公开(公告)号：US20240343740A1

公开(公告)日：2024-10-17

申请号：US18562568

申请日：2022-05-19

申请人： Eli Lilly and Company

发明人： Francisco Javier AGEJAS CHICHARRO ,  Renato Alejandro BAUER ,  Michael Gregory BELL ,  Qi CHEN ,  Graham Robert CUMMING ,  Todd FIELDS ,  Douglas Linn GERNERT ,  Joseph Daniel HO ,  Talbi Abelkader KAOUDI ,  Thierry Jean MASQUELIN ,  Jose Miguel MINGUEZ ORTEGA ,  Julian PRIEGO SOLER ,  Antonio RODRIGUEZ HERGUETA ,  Eric Michael WOERLY

IPC分类号： C07D498/08 ,  A61K31/40 ,  A61K31/444 ,  A61K31/529 ,  C07D498/18 ,  C07D519/00

CPC分类号： C07D498/08 ,  A61K31/40 ,  A61K31/444 ,  A61K31/529 ,  C07D498/18 ,  C07D519/00

摘要： In an embodiment, the present invention provides a compound of the formula: or a pharmaceutically acceptable salt thereof, and methods of using this compound for treating type II diabetes mellitus.

公开(公告)号：US20240343710A1

公开(公告)日：2024-10-17

申请号：US18583024

申请日：2024-02-21

申请人： 1cBio, Inc.

发明人： Jayakanth KANKANALA ,  Jeremy D. PETTIGREW ,  Son Minh PHAM

IPC分类号： C07D401/14 ,  A61K31/439 ,  A61K31/444 ,  A61K31/501 ,  A61K31/5383 ,  A61P31/00 ,  C07D407/14 ,  C07D487/08 ,  C07D487/16 ,  C07D498/16

CPC分类号： C07D401/14 ,  A61K31/439 ,  A61K31/444 ,  A61K31/501 ,  A61K31/5383 ,  A61P31/00 ,  C07D407/14 ,  C07D487/08 ,  C07D487/16 ,  C07D498/16

摘要： The present disclosure relates to compounds of Formula (I):




and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating PARP1 activity and may be used in the treatment of disorders in which PARP1 activity is implicated, such as cancer.

公开(公告)号：US20240336619A1

公开(公告)日：2024-10-10

申请号：US18740233

申请日：2024-06-11

申请人： Karuna Therapeutics, Inc.

发明人： Kevin Matthew Gardinier ,  James Edmund Audia ,  James Monn ,  Jason Myers ,  Nadia M. Ahmad ,  Emanuela Gancia ,  Niall Wagstaff ,  David G. Evans ,  Fabien Jean Ghislain Roussel ,  Elizabeth Anne Skidmore

IPC分类号： C07D487/04 ,  A61K31/437 ,  A61K31/444 ,  C07D519/00

CPC分类号： C07D487/04 ,  A61K31/437 ,  A61K31/444 ,  C07D519/00

摘要： The invention provides substituted tetrahydropyrrolo-pyridinone compounds, pharmaceutical compositions, and their use in treating muscarinic acetylcholine receptor mediated disorders.

公开(公告)号：US20240336615A1

公开(公告)日：2024-10-10

申请号：US18582363

申请日：2024-02-20

申请人： Boehringer Ingelheim Vetmedica GmbH ,  NIHON NOHYAKU CO., LTD.

发明人： Bart Herlé ,  Julien Gagnepain ,  Hannes Fiepko KOOLMAN ,  Alan Long ,  Robin Meier ,  Ikki Yonemura

IPC分类号： C07D487/04 ,  A61K31/444 ,  A61K31/5025 ,  A61P33/14 ,  C07D471/04

CPC分类号： C07D487/04 ,  A61K31/444 ,  A61K31/5025 ,  A61P33/14 ,  C07D471/04

摘要： The present invention relates to cyclopropyl-(hetero)aryl substituted ethylsulfoximine-pyridine derivatives of formulae (I), (Ia) or (Ib)




wherein the variables are as defined in the description and/or in the claims, which can be used as antiparasitic agents for the treatment, prevention and/or control of parasitic infections and/or infestations in/on animals as well as crop protection agents.

公开(公告)号：US12110283B2

公开(公告)日：2024-10-08

申请号：US17372029

申请日：2021-07-09

申请人： VisEn Medical, Inc.

