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![SOLID FORMS OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID](/abs-image/US/2024/06/13/US20240190909A1/abs.jpg.150x150.jpg)
公开(公告)号：US20240190909A1
公开(公告)日：2024-06-13
申请号：US18511231
申请日：2023-11-16
Applicant: H. Lundbeck A/S
Inventor： Klaus Gjervig Jensen , Lisbet Kværnø , Morten Jørgensen , Martin Juhl , Heidi Lopez De Diego , Karin Fredholt , Frans Dennis Therkelsen , Tobias Gylling Frihed , Mikkel Fog Jacobsen
IPC: C07H15/26
CPC classification number: C07H15/26 , C07B2200/13
Abstract: The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below.
The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.-
![Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid](/abs-image/US/2024/01/02/US11858954B2/abs.jpg.150x150.jpg)
公开(公告)号：US11858954B2
公开(公告)日：2024-01-02
申请号：US17392970
申请日：2021-08-03
Applicant: H. Lundbeck A/S
Inventor： Klaus Gjervig Jensen , Lisbet Kværnø , Morten Jørgensen , Martin Juhl , Heidi Lopez de Diego , Karin Fredholt , Frans Dennis Therkelsen , Tobias Gylling Frihed , Mikkel Fog Jacobsen
IPC: C07H15/26
CPC classification number: C07H15/26 , C07B2200/13
Abstract: The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below.
The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.-
![Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid](/abs-image/US/2021/09/07/US11111263B2/abs.jpg.150x150.jpg)
公开(公告)号：US11111263B2
公开(公告)日：2021-09-07
申请号：US16876878
申请日：2020-05-18
Applicant: H. Lundbeck A/S
Inventor： Martin Juhl , Frans Dennis Therkelsen , Tobias Gylling Frihed
Abstract: The present invention relates to a process for manufacturing (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below and salts thereof The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.
The invention also relates to new intermediates of said process.-
![PROCESS FOR THE MANUFACTURING OF (6AR,10AR)-7-PROPYL-6,6A,7,8,9,10,10A,11-OCTAHYDRO-[1,3]DIOXOLO[4',5':5,6]BENZO[1,2-G]QUINOLINE AND (4AR,10AR)-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDRO-BENZO[G]QUINOLINE-6,7-DIOL](/abs-image/US/2020/11/26/US20200369615A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200369615A1
公开(公告)日：2020-11-26
申请号：US16876966
申请日：2020-05-18
Applicant: H. Lundbeck A/S
Inventor： Mikkel Fog Jacobsen , Martin Juhl , Frans Dennis Therkelsen , Kåre Søndergaard , Tobias Gylling Frihed
IPC: C07D215/06 , C07D317/60
Abstract: The present invention relates to a new process for manufacturing (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-g]quinoline with formula (Ib) below, (4aR,10aR)-1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol with formula (I) below and salts thereof. Both compounds are for use in the treatment of neurodegenerative diseases and disorders such as Parkinson's Disease. The invention also relates to new intermediate compounds of said process.
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![PROCESS FOR THE MANUFACTURE OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID](/abs-image/US/2024/10/24/US20240352055A1/abs.jpg.150x150.jpg)
公开(公告)号：US20240352055A1
公开(公告)日：2024-10-24
申请号：US18507662
申请日：2023-11-13
Applicant: H. LUNDBECK A/S
Inventor： Martin Juhl , Frans Dennis Therkelsen , Tobias Gylling Frihed
Abstract: The present invention relates to a process for manufacturing (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below and salts thereof.
The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.
The invention also relates to new intermediates of said process.-
Patent Agency Ranking
![SOLID FORMS OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID](/abs-image/US/2022/01/27/US20220024962A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220024962A1
公开(公告)日：2022-01-27
申请号：US17392970
申请日：2021-08-03
Applicant: H. Lundbeck A/S
Inventor： Klaus Gjervig Jensen , Lisbet Kværnø , Morten Jørgensen , Martin Juhl , Heidi Lopez de Diego , Karin Fredholt , Frans Dennis Therkelsen , Tobias Gylling Frihed , Mikkel Fogh Jacobsen
IPC: C07H15/26
Abstract: The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below. The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.
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![Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid](/abs-image/US/2021/09/28/US11130775B2/abs.jpg.150x150.jpg)
公开(公告)号：US11130775B2
公开(公告)日：2021-09-28
申请号：US16876908
申请日：2020-05-18
Applicant: H. Lundbeck A/S
Inventor： Klaus Gjervig Jensen , Lisbet Kværnø , Morten Jørgensen , Martin Juhl , Heidi Lopez de Diego , Karin Fredholt , Frans Dennis Therkelsen , Tobias Gylling Frihed , Mikkel Fog Jacobsen
IPC: C07H15/26
Abstract: The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below. The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.
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![PROCESS FOR THE MANUFACTURING OF (6AR,10AR)-7-PROPYL-6,6A,7,8,9,10,10A,11-OCTAHYDRO-[1,3]DIOXOLO[4',5':5,6]BENZO[1,2-G]QUINOLINE AND (4AR,10AR)-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDRO-BENZO[G]QUINOLINE-6,7-DIOL](/abs-image/US/2024/01/18/US20240018107A1/abs.jpg.150x150.jpg)
公开(公告)号：US20240018107A1
公开(公告)日：2024-01-18
申请号：US18359136
申请日：2023-07-26
Applicant: H. Lundbeck A/S
Inventor： Mikkel Fog Jacobsen , Martin Juhl , Frans Dennis Therkelsen , Kåre Søndergaard , Tobias Gylling Frihed
IPC: C07D215/06 , C07D317/60
CPC classification number: C07D215/06 , C07D317/60
Abstract: The present invention relates to a new process for manufacturing (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-g]quinoline with formula (Ib) below, (4aR,10aR)-1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol with formula (I) below and salts thereof.
Both compounds are for use in the treatment of neurodegenerative diseases and disorders such as Parkinson's Disease. The invention also relates to new intermediate compounds of said process.-
![Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid](/abs-image/US/2023/12/26/US11851456B2/abs.jpg.150x150.jpg)
公开(公告)号：US11851456B2
公开(公告)日：2023-12-26
申请号：US17391439
申请日：2021-08-02
Applicant: H. Lundbeck A/S
Inventor： Martin Juhl , Frans Dennis Therkelsen , Tobias Gylling Frihed
Abstract: The present invention relates to a process for manufacturing (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below and salts thereof
The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.
The invention also relates to new intermediates of said process.-
![PROCESS FOR THE MANUFACTURE OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID](/abs-image/US/2022/06/23/US20220194978A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220194978A1
公开(公告)日：2022-06-23
申请号：US17391439
申请日：2021-08-02
Applicant: H. Lundbeck A/S
Inventor： Martin Juhl , Frans Dennis Therkelsen , Tobias Gylling Frihed
Abstract: The present invention relates to a process for manufacturing (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below and salts thereof The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.
The invention also relates to new intermediates of said process.
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