公开(公告)号：US11690718B2

公开(公告)日：2023-07-04

申请号：US17158458

申请日：2021-01-26

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2/9517 ,  A61F2/9522 ,  A61F2002/9528 ,  A61F2002/9534 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/001 ,  A61F2230/0054 ,  A61F2230/0076 ,  A61F2250/0039

Abstract: A delivery assembly includes a prosthetic device, a catheter shaft, a release wire, a first line, and a second line. The prosthetic device has a first arm and a second arm. The release wire extends through the catheter shaft. The first line includes a first loop. The first line extends from the catheter shaft, through the first arm of the prosthetic device, and to the release wire, where the release wire extends through the first loop. The second line includes a second loop. The second line extends from the catheter shaft, through the second arm of the prosthetic device, and to the release wire, where the release wire extends through the second loop.

公开(公告)号：US10952848B2

公开(公告)日：2021-03-23

申请号：US15953991

申请日：2018-04-16

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: Embodiments of the present disclosure provide methods of loading a prosthetic heart valve within a delivery apparatus such that it can be used for delivery of the prosthetic heart valve to a native valve site via the human vasculature. The methods can include attaching the prosthetic heart valve to a valve-retaining mechanism at a distal end of the catheter and causing a torque shaft of the delivery apparatus to rotate relative to the catheter, wherein the torque shaft extends within the catheter and is coupled to the valve delivery sheath. Rotation of the torque shaft relative to the catheter can cause relative longitudinal movement between the valve sheath and the prosthetic heart valve such that the prosthetic heart valve is covered by the valve sheath.

公开(公告)号：US10722355B2

公开(公告)日：2020-07-28

申请号：US15729986

申请日：2017-10-11

Applicant: Edwards Lifesciences Corporation

Inventor： Stanton J. Rowe ,  Francesco Maisano ,  Oded Meiri

IPC: A61F2/24 ,  A61B17/04 ,  A61B17/32 ,  A61M25/10 ,  A61M25/00

Abstract: Prosthetic valve systems for replacing a native valve exhibiting regurgitation include a support structure and a transcatheter heart valve (THV) that is separate from the support structure. The support structure can be configured to be positioned such that it extends annularly around the native valve leaflets. After the support structure is deployed around the native valve leaflets, the THV can be expanded within the support structure such that the native valve leaflets are engaged between the support structure and the THV.

公开(公告)号：US20190380833A1

公开(公告)日：2019-12-19

申请号：US16554014

申请日：2019-08-28

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

IPC: A61F2/24

Abstract: A prosthetic heart valve includes a frame, a valvular structure coupled to the frame, and a sealing member coupled to the frame. The frame has inflow and outflow ends and a lumen extending therebetween. The frame includes struts that form cells, and the cells are arranged in three rows. The frame is radially expandable from a collapsed state to an expanded state. The valvular structure includes a plurality of leaflets configured to allow blood flow through the lumen of the frame from the inflow end to the outflow end and to block blood flow through the lumen of the frame from the outflow end to the inflow end. The sealing skirt extends from an intermediate location of the frame disposed between the inflow and outflow ends to the inflow end of the frame. The sealing skirt covers two rows of cells to block blood flow through the cells.

公开(公告)号：US20180318074A1

公开(公告)日：2018-11-08

申请号：US16039215

申请日：2018-07-18

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

IPC: A61F2/24

Abstract: A prosthetic heart valve includes a frame, a valve member, and a sealing member. The frame is expandable from a collapsed state to an expanded state. The frame has inflow and outflow ends, a lumen extending between the ends, and a plurality of struts defining a plurality of cells. The valve member is disposed within the lumen of the frame and is movable between open and closed configurations. The sealing member is mounted inside of the frame. When the frame is in the expanded state and the valve member is in the closed configuration, portions of the sealing member can protrude outwardly through the cells of the frame and extend beyond an exterior surface of the struts of the frame.

公开(公告)号：US10076411B2

公开(公告)日：2018-09-18

申请号：US15246234

申请日：2016-08-24

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2436 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0065 ,  A61F2250/0069

Abstract: The present disclosure is directed to embodiments of catheter-based prosthetic heart valves, and in particular, prosthetic heart valves having sealing devices configured to seal the interface between the prosthetic valve and the surrounding tissue of the native annulus in which the prosthetic valve is implanted. In one embodiment, a prosthetic heart valve includes an annular sealing member that can be placed in a delivery orientation extending axially away from one end of the valve when the valve is in a radially compressed state. When the valve is expanded, the expansion of the frame causes the sealing member to be pulled to an operative orientation covering a portion of the frame. The present disclosure also discloses new mechanisms and techniques for mounting valve leaflets to a frame of a prosthetic heart valve.