发明人： Kevin Groves ,  Bagna Bao

IPC分类号： C07D401/06 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K49/00 ,  C07D209/14 ,  C07D209/60 ,  C07D401/14 ,  C07D417/14 ,  C09B23/01 ,  C09B23/08 ,  G01N21/64 ,  G01N33/58

CPC分类号： C07D401/06 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/0052 ,  C07D209/14 ,  C07D209/60 ,  C07D401/14 ,  C07D417/14 ,  C09B23/0008 ,  C09B23/0033 ,  C09B23/083 ,  C09B23/086 ,  G01N21/6458 ,  G01N33/582 ,  G01N2333/988 ,  Y02A50/30

摘要： The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.

公开(公告)号：US20240327414A1

公开(公告)日：2024-10-03

申请号：US18582369

申请日：2024-02-20

申请人： Boehringer Ingelheim Vetmedica GmbH ,  NIHON NOHTAKU CO., LTD.

发明人： Bart Herlé ,  Hannes Fiepko KOOLMAN ,  Alan Long ,  Robin Meier ,  Ikki Yonemura

IPC分类号： C07D487/04 ,  A01N43/90 ,  A01P7/04 ,  A61K31/444 ,  A61K31/5025 ,  A61P33/14 ,  C07D471/04

CPC分类号： C07D487/04 ,  A01N43/90 ,  A01P7/04 ,  A61K31/444 ,  A61K31/5025 ,  A61P33/14 ,  C07D471/04

摘要： The present invention relates to N-oxide compounds of formula (I) or formula (Ia) or formula (Ib)




wherein the variables are as defined in the description and/or in the claims, which can be used as antiparasitic agents for the treatment, prevention and/or control of parasitic infections and/or infestations in/on animals as well as crop protection agents.

公开(公告)号：US20240316022A1

公开(公告)日：2024-09-26

申请号：US18573731

申请日：2022-06-30

申请人： TYRA BIOSCIENCES, INC.

发明人： Robert L. HUDKINS ,  Daniel C. BENSEN

IPC分类号： A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/5383 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D487/10 ,  C07D491/107 ,  C07D491/113 ,  C07D498/04

CPC分类号： A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/5383 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D487/10 ,  C07D491/107 ,  C07D491/113 ,  C07D498/04

摘要： Disclosed herein are compounds and methods of treating diseases and/or conditions associated with FGFR inhibition.

公开(公告)号：US20240309002A1

公开(公告)日：2024-09-19

申请号：US18665923

申请日：2024-05-16

申请人： Shionogi & Co., Ltd.

发明人： Kouhei NODU ,  Yusuke Tateno ,  Kengo Masuda ,  Yuji Nishiura ,  Yoshikazu Sasaki ,  Yu Hinata

IPC分类号： C07D471/20 ,  A61K31/438 ,  A61K31/444 ,  C07D471/10 ,  C07D487/10 ,  C07D491/20 ,  C07D519/00

CPC分类号： C07D471/20 ,  A61K31/438 ,  A61K31/444 ,  C07D471/10 ,  C07D487/10 ,  C07D491/20 ,  C07D519/00

摘要： The present invention provides the compound represented by the following formula (I):






wherein a moiety represented by formula:








or the like;

y is 0 or 1; R1 is hydrogen or the like; R2a and R2b are taken together with an adjacent carbon atom to form ring B; ring B is a substituted or unsubstituted non-aromatic carbocycle or the like; R3a is hydrogen or the like; R3b is hydrogen or the like; R4a is represented by formula:





L1 is a single bond or the like; L2 is —C(═O)— or the like; La is a single bond or the like; R7 is substituted or unsubstituted alkyl or the like; R4b is substituted or unsubstituted alkyl or the like; R4c is each independently halogen or the like.

公开(公告)号：US20240308998A1

公开(公告)日：2024-09-19

申请号：US18575006

申请日：2022-06-29

申请人： Tay Therapeutics Limited

发明人： Christopher Andrew WOODLAND ,  Mark BELL

IPC分类号： C07D471/04 ,  A61K31/444 ,  A61K31/506

CPC分类号： C07D471/04 ,  A61K31/444 ,  A61K31/506

摘要： This invention relates to compounds comprising a pyrrolopyridone core, pharmaceutically-acceptable salts thereof, and compositions comprising the same. The compounds and salts herein are useful as anti-inflammatory and/or other therapies.

公开(公告)号：US20240308978A1

公开(公告)日：2024-09-19

申请号：US18271192

申请日：2022-01-07

申请人： IFM Due, Inc.

发明人： Shankar Venkatraman ,  Jason Katz ,  William R. Roush ,  Hans Martin Seidel

IPC分类号： C07D401/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  C07D401/12 ,  C07D471/04

CPC分类号： C07D401/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  C07D401/12 ,  C07D471/04

摘要： This disclosure features chemical entities of Formula I (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.