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![4H-pyrrolo[3,2-c]pyridin-4-one derivatives](/abs-image/US/2022/05/24/US11339157B1/abs.jpg.150x150.jpg)
公开(公告)号：US11339157B1
公开(公告)日：2022-05-24
申请号：US16758018
申请日：2018-10-23
申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , Dana-Farber Cancer Institute, Inc. , The Broad Institute, Inc.
发明人： Stephan Siegel , Franziska Siegel , Volker Schulze , Markus Berger , Keith Graham , Ulrich Klar , Knut Eis , Detlev Sülzle , Ulf Bömer , Daniel Korr , Kirstin Petersen , Ursula Mönning , Uwe Eberspächer , Dieter Moosmayer , Matthew Meyerson , Heidi Greulich , Bethany Kaplan , Hassan Youssef Harb , Phi Manh Dinh
IPC分类号： C07D471/04 , A61P35/00 , A61K45/06
摘要： Compounds of formula (I) processes for their production and their use as pharmaceuticals.
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公开(公告)号：US20160159789A1
公开(公告)日：2016-06-09
申请号：US14903423
申请日：2014-07-04
发明人： Ulrich Klar , Lars Wortmann , Georg Kettschau , Keith Graham , Anja Richter , Philip Lienau , Florian Puehler , Kirstin Petersen , Franziska Siegel , Detlev Sulzle
IPC分类号： C07D471/04 , A61K31/519 , A61K31/5377 , C07D519/00
CPC分类号： C07D471/04 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： The present invention relates to substituted pyrazolopyridine compounds of general formula I as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及如本文所述和定义的通式I的取代吡唑并吡啶化合物，制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述化合物用于 制造用于治疗或预防疾病，特别是过度增殖和/或血管生成障碍的药物组合物，作为唯一试剂或与其它活性成分组合。
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3.发明申请SUBSTITUTED INDAZOL-PYRROLOPYRIMIDINES USEFUL IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES 审中-公开用于治疗高增殖性疾病的替代的吲哚酚吡咯烷酮公开(公告)号：US20150252047A1
公开(公告)日：2015-09-10
申请号：US14431656
申请日：2013-09-23
发明人： Ulrich Klar , Lars Wortmann , Georg Kettschau , Florian Puehler , Philip Lienau , Kirstin Petersen , Andrea Hägebarth , Detlev Sülzle , Keith Graham , Anja Richter
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K45/06
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K45/06
摘要： The present invention relates to substituted indazol-pyrrolopyrimidine compounds of general formula (I): in which R1a, R1b, R1c, R1d, R2a and R2b are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的取代的吲唑并吡咯并嘧啶化合物：其中R1a，R1b，R1c，R1d，R2a和R2b如本文所述和定义，与制备所述化合物的方法相关，可用于制备 所述化合物，包含所述化合物的药物组合物和组合以及用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物的所述化合物用作单一药剂或 与其他活性成分组合。
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![4H-pyrrolo[3,2-C]pyridin-4-one derivatives](/abs-image/US/2019/10/01/US10428063B2/abs.jpg.150x150.jpg)
公开(公告)号：US10428063B2
公开(公告)日：2019-10-01
申请号：US15547032
申请日：2016-01-25
发明人： Keith Graham , Ulrich Klar , Hans Briem , Volker Schulze , Gerhard Siemeister , Philip Lienau , René Tempel , Jozsef Bálint
IPC分类号： C07D471/04 , C07D405/14 , C07D401/12 , A61K31/437 , A61K31/444 , A61K45/06 , C07D519/00
摘要： Compound of formula (I), processes for their production and their use as pharmaceuticals.
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公开(公告)号：US10308629B2
公开(公告)日：2019-06-04
申请号：US15750103
申请日：2016-08-01
发明人： Keith Graham , Ulrich Klar , Hans Briem , Gerhard Siemeister , Ursula Mönning
IPC分类号： A61K31/403 , A61K31/407 , A61K31/4439 , A61P35/00 , C07D401/04 , C07D401/14 , C07D487/14 , C07D405/14 , C07D403/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/056 , C07D487/04 , A61K45/06
摘要： Compounds of formula (I) as described herein, processes for their production and their use as pharmaceuticals.
