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21.发明授权Substituted pyrrolopyrimidinylamino-benzothiazolones as MKNK kinase inhibitors 有权取代的吡咯并嘧啶基氨基 - 苯并噻唑酮作为MKNK激酶抑制剂公开(公告)号：US09382255B2
公开(公告)日：2016-07-05
申请号：US14429927
申请日：2013-09-18
发明人： Ulrich Klar , Lars Wortmann , Georg Kettschau , Florian Püehler , Philip Lienau , Kirstin Petersen , Andrea Hägebarth , Detlev Sülzle , Anja Richter
IPC分类号： A01N43/90 , A61K31/519 , C07D471/00 , C07D487/00 , C07D491/00 , C07D487/04 , C07D473/00 , A61K45/06 , A61K31/52 , A61K31/5377 , C07D473/34
CPC分类号： C07D487/04 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted pyrrolopyrimidinylamino-benzothiazolone compounds of general formula I as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及本文所述和定义的通式I的取代吡咯并嘧啶基氨基 - 苯并噻唑酮化合物，涉及制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述 用于制造用于治疗或预防疾病，特别是高增殖和/或血管生成障碍的药物组合物作为唯一试剂或与其它活性成分组合的化合物。
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公开(公告)号：US20160159789A1
公开(公告)日：2016-06-09
申请号：US14903423
申请日：2014-07-04
发明人： Ulrich Klar , Lars Wortmann , Georg Kettschau , Keith Graham , Anja Richter , Philip Lienau , Florian Puehler , Kirstin Petersen , Franziska Siegel , Detlev Sulzle
IPC分类号： C07D471/04 , A61K31/519 , A61K31/5377 , C07D519/00
CPC分类号： C07D471/04 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： The present invention relates to substituted pyrazolopyridine compounds of general formula I as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及如本文所述和定义的通式I的取代吡唑并吡啶化合物，制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述化合物用于 制造用于治疗或预防疾病，特别是过度增殖和/或血管生成障碍的药物组合物，作为唯一试剂或与其它活性成分组合。
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23.发明申请SUBSTITUTED INDAZOL-PYRROLOPYRIMIDINES USEFUL IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES 审中-公开用于治疗高增殖性疾病的替代的吲哚酚吡咯烷酮公开(公告)号：US20150252047A1
公开(公告)日：2015-09-10
申请号：US14431656
申请日：2013-09-23
发明人： Ulrich Klar , Lars Wortmann , Georg Kettschau , Florian Puehler , Philip Lienau , Kirstin Petersen , Andrea Hägebarth , Detlev Sülzle , Keith Graham , Anja Richter
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K45/06
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K45/06
摘要： The present invention relates to substituted indazol-pyrrolopyrimidine compounds of general formula (I): in which R1a, R1b, R1c, R1d, R2a and R2b are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的取代的吲唑并吡咯并嘧啶化合物：其中R1a，R1b，R1c，R1d，R2a和R2b如本文所述和定义，与制备所述化合物的方法相关，可用于制备 所述化合物，包含所述化合物的药物组合物和组合以及用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物的所述化合物用作单一药剂或 与其他活性成分组合。
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公开(公告)号：US20150152121A1
公开(公告)日：2015-06-04
申请号：US14402665
申请日：2013-05-17
发明人： Ulrich Klar , Georg Kettschau , Dirk Kosemund , Florian Pühler , Knut Eis , Philip Lienau , Ulf Bömer , Detlev Sülzle , Lars Wortmann
IPC分类号： C07D495/04 , C07D519/00 , A61K45/06 , A61K31/519
CPC分类号： C07D495/04 , A61K31/38 , A61K31/519 , A61K45/06 , C07D519/00
摘要： The present invention relates to substituted benzothienopyrimidine compounds of general formula I: in which R1a, R1b, R2a, R2b, and R2c are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式I的取代的苯并噻吩并嘧啶化合物：其中R1a，R1b，R2a，R2b和R2c如本文所述和定义，涉及制备所述化合物的方法，可用于制备所述化合物的中间体化合物， 包含所述化合物的组合物和组合以及所述化合物用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物作为唯一试剂或与其它活性物质组合的用途 配料。
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公开(公告)号：US10428044B2
公开(公告)日：2019-10-01
申请号：US15317924
申请日：2015-06-17
发明人： Keith Graham , Ulrich Klar , Hans Briem , Marion Hitchcock , Lars Bärfacker , Knut Eis , Volker Schulze , Gerhard Siemeister , Wilhelm Bone , Jens Schröder , Simon Holton , Philip Lienau , René Tempel , Helmut Sonnenschein , Jozsef Bálint , Heinz Graubaum
IPC分类号： C07D401/04 , A61K31/4439 , C07D403/04 , A61K31/506 , C07D401/14 , A61K31/444 , C07D405/14 , C07D471/04 , A61K31/437 , A61K31/501 , A61K31/4725 , C07D409/14 , A61K31/4709 , A61K31/5377 , C07D491/056 , A61K31/436 , C07D417/14 , C07D413/14 , A61K45/06
