhavsar ,  Roshan Ganeshlal Upadhyay

IPC分类号： C07K14/705 ,  C07K1/18

CPC分类号： C07K14/70521 ,  C07K1/18 ,  C07K2319/30

摘要： The present invention is directed to the use of anion exchange chromatography to produce a CTLA4-Ig fusion protein with improve glycan.

公开(公告)号：US20240336699A1

公开(公告)日：2024-10-10

申请号：US18750233

申请日：2024-06-21

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Sonny Oon ANG ,  Enli LIU ,  Elizabeth SHPALL ,  Katy REZVANI

IPC分类号： C07K16/28 ,  A61K35/17 ,  A61K38/00 ,  A61K39/00 ,  A61P37/06 ,  C07K14/54 ,  C07K14/705 ,  C07K14/71 ,  C07K14/725 ,  C12N15/52 ,  C12N15/86

CPC分类号： C07K16/2896 ,  A61K35/17 ,  A61P37/06 ,  C07K14/5443 ,  C07K14/70503 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/71 ,  C07K16/2803 ,  C07K16/2863 ,  C12N15/52 ,  C12N15/86 ,  A61K38/00 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61K2039/572 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/33

摘要： Provided herein are chimeric antigen receptors (CARs) comprising a truncated EGFRvIII (Ev3) in the hinge region of the CAR and/or a humanized scFv. Further provided herein are immune cells expressing the CARs as well as methods of their use in the treatment of immune disorders.

公开(公告)号：US20240335538A1

公开(公告)日：2024-10-10

申请号：US18290668

申请日：2022-07-21

申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

发明人： Tae-Don KIM ,  Sooyun LEE

IPC分类号： A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C07K14/73 ,  C07K14/735 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  C12N5/0783

CPC分类号： A61K39/464404 ,  A61K39/4611 ,  A61K39/4613 ,  A61K39/4614 ,  A61K39/4615 ,  A61K39/4631 ,  A61K39/464406 ,  A61K39/464411 ,  A61K39/464419 ,  A61K39/464429 ,  A61K39/464466 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70514 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70532 ,  C07K14/70535 ,  C07K14/7056 ,  C07K14/70575 ,  C07K14/70578 ,  C07K14/70596 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2827 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/303 ,  C07K16/32 ,  C12N5/0646 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C12N2510/00

摘要： The present invention relates to: a novel chimeric antigen receptor containing, as an intracellular signaling domain, an intracellular domain of a receptor containing a dead region; and immune cells expressing the chimeric antigen receptor. In environments in which normal cells are present, the immune cells expressing the chimeric antigen receptor according to the present invention exhibit little or no cytotoxicity and cell death of the immune cells is exhibited, thus ensuring the stability of the normal cells. Conversely, in environments in which target cells are present, the immune cells exhibit more potent cytotoxicity than with conventional techniques utilizing a lone chimeric antigen receptor.

公开(公告)号：US12110340B2

公开(公告)日：2024-10-08

申请号：US16408510

申请日：2019-05-10

申请人： Proplex Technologies, LLC

发明人： Frank N. Chang ,  George P. Tuszynski ,  Solomon Luo ,  Jeff Yang

IPC分类号： C07K16/30 ,  A61P35/00 ,  C07K14/705 ,  C07K14/71 ,  C07K14/725 ,  C12N5/0783 ,  G01N33/574

CPC分类号： C07K16/30 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/71 ,  C12N5/0638 ,  G01N33/57488 ,  G01N33/57492 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2319/02 ,  C07K2319/03

摘要： A method for detecting cells having granules expressing G protein coupled receptor-associated sorting protein 1 (GASP-1) or a fragment thereof is provided. The detection method may comprise: (a) contacting the cells with an effective amount of a binding protein, wherein the binding protein comprises an antigen binding fragment that specifically binds GASP-1; and (b) identifying cells having granules bound to the binding protein. The GASP-1 granules may be in the cytosol or on the surface of the cells. Also provided are methods for producing T-cells comprising a chimeric antigen receptor, anti-GASP-1 antibody or a bi-specific binding protein. Further provided are methods for treating GASP-1-mediated to disease or inactivating exosomes, microvesicles or oncosomes.

公开(公告)号：US12103973B2

公开(公告)日：2024-10-01

申请号：US17279391

申请日：2019-09-26

申请人： FUZHOU TCELLTECH BIOTECHNOLOGY CO., LTD. ,  Tcelltech Inc.

