公开(公告)号：US06299599B1

公开(公告)日：2001-10-09

申请号：US09427745

申请日：1999-10-27

申请人： Nora Tran Pham ,  Lynn M. Shimada ,  Scott M. Evans ,  Blair D. Walker

发明人： Nora Tran Pham ,  Lynn M. Shimada ,  Scott M. Evans ,  Blair D. Walker

IPC分类号： A61F712

CPC分类号： A61F7/123 ,  A61B2018/00011 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44

摘要： A system for controlling patient temperature uses a central venous line catheter having axially spaced distal and proximal heat exchange balloons. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient, and with additional lumens for communicating heat exchange fluid to the balloons. Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.

摘要翻译： 用于控制患者体温的系统使用具有轴向间隔开的远端和近端热交换球囊的中心静脉导管导管。 中心静脉导管设置有一个或多个腔，用于提供对患者的中央血液供应的通路，以及用于将热交换流体传送到气囊的附加腔。 热交换流体温度通过反馈回路来控制，其中感测患者温度并用于控制包括与热交换流体热交换关系的加热装置和/或冷却装置的温度控制单元。 管组在中央静脉管路和温度控制单元之间输送热交换流体，其中泵用于将流体循环在系统中的封闭流体回路中。

公开(公告)号：US6027461A

公开(公告)日：2000-02-22

申请号：US541147

申请日：1995-10-11

申请人： Blair D. Walker ,  Scott M. Evans

发明人： Blair D. Walker ,  Scott M. Evans

IPC分类号： A61M25/01 ,  A61M25/00 ,  A61M25/098 ,  A61B5/00

CPC分类号： A61M25/0009 ,  A61M25/09 ,  A61M2025/09083 ,  A61M2025/09091 ,  A61M2025/091 ,  A61M2025/09166 ,  A61M25/0052

摘要： An infusion guidewire that can be used either as a guidewire or an infusion catheter having an integral, tapered core wire within an infusion lumen formed of the aligned lumens of the conduit of a proximal connector housing, a proximal inner sheath in a proximal guidewire portion and a distal coil wire in a distal guidewire portion. The core wire proximal end is attached to the connector housing, and the core wire distal end is connected to the distal end of the distal wire coil. An outer sheath is attached to the connector housing and formed over the proximal inner sheath and the distal wire coil. A plurality of infusion side holes are formed in a distal infusion segment of the outer sheath in fluid communication with the infusion lumen. At the junction of the proximal inner sheath and the distal wire coil, a radiopaque wire coil of a material having a higher radiopacity than the distal wire coil is formed into a plurality of radiopaque wire coil turns of substantially the same pitch, inner lumen diameter and outer diameter as the distal wire coil. The radiopaque wire coil turns are wound into spacings between adjacent turns of the proximal wire coil such that the wire coils and the inner coil lumens are substantially co-axially aligned and maintained in alignment by the inner and outer sheathes.

摘要翻译： 输注导丝，其可以用作导线或输注导管，其具有在输注内腔内的整体的锥形芯线，所述输注内腔由近端连接器壳体的导管的对准内腔形成，近端导丝部分中的近侧内护套，以及 在远端导丝部分中的远端线圈线。 芯线近端附接到连接器壳体，并且芯线远端连接到远端线圈的远端。 外护套附接到连接器壳体并形成在近侧内护套和远端线圈上。 在外护套的远端输注段中形成有多个输注侧孔，其与输液腔液体连通。 在近侧内护套和远端线圈的接合处，具有比远端线圈线圈更高的射线不透性的材料的不透射线线圈被形成为具有基本上相同的间距，内腔直径的多个不透射线的线圈匝 外径为远端线圈。 不透射线的线圈匝被缠绕在近端线圈的相邻匝之间的间隔中，使得线圈线圈和内线圈腔体基本上同轴对准并且通过内护套和外护套保持对准。

公开(公告)号：US08109894B2

公开(公告)日：2012-02-07

申请号：US13021542

申请日：2011-02-04

申请人： Wayne A. Noda ,  Mike L. Jones ,  Scott M. Evans ,  Blair D. Walker ,  William J. Worthen ,  Yves Pierre Gobin

发明人： Wayne A. Noda ,  Mike L. Jones ,  Scott M. Evans ,  Blair D. Walker ,  William J. Worthen ,  Yves Pierre Gobin

IPC分类号： A61M37/00

CPC分类号： A61F7/12 ,  A61B2018/00011 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44 ,  A61M25/0009 ,  A61M25/1011

摘要： A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.