摘要： Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号：US09675612B2
公开(公告)日：2017-06-13
申请号：US14772693
申请日：2014-03-03
发明人： Ulrich Klar , Lars Wortmann , Keith Graham , Florian Puehler , Detlev Sülzle , Georg Kettschau , Philip Lienau
IPC分类号： A61K31/497 , C07D239/70 , C07D513/04
CPC分类号： A61K31/497 , C07D239/70 , C07D513/04
摘要： The present invention relates to substituted thiazolopyrimidine compounds of general formula I as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US09540392B2
公开(公告)日：2017-01-10
申请号：US14403151
申请日：2013-05-17
发明人： Georg Kettschau , Florian Puehler , Knut Eis , Ulrich Klar , Dirk Kosemund , Detlev Sülzle , Philip Lienau , Andrea Hägebarth , Ulf Bömer , Lars Wortmann , Keith Graham , Antje Margret Wengner
IPC分类号： C07D495/04 , C07D519/00 , A61K31/519 , A61P19/02 , A61K31/5377 , A61K31/541 , A61K31/5513 , A61K45/06
CPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/5513 , A61K45/06 , C07D519/00
摘要： The present invention relates to substituted thienopyrimidine compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及如本文所述和定义的通式（I）的取代的噻吩并嘧啶化合物，制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述 用于制造用于治疗或预防疾病，特别是高增殖和/或血管生成障碍的药物组合物作为唯一试剂或与其它活性成分组合的化合物。
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公开(公告)号：US20160016959A1
公开(公告)日：2016-01-21
申请号：US14771648
申请日：2014-02-25
发明人： Marcus Koppitz , Ulrich Klar , Antje Margret Wengner , Roland Neuhaus , Gerhard Siemeister , Michael Bruning
IPC分类号： C07D487/04 , A61K39/395 , A61K33/24 , A61K31/282 , A61K31/675 , A61K31/7068 , A61K31/52 , A61K38/14 , A61K31/573 , A61K31/704 , A61K31/5025 , A61K31/69
CPC分类号： C07D487/04 , A61K31/282 , A61K31/4188 , A61K31/5025 , A61K31/52 , A61K31/573 , A61K31/675 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K38/14 , A61K39/3955 , A61K2039/505 , C07D237/00
摘要： The present invention relates to substituted imidazopyridazine compounds, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及取代的咪唑并哒嗪化合物，制备所述化合物的方法，药物组合物和包含所述化合物的组合以及所述化合物用于制备药物组合物用于治疗或预防疾病，特别是超级 增殖和/或血管生成障碍，作为唯一的药剂或与其它活性成分组合。
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29.发明申请SUBSTITUTED PYRROLOPYRIMIDINYLAMINO-BENZOTHIAZOLONES AS MKNK KINASE INHIBITORS 有权作为MKNK激酶抑制剂的取代的吡咯烷基亚胺基苯并噻唑公开(公告)号：US20150239891A1
公开(公告)日：2015-08-27
申请号：US14429927
申请日：2013-09-18
发明人： Ulrich Klar , Lars Wortmann , Georg Kettschau , Florian Püehler , Philip Lienau , Kirstin Petersen , Andrea Hägebarth , Detlev Sülzle , Anja Richter
IPC分类号： C07D487/04 , A61K45/06 , A61K31/52 , A61K31/5377 , A61K31/519 , C07D473/34
CPC分类号： C07D487/04 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted pyrrolopyrimidinylamino-benzothiazolone compounds of general formula I as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及本文所述和定义的通式I的取代吡咯并嘧啶基氨基 - 苯并噻唑酮化合物，涉及制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述 用于制造用于治疗或预防疾病，特别是高增殖和/或血管生成障碍的药物组合物作为唯一试剂或与其它活性成分组合的化合物。
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公开(公告)号：US20150133426A1
公开(公告)日：2015-05-14
申请号：US14403154
申请日：2013-05-17
发明人： Ulrich Klar , Georg Kettschau , Detlev Sülzle , Florian Puehler , Dirk Kosemund , Philip Lienau , Ulf Bömer , Lars Wortmann
IPC分类号： C07D491/20 , A61K31/519 , C07D487/16 , C07D495/14 , A61K31/5377 , C07D487/04 , C07D487/14
CPC分类号： C07D491/20 , A61K31/519 , A61K31/5377 , C07D487/04 , C07D487/14 , C07D487/16 , C07D495/14
摘要： The present invention relates to substituted pyrrolopyrimidine compounds general formula I: in which A, X, R1, R2, m and n are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式I的取代吡咯并嘧啶化合物：其中A，X，R 1，R 2，m和n如本文所述和定义，涉及制备所述化合物的方法，可用于制备所述化合物的中间体化合物， 包含所述化合物的组合物和组合以及所述化合物用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物作为唯一试剂或与其它活性物质组合的用途 配料。
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