发明人： Gangxiong Huang ,  Liqun Luo

IPC分类号： C07K16/28 ,  A61K35/17 ,  A61K38/00 ,  A61K39/00 ,  A61K47/68 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C12N5/0783 ,  G01N33/68

CPC分类号： C07K16/2827 ,  A61K35/17 ,  A61K47/6849 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70578 ,  C12N5/0636 ,  G01N33/68 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/30 ,  C07K2319/33 ,  C12N2510/00 ,  G01N2333/70532

摘要： The present invention provides an anti-B7-H3 monoclonal antibody and use thereof in cell therapy. Specifically, the present invention provides an scFv, an antibody, and a specific CAR-T cell specifically targeting B7-H3. The present invention further provides an engineered immune cell capable of co-expressing a CAR targeting B7-H3 and a chimeric molecule or a secreted protein of PD-L1, the engineered immune cell having good tumor killing effects.

公开(公告)号：US20240317894A1

公开(公告)日：2024-09-26

申请号：US18619607

申请日：2024-03-28

申请人： The Board of Regents of the University of Oklahoma

发明人： Zhizhuang Zhao ,  Suraj Pratap

IPC分类号： C07K16/40 ,  A61K39/00 ,  A61P35/02 ,  C07K14/705 ,  C07K14/725 ,  C12N5/0783

CPC分类号： C07K16/40 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464462 ,  A61P35/02 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70578 ,  C12N5/0636 ,  C07K2317/74 ,  C07K2319/02 ,  C07K2319/03 ,  C12N2510/00

摘要： A chimeric antigen receptor (CAR) comprising (1) an extracellular portion of human Fms-related tyrosine kinase 3 ligand (FLT3L) that binds to Fms-related tyrosine kinase 3 (FLT3), (2) a transmembrane domain, (3) a costimulatory signaling domain, and (4) an intracellular signaling domain. A nucleic acid sequence encoding the CAR. A vector and cell comprising the nucleic acid sequence encoding the CAR. A cell expressing the CAR. A composition of cells expressing the CAR. A method of administering the composition of cells expressing the CAR to a subject for stimulating in the subject an immune response against cells which express FLT3.

公开(公告)号：US20240299451A1

公开(公告)日：2024-09-12

申请号：US18441467

申请日：2024-02-14

申请人： CASE WESTERN RESERVE UNIVERSITY

发明人： Reshmi Parameswaran

IPC分类号： A61K35/17 ,  A61K38/17 ,  A61K39/00 ,  A61K45/06 ,  A61P35/02 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28

CPC分类号： A61K35/17 ,  A61K38/177 ,  A61K38/1774 ,  A61K45/06 ,  A61P35/02 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70575 ,  C07K14/70578 ,  C07K16/2803 ,  A61K2039/505 ,  C07K2317/76 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/33

摘要： The disclosure relates generally to ligand-based chimeric antigen receptor (CAR) cells. More specifically, the CAR cells express B-cell activating factor (BAFF) protein for recognition by a receptor of BAFF on the surface of a cell. CAR cells can include cytotoxic T lymphocytes, natural killer (NK) cells or natural killer T (NKT) cells that express a chimeric receptor that recognizes a receptor of BAFF. The disclosure further relates to methods of treating a variety of conditions, such as cancers and autoimmune diseases, using the disclosed CAR cells.

公开(公告)号：US12084487B2

公开(公告)日：2024-09-10

申请号：US18357979

申请日：2023-07-24

申请人： Emory University

发明人： Lily Yang ,  Erica Bozeman

IPC分类号： C07K14/705 ,  A61K31/405 ,  A61K31/4245 ,  A61K31/7088 ,  A61K38/00 ,  A61K38/17 ,  A61K38/48 ,  A61K45/06 ,  A61K47/62 ,  A61K47/69 ,  A61K49/00 ,  A61K49/18 ,  A61K51/08 ,  A61P35/02 ,  C07K14/47 ,  C07K14/78 ,  G01N33/574 ,  B82Y5/00

CPC分类号： C07K14/70521 ,  A61K31/405 ,  A61K31/4245 ,  A61K31/7088 ,  A61K38/177 ,  A61K38/482 ,  A61K38/4886 ,  A61K45/06 ,  A61K47/62 ,  A61K47/6929 ,  A61K47/6939 ,  A61K49/0002 ,  A61K49/0093 ,  A61K49/1866 ,  A61K51/08 ,  A61P35/02 ,  C07K14/70596 ,  C12Y304/21073 ,  C12Y304/2408 ,  G01N33/574 ,  B82Y5/00 ,  C07K2319/21 ,  A61K31/405 ,  A61K2300/00 ,  A61K31/4245 ,  A61K2300/00

摘要： This disclosure relates to peptides and nanoparticles comprising a surface molecule that binds or blocks PD-L1. In certain embodiments, the disclosure relates to methods of using peptides or nanoparticles disclosed herein for the treatment of cancer. In certain embodiments, the disclosure relates to methods of using nanoparticles disclosed herein for therapeutic and diagnostic applications.