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公开(公告)号：US10183009B2
公开(公告)日：2019-01-22
申请号：US15592013
申请日：2017-05-10
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , F. Anthony Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC: A61K31/40 , C07D471/04
Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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公开(公告)号：US10155764B2
公开(公告)日：2018-12-18
申请号：US15449692
申请日：2017-03-03
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Alexandre Cote , Terry Crawford , Martin Duplessis , Andrew Charles Good , Yves LeBlanc , Steven Magnuson , Christopher G. Nasveschuk , Richard Pastor , Anthony F. Romero , Alexander M. Taylor
IPC: C07D487/04 , C07D403/12 , C07D401/12 , C07D237/32 , C07D471/04 , A61K31/502 , A61K31/5025 , A61K31/5377 , A61K31/55 , C07D237/34 , C07D405/12
Abstract: The present invention relates to methods for treating PCAF and GCN5 mediated disorders using a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein ring A, R1, R3, R4, R5, and each Re have any of the values defined in the specification. Also included are novel compounds of Formula (I) and salts thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20180009805A1
公开(公告)日：2018-01-11
申请号：US15658213
申请日：2017-07-24
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Marc Adler , Daniel J. Burdick , Terry Crawford , Martin Duplessis , Steven R. Magnuson , Christopher G. Nasveschuk , Anthony F. Romero , Yong Tang , Vickie Hsiao-Wei Tsui , Shumei Wang
IPC: C07D471/04 , A61K45/06 , A61K31/506 , A61K31/437 , A61K31/4545 , A61K31/444 , C07D519/00 , A61K31/5377
CPC classification number: C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D519/00
Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein R1-R6 have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of TAF1. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various TAF1-mediated disorders.
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公开(公告)号：US20170342067A1
公开(公告)日：2017-11-30
申请号：US15592017
申请日：2017-05-10
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , Anthony F. Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC: C07D471/04 , A61K45/06 , A61K31/4985 , A61K31/496 , A61K31/4545 , C07D519/00 , A61K31/437
CPC classification number: C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K45/06 , C07D519/00
Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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公开(公告)号：US20170340605A1
公开(公告)日：2017-11-30
申请号：US15592013
申请日：2017-05-10
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , Anthony F. Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC: A61K31/40 , C07D471/04
CPC classification number: A61K31/40 , C07D471/04
Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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Patent Agency Ranking
公开(公告)号：US20170334883A1
公开(公告)日：2017-11-23
申请号：US15449706
申请日：2017-03-03
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Alexandre Cote , Terry Crawford , Martin Duplessis , Andrew Charles Good , Yves LeBlanc , Steven Magnuson , Christopher G. Nasveschuk , Richard Pastor , Anthony F. Romero , Alexander M. Taylor
IPC: C07D403/12 , C07D401/12 , C07D401/04 , C07D253/075 , A61K45/06 , C07D403/04 , A61K31/53
CPC classification number: C07D403/12 , A61K31/53 , A61K45/06 , A61P35/00 , C07D249/12 , C07D253/075 , C07D401/04 , C07D401/12 , C07D403/04
Abstract: The present invention relates to methods for treating PCAF mediated disorders using a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R3-R6, X, and each Re have any of the values defined in the specification. Also included are novel compounds of formula (I) and salts thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20170173026A1
公开(公告)日：2017-06-22
申请号：US15454793
申请日：2017-03-09
Applicant: Genentech, Inc.
Inventor： Huifen Chen , Terry Crawford , Seth F. Harris , Steven R. Magnuson , Chudi Nbdubaku , Lan Wang
IPC: A61K31/519 , A61K31/551 , A61K31/553 , A61K31/5377
CPC classification number: A61K31/519 , A61K31/5377 , A61K31/551 , A61K31/553 , C07D239/94 , C07D239/95 , C07D401/04 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
Abstract: The invention provides a method of inhibiting angiogenesis in a patient by administering a compound of formula (I): wherein R1 R2 and R3 are as defined herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20160296525A1
公开(公告)日：2016-10-13
申请号：US15184310
申请日：2016-06-16
Applicant: Genentech, Inc.
Inventor： Huifen Chen , Terry Crawford , Seth F. Harris , Steven R. Magnuson , Chudi Ndubaku , Lan Wang
IPC: A61K31/519 , A61K31/551 , A61K31/553 , A61K31/5377
CPC classification number: A61K31/519 , A61K31/5377 , A61K31/551 , A61K31/553 , C07D239/94 , C07D239/95 , C07D401/04 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
Abstract: The invention provides a method of treating cancer in a patient by administering a compound of formula (I): wherein R1 R2 and R3 are as defined herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20140343036A1
公开(公告)日：2014-11-20
申请号：US14448941
申请日：2014-07-31
Applicant: Genentech, Inc.
Inventor： Huifen Chen , Terry Crawford , Steven R. Magnuson , Chudi Ndubaku , Lan Wang
IPC: C07D471/04 , C07D401/12 , C07D413/12
CPC classification number: C07D471/04 , C07D217/22 , C07D217/26 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/12
Abstract: The invention provides novel compounds having the general formula: wherein A, R1 and R2 are as described herein, compositions including the compounds and methods of using the compounds.
Abstract translation: 本发明提供具有以下通式的新化合物：其中A，R 1和R 2如本文所述，包括该化合物的组合物和使用该化合物的方法。
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公开(公告)号：US20130324516A1
公开(公告)日：2013-12-05
申请号：US13906626
申请日：2013-05-31
Applicant: Genentech, Inc
Inventor： Huifen Chen , Terry Crawford , Seth F. Harris , Steven R. Magnuson , Chudi Ndubaku , Lan Wang
IPC: C07D471/04 , C07D239/94
CPC classification number: A61K31/519 , A61K31/5377 , A61K31/551 , A61K31/553 , C07D239/94 , C07D239/95 , C07D401/04 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
Abstract: The invention provides novel compounds having the general formula: wherein A, R1, R2 and R3 are as defined herein, compositions including the compounds and methods of using the compounds.
Abstract translation: 本发明提供具有以下通式的新化合物：其中A，R 1，R 2和R 3如本文所定义，包括该化合物的组合物和使用该化合物的方法。
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