公开(公告)号：US11168056B2

公开(公告)日：2021-11-09

申请号：US16876966

申请日：2020-05-18

Applicant: H. Lundbeck A/S

Inventor： Mikkel Fog Jacobsen ,  Martin Juhl ,  Frans Dennis Therkelsen ,  Kåre Søndergaard ,  Tobias Gylling Frihed

IPC: C07D215/06 ,  C07D317/60

Abstract: The present invention relates to a new process for manufacturing (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-g]quinoline with formula (Ib) below, (4aR,10aR)-1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol with formula (I) below and salts thereof. Both compounds are for use in the treatment of neurodegenerative diseases and disorders such as Parkinson's Disease. The invention also relates to new intermediate compounds of said process.

公开(公告)号：US20200369705A1

公开(公告)日：2020-11-26

申请号：US16876843

申请日：2020-05-18

Applicant: H. Lundbeck A/S

Inventor： Martin Juhl ,  Lisbet Kværnø ,  Mikkel Fog Jacobsen

IPC: C07H15/26

Abstract: The present invention relates to a process for manufacturing (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]guinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below and pharmaceutically acceptable salts thereof The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.The invention also relates to a new intermediate of said process.

公开(公告)号：US09975850B2

公开(公告)日：2018-05-22

申请号：US15480647

申请日：2017-04-06

Applicant: H. Lundbeck A/S

Inventor： Mikkel Fog Jacobsen ,  Florian Anton Martin Huber

IPC: C07D209/14 ,  B01D3/36

CPC classification number: C07D209/14 ,  B01D3/36 ,  C07D209/16

Abstract: The present invention relates to the preparation of N-(2-(6-fluoro-1H-indol-3-yl)-ethyl)-3-(2,2,3,3-tetrafluoropropoxy)-benzylamine (Compound I), INN-name idalopirdine, and pharmaceutically acceptable salts thereof:

公开(公告)号：US20150336867A1

公开(公告)日：2015-11-26

申请号：US14653318

申请日：2013-12-19

Applicant: H. LUNDBECK A/S

Inventor： Mikkel Fog Jacobsen ,  Sebastian Brandes

IPC: C07C49/697 ,  C07B59/00

CPC classification number: C07B59/001 ,  C07B2200/05 ,  C07C49/697 ,  C07D295/073

Abstract: The present invention discloses the compound 6-chloro-3-(phenyl-d5)-inden-1-one (I) and routes of synthesis to obtain (I). In a further aspect the present invention discloses the use of (I) for the synthesis of (S)-6-chloro-3-(phenyl-d5)-indan-1-one.

Abstract translation: 本发明公开了化合物6-氯-3-（苯基-d 5） - 茚-1-酮（I）和合成路线以获得（I）。 在另一方面，本发明公开了（I）用于合成（S）-6-氯-3-（苯基-d 5） - 茚满-1-酮的用途。