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公开(公告)号：US10227299B2
公开(公告)日：2019-03-12
申请号：US15737182
申请日：2016-06-14
发明人： Keith Graham , Ulrich Klar , Hans Briem , Gerhard Siemeister , Ursula Mönning , Jozsef Balint
IPC分类号： C07D209/40 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/056 , A61P35/04 , A61K31/403 , C07C327/46
摘要： Compounds of formula (I) as described herein processes for their production and their use as anti-cancer agents.
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7.发明申请SUBSTITUTED INDAZOL-PYRROLOPYRIMIDINES USEFUL IN THE TREATMENT OF HYPERFOLIFERATIVE DISORDERS 审中-公开替代治疗高血压疾病有用的吲哚酚吡咯烷酮公开(公告)号：US20150218173A1
公开(公告)日：2015-08-06
申请号：US14431674
申请日：2013-09-24
发明人： Lars Wortmann , Ulrich Klar , Georg Kettschau , Florian Puehler , Philip Lienau , Kirstin Petersen , Andrea Hägebarth , Detlev Sülzle , Keith Graham , Anja Richter
IPC分类号： C07D487/04 , A61K31/5377 , A61K45/06 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K45/06
摘要： The present invention relates to substituted indazol-pyrrolopyrimidine compounds of general formula I: in which R1a, R1b, R1c, R1d, R2a are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式I的取代的吲唑并吡咯并嘧啶化合物：其中R1a，R1b，R1c，R1d，R2a如本文所述和定义，涉及制备所述化合物的方法，可用于制备所述化合物的中间体化合物， 包含所述化合物的药物组合物和组合以及用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物的所述化合物作为唯一试剂或与其它组合物组合的用途 有效成分。
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公开(公告)号：US20150133425A1
公开(公告)日：2015-05-14
申请号：US14403151
申请日：2013-05-17
发明人： Georg Kettschau , Florian Puehler , Knut Eis , Ulrich Klar , Dirk Kosemund , Detlev Sülzle , Philip Lienau , Andrea Hägebarth , Ulf Bömer , Lars Wortmann , Keith Graham , Antje Margret Wengner
IPC分类号： C07D495/04 , A61K31/5377 , A61K45/06 , A61K31/541 , C07D519/00 , A61K31/519 , A61K31/5513
CPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/5513 , A61K45/06 , C07D519/00
摘要： The present invention relates to substituted thienopyrimidine compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及如本文所述和定义的通式（I）的取代的噻吩并嘧啶化合物，制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述 用于制造用于治疗或预防疾病，特别是高增殖和/或血管生成障碍的药物组合物作为唯一试剂或与其它活性成分组合的化合物。
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公开(公告)号：US10428044B2
公开(公告)日：2019-10-01
申请号：US15317924
申请日：2015-06-17
发明人： Keith Graham , Ulrich Klar , Hans Briem , Marion Hitchcock , Lars Bärfacker , Knut Eis , Volker Schulze , Gerhard Siemeister , Wilhelm Bone , Jens Schröder , Simon Holton , Philip Lienau , René Tempel , Helmut Sonnenschein , Jozsef Bálint , Heinz Graubaum
IPC分类号： C07D401/04 , A61K31/4439 , C07D403/04 , A61K31/506 , C07D401/14 , A61K31/444 , C07D405/14 , C07D471/04 , A61K31/437 , A61K31/501 , A61K31/4725 , C07D409/14 , A61K31/4709 , A61K31/5377 , C07D491/056 , A61K31/436 , C07D417/14 , C07D413/14 , A61K45/06
摘要： Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号：US09675612B2
公开(公告)日：2017-06-13
申请号：US14772693
申请日：2014-03-03
发明人： Ulrich Klar , Lars Wortmann , Keith Graham , Florian Puehler , Detlev Sülzle , Georg Kettschau , Philip Lienau
IPC分类号： A61K31/497 , C07D239/70 , C07D513/04
CPC分类号： A61K31/497 , C07D239/70 , C07D513/04
摘要： The present invention relates to substituted thiazolopyrimidine compounds of general formula I as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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