公开(公告)号：US20110130812A1

公开(公告)日：2011-06-02

申请号：US13021559

申请日：2011-02-04

申请人： WAYNE A. NODA ,  Mike L. Jones ,  Scott M. Evans ,  Blair D. Walker ,  William J. Worchen ,  Yves Pierre Gobin

发明人： WAYNE A. NODA ,  Mike L. Jones ,  Scott M. Evans ,  Blair D. Walker ,  William J. Worchen ,  Yves Pierre Gobin

IPC分类号： A61F7/12

CPC分类号： A61F7/12 ,  A61B2018/00011 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44 ,  A61M25/0009 ,  A61M25/1011

摘要： A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.

公开(公告)号：US07857781B2

公开(公告)日：2010-12-28

申请号：US11129980

申请日：2005-05-16

申请人： Wayne A. Noda ,  Mike L. Jones ,  Scott M. Evans ,  Blair D. Walker ,  William J. Worthen ,  Yves Pierre Gobin

发明人： Wayne A. Noda ,  Mike L. Jones ,  Scott M. Evans ,  Blair D. Walker ,  William J. Worthen ,  Yves Pierre Gobin

IPC分类号： A61M37/00

CPC分类号： A61F7/12 ,  A61B2018/00011 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44 ,  A61M25/0009 ,  A61M25/1011

摘要： A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.

摘要翻译： 导管适于与诸如血管的体导管中流动的体液（例如血液）进行热交换。 导管包括设置在其远端处具有热交换区域的轴。 该区域可以包括中空纤维，其适于接收远离冷却的热交换流体，优选地在与体液相反的方向上流动。 中空纤维增强了接触的表面积，以及两种热交换流体和体液的混合。 导管可以定位成在身体的选择性区域产生低体温，或者定位成系统地冷却整个身体系统。

公开(公告)号：US06893419B2

公开(公告)日：2005-05-17

申请号：US09946835

申请日：2001-09-04

申请人： Wayne A. Noda ,  Mike L. Jones ,  Scott M. Evans ,  Blair D. Walker ,  William J. Worthen ,  Yves Pierre Gobin

发明人： Wayne A. Noda ,  Mike L. Jones ,  Scott M. Evans ,  Blair D. Walker ,  William J. Worthen ,  Yves Pierre Gobin

IPC分类号： A61M25/00 ,  A61B18/00 ,  A61F2/958 ,  A61F7/00 ,  A61F7/12 ,  A61M1/36 ,  A61M5/44 ,  A61P7/12 ,  A61B18/04 ,  A61M3/00 ,  H05B7/12

CPC分类号： A61F7/12 ,  A61B2018/00011 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44 ,  A61M25/0009 ,  A61M25/1011

摘要： A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.

摘要翻译： 导管适于与诸如血管的体导管中流动的体液（例如血液）进行热交换。 导管包括设置在其远端处具有热交换区域的轴。 该区域可以包括中空纤维，其适于接收远离冷却的热交换流体，优选地在与体液相反的方向上流动。 中空纤维增强了接触的表面积，以及两种热交换流体和体液的混合。 导管可以定位成在身体的选择性区域产生低体温，或者定位成系统地冷却整个身体系统。

公开(公告)号：US06620131B2

公开(公告)日：2003-09-16

申请号：US09927942

申请日：2001-08-10

申请人： Nora Tran Pham ,  Lynn M. Shimada ,  Scott M. Evans ,  Blair D. Walker

发明人： Nora Tran Pham ,  Lynn M. Shimada ,  Scott M. Evans ,  Blair D. Walker

IPC分类号： A61F712

CPC分类号： A61F7/123 ,  A61B2018/00011 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44

摘要： A system for controlling patient temperature uses a central venous line catheter having axially spaced distal and proximal heat exchange balloons. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient, and with additional lumens for communicating heat exchange fluid to the balloons. Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.

公开(公告)号：US06529775B2

公开(公告)日：2003-03-04

申请号：US09761069

申请日：2001-01-16

申请人： Mark Evan Whitebook ,  Blair D. Walker ,  Scott M. Evans ,  Lynn M. Shimada

发明人： Mark Evan Whitebook ,  Blair D. Walker ,  Scott M. Evans ,  Lynn M. Shimada

IPC分类号： A61F200

CPC分类号： A61M25/0017 ,  A61B18/1492 ,  A61B2017/00084 ,  A61F7/12 ,  A61F2007/126

摘要： An indwelling RF catheter achieves warming of patients by dielectric heating of blood or other bodily fluids. In one example, the catheter is deployed in a suitable blood vessel, such as the inferior vena cava. The catheter design includes an emitter structure electrically coupled to an RF generator, which provides a source of RF power. The emitter structure, distally located upon the catheter, administers electromagnetic radiation to the blood within the patient, thereby creating heat due to the dielectric qualities of blood. As blood heated by the indwelling RF catheter courses through the patient's body, the patient's body is systemically warmed, raising the body core temperature.

