公开(公告)号：US20210401574A1

公开(公告)日：2021-12-30

申请号：US17468414

申请日：2021-09-07

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24

Abstract: A delivery assembly includes a prosthetic device, a catheter shaft, a release wire, a first line, and a second line. The prosthetic device has a first arm and a second arm. The release wire extends through the catheter shaft. The first line includes a first loop. The first line extends from the catheter shaft, through the first arm of the prosthetic device, and to the release wire, where the release wire extends through the first loop. The second line includes a second loop. The second line extends from the catheter shaft, through the second arm of the prosthetic device, and to the release wire, where the release wire extends through the second loop.

公开(公告)号：US11116632B2

公开(公告)日：2021-09-14

申请号：US17076705

申请日：2020-10-21

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: A handle assembly for a transvascular prosthetic heart valve delivery apparatus including a handle housing, a main shaft extending distally from the handle housing, the main shaft configured to be coupled to a distal valve sheath that is configured to retain a prosthetic heart valve in a radially compressed state within the valve sheath, a screw shaft, a control knob that is rotatable relative to the handle housing and the screw shaft, a screw engagement latch that is adjustable between an engaged position and a disengaged position. In the engaged position, the latch can couple the control knob to the screw shaft such that rotation of the control knob relative to the handle housing causes the main shaft to move axially relative to the handle housing. In the disengaged position, the latch can decouple the control knob from the screw shaft such that the main shaft can move axially relative to the handle housing without rotation of the control knob.

公开(公告)号：US10945839B2

公开(公告)日：2021-03-16

申请号：US15918240

申请日：2018-03-12

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: Embodiments of the present disclosure provide a prosthetic heart valve usable with a heart valve delivery apparatus for delivery of the prosthetic heart valve to a native valve site via the human vasculature. In one embodiment, a self-expanding valve comprises an expandable stent that is shaped to maintain the valve in the aortic annulus against axial without anchors or retaining devices that engage the surrounding tissue. The prosthetic heart valve can have a curved shape that tapers inwardly from the inflow end to a reduced diameter section, increases in diameter from the reduced diameter section to an intermediate section, and then tapers from the intermediate section to the outflow end.

公开(公告)号：US20200375738A1

公开(公告)日：2020-12-03

申请号：US16997890

申请日：2020-08-19

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24

Abstract: An assembly for transvascular replacement of a native aortic heart valve can have a radially collapsible and self-expandable prosthetic heart valve and a delivery apparatus. The valve can have an annular metal frame made of a shape-memory material with a plurality of posts extending from an end portion of the frame. The delivery apparatus can have a shaft comprising a valve connection portion that is releasably coupled to the posts of the valve. The valve connection portion can have a plurality of discrete radially facing recesses that receive the posts. The delivery apparatus can have a delivery sheath that is positioned around the prosthetic heart valve and the valve connection portion of the shaft to maintain the prosthetic heart valve in a radially compressed state and maintain the posts within the recesses. The delivery apparatus can cause relative axial motion between the delivery sheath and the valve.

公开(公告)号：US20200375737A1

公开(公告)日：2020-12-03

申请号：US16997866

申请日：2020-08-19

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24

Abstract: An assembly for replacing a native heart valve can have a prosthetic heart valve with an annular metal frame made from shape-memory material and a valve member disposed in an interior of the metal frame. The assembly can have a delivery apparatus with a handle, a shaft with a proximal end portion and a distal end portion. The proximal end portion can be coupled to the handle and the distal end portion can be releasably coupled to the prosthetic heart valve. The delivery apparatus can also have a delivery sheath and a hydraulic power source operatively connected to the delivery sheath. The prosthetic heart valve can be positioned within the delivery sheath in a radially compressed state. The hydraulic power source can be configured to move the delivery sheath longitudinally relative to the valve to allow the valve to self-expand from the radially compressed state to a radially expanded state.