公开(公告)号：US11918461B2

公开(公告)日：2024-03-05

申请号：US18317771

申请日：2023-05-15

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Oded Meiri ,  Tamir S. Levi ,  Ofir Witzman

IPC: A61B17/128 ,  A61B17/04 ,  A61B17/12 ,  A61B17/122 ,  A61F2/24

CPC classification number: A61F2/2409 ,  A61B17/0487 ,  A61B17/12013 ,  A61B17/122 ,  A61B17/1227 ,  A61B17/1285 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2433 ,  A61F2/2436 ,  A61B2017/0488 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/006

Abstract: A method of treating a deficient native mitral valve of a heart of a patient includes advancing a steerable, first catheter through the patient's vasculature, advancing the distal end portion of the first catheter into the heart to position the distal end portion of the first catheter adjacent the native mitral valve, adjusting the curvature of the distal end portion of the first catheter to form a first curve, advancing a distal end portion of a second catheter from a distal end of the first catheter, wherein the distal end portion of the second catheter is pre-shaped to form a second curve when advanced from the first catheter, and deploying a wire from the second catheter such that the wire extends around native leaflets of the native mitral valve.

公开(公告)号：US11730597B2

公开(公告)日：2023-08-22

申请号：US18102024

申请日：2023-01-26

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2/9517 ,  A61F2/9522 ,  A61F2002/9528 ,  A61F2002/9534 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/001 ,  A61F2230/0054 ,  A61F2230/0076 ,  A61F2250/0039

Abstract: An assembly for replacement of a native aortic heart valve includes a radially collapsible prosthetic heart valve and a delivery apparatus. The prosthetic heart valve includes an annular frame with attachment posts, wherein each of the posts has an axial post portion and a transverse post portion having a greater circumferential dimension than the axial post portion. The delivery apparatus includes an inner shaft with a valve connection portion for releasably coupling to the attachment posts and an outer shaft having a sheath for maintaining the prosthetic heart valve in a radially compressed state. Rotation of a control knob on a handle causes the sheath to retract for uncovering a portion of the prosthetic heart valve. Further rotation of the control knob allows the posts to decouple from the delivery apparatus such that the prosthetic heart valve self-expands to a fully expanded state.

公开(公告)号：US20220079756A1

公开(公告)日：2022-03-17

申请号：US17456355

申请日：2021-11-23

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24

Abstract: Prosthetic heart valves and methods of implantation thereof are disclosed herein. In embodiments, a prosthetic heart valve includes a self-expandable frame configured to support of valve member and comprising a plurality of interconnected strut members forming a mesh structure. An inflow end and outflow end portions of the mesh structure respectively define an inflow terminal end and an outflow terminal end of the frame. A portion of the frame tapers inwardly from the inflow terminal end to form a reduced diameter section. In implementations, the frame increases in diameter from the reduced diameter section to an intermediate section. In implementations, the valve member is secured to the frame at the inflow end portion. In implementations, the frame further comprises a plurality of retaining arms that extend from the outflow terminal end and are configured to engage with a valve retaining mechanism of a delivery apparatus.

公开(公告)号：US11141270B2

公开(公告)日：2021-10-12

申请号：US17185135

申请日：2021-02-25

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: A prosthetic heart valve for replacing a defective aortic valve includes a self-expandable annular frame made of shape-memory material. A one-way valve structure is disposed within an interior of the frame. The frame includes a plurality of posts projecting axially from an outflow end portion of the frame, wherein each of the posts includes an axial post portion and a terminal post portion. The terminal post portions have greater circumferential dimensions than the axial post portions. The terminal post portions are preferably formed with concave inner surfaces and convex outer surfaces for conforming to the shape of a delivery catheter. Each of the posts is shaped for placement within a corresponding recess along a distal end portion of the delivery catheter for ensuring that the prosthetic heart valve remains coupled to the delivery catheter while the prosthetic heart valve is expanded within the defective aortic valve.