公开(公告)号：US06450990B1

公开(公告)日：2002-09-17

申请号：US09294080

申请日：1999-04-19

申请人： Blair D. Walker ,  Scott M. Evans ,  David P. Balding ,  Gregg Hallam ,  Lynn M. Shimada

发明人： Blair D. Walker ,  Scott M. Evans ,  David P. Balding ,  Gregg Hallam ,  Lynn M. Shimada

IPC分类号： A61F712

CPC分类号： A61F7/123 ,  A61B2018/00011 ,  A61F7/12 ,  A61F2007/0054 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44 ,  A61M25/00 ,  A61M25/0009 ,  A61M2205/36

摘要： A catheter using multiple hollow fibers to carry a heating/cooling fluid employs fiber spreading features to improve heat transfer and help prevent clotting of body fluids within which the catheter is immersed. The catheter includes a length of outer tube surrounding an inner tube. The inner tube conveys fluids in one direction, and the passageway between inner and outer tubes conveys fluids in the opposite direction. The inner and outer tubes have proximal distal ends. The distal end is closed, but the proximal end is open to permit introduction of a heating or cooling fluid into the inner tube, and withdrawal of the fluid from the passageway between the inner and outer tubes. At the tubes' distal end resides a proximal fluid transfer housing coupled to multiple hollow heat exchange fibers. The distal ends of these fibers may be commonly connected to a distal fluid transfer housing and optional reservoir, which cooperatively return fluid to the passageway between inner and outer tubes. In another embodiment, each fiber includes both outflowing and return lumens, enabling the fibers' distal ends to freely move about. In another embodiment, each fiber proceeds outward from the proximal fluid transfer housing, and returns back to form a loop. In each different embodiment, the invention includes one or more actuating structures to spread the fibers. The actuating structure may include, for example, fiber shaping, a retractable spreading member, elastic bias built into the fibers, etc.

摘要翻译： 使用多个中空纤维携带加热/冷却流体的导管使用纤维铺展特征来改善热传递并有助于防止导管浸入其中的体液的凝结。 导管包括围绕内管的一段长度的外管。 内管沿一个方向输送流体，内管和外管之间的通道沿相反方向输送流体。 内管和外管具有近端远端。 远端是封闭的，但是近端是敞开的，以允许将加热或冷却流体引入内管，并且将流体从内管和外管之间的通道中取出。 在管的远端存在耦合到多个中空热交换纤维的近端流体转移壳体。 这些纤维的远端可以通常连接到远端流体传送壳体和任选的储存器，其将流体协作地返回到内管和外管之间的通道。 在另一个实施例中，每个纤维包括流出和回流腔两者，使纤维的远端能够自由移动。 在另一个实施例中，每个纤维从近端流体转移壳体向外进入，并返回以形成环。 在每个不同的实施例中，本发明包括一个或多个驱动结构以扩展纤维。 致动结构可以包括例如纤维成型，可伸缩铺展件，内置在纤维中的弹性偏置等

公开(公告)号：US06338727B1

公开(公告)日：2002-01-15

申请号：US09133813

申请日：1998-08-13

申请人： Wayne A. Noda ,  Mike L. Jones ,  Scott M. Evans ,  Blair D. Walker ,  William J. Worthen ,  Yves Pierre Gobin

发明人： Wayne A. Noda ,  Mike L. Jones ,  Scott M. Evans ,  Blair D. Walker ,  William J. Worthen ,  Yves Pierre Gobin

IPC分类号： A61F712

CPC分类号： A61F7/12 ,  A61B2018/00011 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44 ,  A61M25/0009 ,  A61M25/1011

摘要： A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.

摘要翻译： 导管适于与诸如血管的体导管中流动的体液（例如血液）进行热交换。 导管包括设置在其远端处具有热交换区域的轴。 该区域可以包括中空纤维，其适于接收远离冷却的热交换流体，优选地在与体液相反的方向上流动。 中空纤维增强了接触的表面积，以及两种热交换流体和体液的混合。 导管可以定位成在身体的选择性区域产生低体温，或者定位成系统地冷却整个身体系统。