公开(公告)号：US10799361B2

公开(公告)日：2020-10-13

申请号：US16803455

申请日：2020-02-27

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan Otto Solem ,  David Alon

IPC: A61F2/24

Abstract: A method of treating a defective mitral valve includes inserting a delivery catheter through a small incision in a patient's groin, wherein the delivery catheter has a prosthetic device positioned along a distal end thereof. The prosthetic device includes an insert member and an anchoring member, wherein the insert member is made from a shape memory material and is surrounded by a biocompatible fabric outer layer. The insert member is positioned within a mitral valve and self-expands in a gap between the native leaflets. The anchoring member is attached to surrounding tissue. After deployment of the prosthetic device, the native leaflets of the mitral valve form a tight seal against the biocompatible fabric outer layer and the insert member fills the gap between the native leaflets of the mitral valve for preventing regurgitation during ventricular systole.

公开(公告)号：US20180228607A1

公开(公告)日：2018-08-16

申请号：US15954193

申请日：2018-04-16

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: Methods for delivering a prosthetic valve comprise introducing the prosthetic heart valve into a body of a patient. The prosthetic valve is mounted within a delivery sheath of a delivery apparatus in a radially compressed state. The prosthetic valve is advanced through the body to a delivery location. A motor is actuated to cause the delivery sheath to retract to expose the prosthetic valve and the prosthetic valve expands to a radially expanded state at the delivery location. The methods can also include releasing the prosthetic valve from the delivery apparatus and removing the delivery apparatus from the patient.

公开(公告)号：US20250161045A1

公开(公告)日：2025-05-22

申请号：US19027973

申请日：2025-01-17

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: Prosthetic valve delivery assemblies including a prosthetic heart valve and a delivery apparatus. The prosthetic heart valve includes a frame having posts extending from a terminal outflow end of the frame and a valve structure disposed within the frame. The delivery apparatus includes an inner shaft including a valve connection portion having recesses configured to receive the posts of the frame of the prosthetic heart valve, an outer shaft including a valve sheath for retaining the prosthetic valve in a radially compressed state and retaining the posts within the recesses, and a handle including a control knob for moving the valve sheath proximally and distally relative to the handle. The control knob is seated within the handle housing such that the housing partially covers a circumferentially extending outer surface of the control knob.

公开(公告)号：US12186183B2

公开(公告)日：2025-01-07

申请号：US17485154

申请日：2021-09-24

Applicant: Edwards Lifesciences Corporation

Inventor： Michael J. Popp ,  David Alon ,  Jun Liu ,  Luca Pesce ,  Mohammad Jafari

IPC: A61F2/24 ,  A61F2/00 ,  A61F2/915 ,  A61F2/95 ,  A61F2/966 ,  A61M25/00

Abstract: Certain embodiments of the present disclosure provide a prosthetic valve (e.g., prosthetic heart valve) and a valve delivery apparatus for delivery of the prosthetic valve to a native valve site via the human vasculature. The delivery apparatus is particularly suited for advancing a prosthetic heart valve through the aorta (i.e., in a retrograde approach) for replacing a diseased native aortic valve. The delivery apparatus in particular embodiments is configured to deploy a prosthetic valve from a delivery sheath in a precise and controlled manner at the target location within the body.

公开(公告)号：US20220023033A1

公开(公告)日：2022-01-27

申请号：US17496649

申请日：2021-10-07

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan Otto Solem ,  David Alon

IPC: A61F2/24

Abstract: A method of treating a defective heart valve includes inserting a delivery catheter through a small incision in a patient's groin, wherein the delivery catheter has a prosthetic device positioned along a distal end. The prosthetic device includes an insert member and an anchoring member. The insert member self-expands to plug gaps between leaflets of the heart valve. The anchoring member is preferably a stent connected to the insert member by at least one elongate member. The stent is deployed within an adjacent blood vessel for anchoring the insert member. After deployment of the prosthetic device, the leaflets of the heart valve form a tight seal against the insert member for preventing regurgitation when the leaflets are closed and wherein blood passes through the insert member when the leaflets are open.