公开(公告)号：US20180291014A1

公开(公告)日：2018-10-11

申请号：US15939112

申请日：2018-03-28

Applicant: GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

Inventor： Phillipe BERGERON ,  Kristen BURFORD ,  Sultan CHOWDHURY ,  Christoph Martin DEHNHARDT ,  Thilo FOCKEN ,  Michael Edward GRIMWOOD ,  Abid HASAN ,  Kwong Wah LAI ,  Zhiguo LIU ,  Steven MCKERRALL ,  Teresa Phuongtram NGUYEN ,  Brian SAFINA ,  Daniel SUTHERLIN ,  Tao WANG

IPC: C07D417/12 ,  C07D417/14 ,  C07D401/12 ,  C07D405/14 ,  C07D491/107 ,  A61P17/04

Abstract: The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20160340309A1

公开(公告)日：2016-11-24

申请号：US15161085

申请日：2016-05-20

Applicant: GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

Inventor： Sultan CHOWDHURY ,  Christoph Martin DEHNHARDT ,  Abid HASAN ,  Ivan William HEMEON ,  Qi JIA ,  Jun LI ,  Zhiguo LIU ,  Daniel F. ORTWINE ,  Brian SAFINA ,  Daniel SUTHERLIN ,  Shaoyi SUN ,  Andrew D. WHITE ,  Wei GONG ,  Alla Yurevna ZENOVA ,  Jiuxiang ZHU

IPC: C07D211/22 ,  C07D211/34 ,  C07D405/08 ,  C07D401/04 ,  C07D401/08 ,  C07D211/42 ,  C07D221/20 ,  C07D211/48 ,  C07D401/12

CPC classification number: C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/42 ,  C07D211/48 ,  C07D211/62 ,  C07D221/20 ,  C07D401/04 ,  C07D401/08 ,  C07D401/12 ,  C07D405/08

Abstract: The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract translation: 本发明提供了具有钠通道活性的化合物（例如，NaV1.7）抑制剂，其可用于治疗钠通道介导的疾病或病症，例如疼痛，以及与钠通道调停相关的其它疾病和病症，以及 含有这些化合物的组合物和使用这些化合物和组合物的方法。