公开(公告)号：US20240390678A1

公开(公告)日：2024-11-28

申请号：US18790835

申请日：2024-07-31

Applicant: Galvani Bioelectronics Limited

Inventor： Matteo Donega ,  Daniel John Chew ,  Isha Gupta

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/20

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.

公开(公告)号：US20230285752A1

公开(公告)日：2023-09-14

申请号：US18141045

申请日：2023-04-28

Applicant: Galvani Bioelectronics Limited

Inventor： Daniel John Chew ,  Matteo Donega ,  Isha Gupta

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/20

CPC classification number: A61N1/36071 ,  A61N1/0553 ,  A61N1/0556 ,  A61N1/205 ,  A61N1/36135 ,  A61N1/3616 ,  A61N1/36171

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.

公开(公告)号：US11738196B2

公开(公告)日：2023-08-29

申请号：US17872432

申请日：2022-07-25

Applicant: Galvani Bioelectronics Limited

Inventor： Margarita J. Vervoordeldonk ,  Eric Irwin ,  Daniel John Chew ,  Matteo Donega ,  Cindy Cleypool ,  Isha Gupta

IPC: A61N1/00 ,  A61N1/36 ,  A61N1/05 ,  A61N1/08

CPC classification number: A61N1/3606 ,  A61N1/0556 ,  A61N1/3614 ,  A61N1/36135 ,  A61N1/36139 ,  A61N1/36171 ,  A61N1/36178 ,  A61N2001/083

Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.

公开(公告)号：US20220409890A1

公开(公告)日：2022-12-29

申请号：US17872829

申请日：2022-07-25

Applicant: Galvani Bioelectronics Limited

Inventor： Matteo Donega ,  Daniel John Chew ,  Margarita J. Vervoordeldonk ,  Isha Gupta

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/378

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.

公开(公告)号：US11452867B2

公开(公告)日：2022-09-27

申请号：US16955331

申请日：2018-12-20

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Matteo Donega ,  Daniel John Chew ,  Margarita J. Vervoordeldonk ,  Isha Gupta

IPC: A61N1/00 ,  A61N1/05 ,  A61N1/36 ,  A61N1/378

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.

公开(公告)号：US11446502B2

公开(公告)日：2022-09-20

申请号：US16955264

申请日：2018-12-20

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Matteo Donega ,  Daniel John Chew ,  Isha Gupta

IPC: A61N1/36 ,  A61N1/05

Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.