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公开(公告)号：US09802919B1
公开(公告)日：2017-10-31
申请号：US15606313
申请日：2017-05-26
发明人： Jonathan Mark Sutton , Robert Andrew Heald , Andrew Stephen Robert Jennings , Carmelida Capaldi , Elisabetta Armani
IPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D413/14 , C07D471/04 , C07D417/14 , A61K31/4178 , A61K31/4155 , A61K31/4196 , A61K31/454 , C07C309/29
CPC分类号： C07D403/04 , C07C309/29 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for the treatment of disease or conditions in which HNE is implicated.
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公开(公告)号：US09181242B2
公开(公告)日：2015-11-10
申请号：US14296794
申请日：2014-06-05
IPC分类号： C07D211/40 , C07D471/04 , C07C53/06 , C07D519/00
CPC分类号： C07D471/04 , C07C53/06 , C07D519/00
摘要： This invention relates to compounds and compositions that are p38 MAPK inhibitors, useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
摘要翻译： 本发明涉及作为p38MAPK抑制剂的化合物和组合物，其用作治疗特别是呼吸道疾病的抗炎剂。
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公开(公告)号：US09029373B2
公开(公告)日：2015-05-12
申请号：US14451600
申请日：2014-08-05
发明人： Monique Bodil Van Niel , Nicholas Charles Ray , Andrew Peter Cridland , Christopher Hurley , Lilian Alcaraz , Terry Aaron Panchal , Andrew Stephen Robert Jennings , Elisabetta Armani
IPC分类号： A61K31/5377 , C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of formula (I): wherein R2, W, A, Y, and R1 are as defined in the specification, and pharmaceutically acceptable salts thereof, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
摘要翻译： 式（I）化合物：其中R2，W，A，Y和R1如说明书中所定义，及其药学上可接受的盐是p38 MAPK抑制剂，可用作抗炎剂，用于治疗 尤其是呼吸道疾病。
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公开(公告)号：US09139584B2
公开(公告)日：2015-09-22
申请号：US14513663
申请日：2014-10-14
发明人： Monique Bodil Van Niel , Nicholas Charles Ray , Lilian Alcaraz , Terry Aaron Panchal , Andrew Stephen Robert Jennings , Elisabetta Armani , Andrew Peter Cridland , Christopher Hurley
IPC分类号： A61K31/553 , C07D513/02 , C07D471/04 , C07D401/12 , C07D403/12 , C07D519/00 , C07D487/08 , C07D498/08 , C07C53/06
CPC分类号： C07D471/04 , C07C53/06 , C07D231/40 , C07D401/12 , C07D403/12 , C07D487/08 , C07D498/08 , C07D519/00
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
摘要翻译： 式（I）化合物及其药学上可接受的盐：其中R2，W，A，Y和R1如说明书中所定义，是p38 MAPK抑制剂，并且可用作抗炎剂， 呼吸道疾病
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公开(公告)号：US20150080375A1
公开(公告)日：2015-03-19
申请号：US14513663
申请日：2014-10-14
发明人： Monique Bodil Van Niel , Nicholas Charles Ray , Lilian Alcaraz , Terry Aaron Panchal , Andrew Stephen Robert Jennings , Elisabetta Armani , Andrew Peter Cridland , Christopher Hurley
IPC分类号： C07D471/04 , C07D401/12 , C07D403/12 , C07C53/06
CPC分类号： C07D471/04 , C07C53/06 , C07D231/40 , C07D401/12 , C07D403/12 , C07D487/08 , C07D498/08 , C07D519/00
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
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公开(公告)号：US20130150343A1
公开(公告)日：2013-06-13
申请号：US13708324
申请日：2012-12-07
发明人： Monique Bodil VAN NIEL , Nicholas Charles Ray , Lilian Alcaraz , Terry Aaron Panchal , Andrew Stephen Robert Jennings , Elisabetta Armani , Andrew Peter Cridland , Christopher Hurley
