公开(公告)号：US20210107921A1

公开(公告)日：2021-04-15

申请号：US17026619

申请日：2020-09-21

Applicant: Hoffmann-La Roche Inc.

Inventor： Joerg BENZ ,  Luca GOBBI ,  Uwe GRETHER ,  Steven Paul HANLON ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Martin KURATLI ,  Guofu LIU ,  Fionn O`HARA ,  Hans RICHTER ,  Martin RITTER

IPC: C07D498/04

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, Q, U, V, W, X, Z, m, n, and R1 to R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20210094972A1

公开(公告)日：2021-04-01

申请号：US17027952

申请日：2020-09-22

Applicant: Hoffmann-La Roche Inc.

Inventor： Joerg BENZ ,  Luca GOBBI ,  Uwe GRETHER ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Rainer E. MARTIN ,  Fionn O`HARA ,  Bernd PUELLMANN ,  Hans RICHTER ,  Martin RITTER

IPC: C07D498/04 ,  A61K9/20 ,  A61K9/48

Abstract: The invention provides new heterocyclic compounds having the general formulae (Ia) and (Ib) wherein A, B, and L are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20210094971A1

公开(公告)日：2021-04-01

申请号：US17012589

申请日：2020-09-04

Applicant: Hoffmann-La Roche Inc.

Inventor： Uwe GRETHER ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Marius Daniel Rinaldo LUTZ ,  Fionn O`HARA ,  Hans RICHTER

IPC: C07D498/04

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L, X, R1, R2, R3 and R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20210094943A1

公开(公告)日：2021-04-01

申请号：US17017200

申请日：2020-09-10

Applicant: Hoffmann-La Roche Inc.

Inventor： Joerg BENZ ,  Luca GOBBI ,  Uwe GRETHER ,  Katrin GROEBKE ZBINDEN ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Rainer E. MARTIN ,  Fionn O`HARA ,  Bernd PUELLMANN ,  Hans RICHTER ,  Martin RITTER

IPC: C07D413/12 ,  A61K9/20 ,  A61K9/48 ,  C07D265/28

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L1, X, m, n, and RI to R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20200040032A1

公开(公告)日：2020-02-06

申请号：US16596243

申请日：2019-10-08

Applicant: Hoffmann-La Roche Inc.

Inventor： Konrad BLEICHER ,  Jérôme HERT ,  Carsten KROLL ,  Fabian DEY

IPC: C07K5/09 ,  A61P31/04

Abstract: The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R8′, R9, R9′, X1, X2, X3, X4, X5, X6, X7, X8, X9 and X10 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by Acinetobacter baurnannii.