公开(公告)号：US08907094B2

公开(公告)日：2014-12-09

申请号：US13708324

申请日：2012-12-07

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Monique Bodil Van Niel ,  Nicholas Charles Ray ,  Lilian Alcaraz ,  Terry Aaron Panchal ,  Andrew Stephen Robert Jennings ,  Elisabetta Armani ,  Andrew Peter Cridland ,  Christopher Hurley

IPC: A61K31/553 ,  C07D471/02 ,  C07D401/12 ,  C07D471/04 ,  C07D403/12 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07C53/06 ,  C07D231/40 ,  C07D401/12 ,  C07D403/12 ,  C07D487/08 ,  C07D498/08 ,  C07D519/00

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract translation: 式（I）化合物及其药学上可接受的盐：其中R2，W，A，Y和R1如说明书中所定义，是p38 MAPK抑制剂，并且可用作抗炎剂， 呼吸道疾病