IPC分类号： C07D471/04 , C07D403/12 , C07D401/12
CPC分类号： C07D471/04 , C07C53/06 , C07D231/40 , C07D401/12 , C07D403/12 , C07D487/08 , C07D498/08 , C07D519/00
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
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公开(公告)号：US20180009787A1
公开(公告)日：2018-01-11
申请号：US15712366
申请日：2017-09-22
发明人： Jonathan Mark SUTTON , Robert Andrew Heald , Andrew Stephen Robert Jennings , Carmelida Capaldi , Elisabetta Armani
IPC分类号： C07D403/04 , C07D417/14 , C07D413/14 , C07D403/14 , C07D401/14 , C07D471/04 , C07C309/29
CPC分类号： C07D403/04 , C07C309/29 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for the treatment of disease or conditions in which HNE is implicated
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![Derivatives of [1, 2, 4] triazolo [4, 3-a] pyridine as P38—MAP kinase inhibitors](/abs-image/US/2017/02/21/US09573949B2/abs.jpg.150x150.jpg)
8.发明授权Derivatives of [1, 2, 4] triazolo [4, 3-a] pyridine as P38—MAP kinase inhibitors 有权[1,2,4]三唑并[4,3-a]吡啶的衍生物作为P38-MAP激酶抑制剂公开(公告)号：US09573949B2
公开(公告)日：2017-02-21
申请号：US14895718
申请日：2013-06-06
发明人： Lilian Alcaraz , Terry Aaron Panchal , Andrew Stephen Robert Jennings , Andrew Peter Cridland , Christopher Hurley
IPC分类号： A61K31/437 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Mitogen activated protein kinase (MAPK) inhibitors disclosed herein are useful for the treatment of diseases of the respiratory tract, such as chronic eosinophilic pneumonia, asthma, COPD, adult respiratory distress syndrome (ARDS), exacerbation of airways hyper-reactivity consequent to other drug therapy, and airways disease that is associated with pulmonary hypertension.
摘要翻译： 本文公开的丝裂原活化蛋白激酶（MAPK）抑制剂可用于治疗呼吸道疾病，如慢性嗜酸粒细胞性肺炎，哮喘，COPD，成人呼吸窘迫综合征（ARDS），气道高反应性加剧其他药物 治疗和与肺动脉高压相关的气道疾病。
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公开(公告)号：US20150344475A1
公开(公告)日：2015-12-03
申请号：US14819722
申请日：2015-08-06
发明人： Monique Bodil VAN NIEL , Nicholas Charles Ray , Lilian Alcaraz , Terry Aaron Panchal , Andrew Stephen Robert Jennings , Elisabetta Armani , Andrew Peter Cridland , Christopher Hurley
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07C53/06 , C07D231/40 , C07D401/12 , C07D403/12 , C07D487/08 , C07D498/08 , C07D519/00
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
摘要翻译： 式（I）化合物及其药学上可接受的盐：其中R2，W，A，Y和R1如说明书中所定义，是p38 MAPK抑制剂，并且可用作抗炎剂， 呼吸道疾病
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公开(公告)号：US20140323470A1
公开(公告)日：2014-10-30
申请号：US14330145
申请日：2014-07-14
发明人： Monique Bodil VAN NIEL , Nicholas Charles Ray , Lilian Alcaraz , Terry Aaron Panchal , Andrew Stephen Robert Jennings , Elisabetta Armani , Andrew Peter Cridland , Christopher Hurley
IPC分类号： C07D498/08 , C07D487/08 , C07D403/12 , C07D471/04 , C07D401/12
CPC分类号： C07D471/04 , C07C53/06 , C07D231/40 , C07D401/12 , C07D403/12 , C07D487/08 , C07D498/08 , C07D519/00
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
摘要翻译： 式（I）化合物及其药学上可接受的盐：其中R2，W，A，Y和R1如说明书中所定义，是p38MAPK抑制剂，并且可用作抗炎剂， 呼吸道疾病
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